Sentences with phrase «cell surface receptors such»

Microbes that cause diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways — cell surface receptors such as CTLA4 and PD - 1 — to slow immune cells and prevent their elimination by the host.

Not exact matches

The human body has about 1,000 kinds of such receptors, structures on the surface of cells, which let the body respond to a wide variety of chemical signals, like adrenaline.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

In normal cell function messenger chemicals, such as various growth factors and insulin, bind to protein receptors on the cell's surface.

A normal cell has chemical receptors on its surface that link up with specific molecules generated by the body and control the timing of such functions as eating and sleeping.

Antigen - presenting cells (APCs), such as dendritic cells and macrophages, activate T cells by engaging protein receptors on the T cell surface.

PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.

For example, Dr. Shiloh said, preventing Mtb from attaching to receptors on the M - cell surface — such as by vaccinating against a bacterial protein — could block the bacteria's entry, infection, and spread to other organs.

Adenosine helps to sustain such cells by fitting into a protein called the A2A adenosine receptor on their surfaces, like a key into a lock.

Receptors are proteins that are usually located on the external surface of the cell membrane; they provide specific recognition sites for messenger substances such as hormones, neurotransmitters and growth factors.

In a major innovation reported last year, Lerner, Zhang and their colleagues developed a basic method for selecting antibodies that not only bind to a given target, such as a cell - surface receptor, but also have a desired biological function — such as activating the receptor on mammalian cells.

This work outlines how a receptor termed LFA - 1 on the surface of T - cells mediates adhesion to other cells such as cancer cells.

We delve into very fundamental problems such as «how does a malaria red blood cell attach itself to a blood vessel» or «how does binding of a ligand to a cell surface receptor or contact of a crystalline surface with the plasma membrane drive lipid sorting and how will this lead to signalling» but then immediately apply it to a practical problem such as «how does contact of uric acid crystals with dendritic cells cause gout in affected joints and how can we prevent this occurrence?»

The pathways that connect expression of stem cell surface glycoconjugates such as the TRA -1-60 / GCTM - 2 antigen, receptors, and growth factors in human and even mouse ES cells with the transcriptional networks that regulate pluripotency remain unclear.