Sentences with phrase «cell survival»
"Cell survival" refers to the ability of cells to stay alive and function properly. It means that the cells are able to withstand various stressors, such as diseases, injuries, or changes in their environment, and continue to carry out their necessary tasks to maintain the overall health and functioning of the organism. Full definition
Yet fats are essential for cell survival as they form the basic structure for the biological membranes which separate cells from the environment and form functional units inside them.
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It can promote cancer cell survival and growth of ER + breast cancer cells.
The top and bottom photos show the difference in stem cell survival, merely by altering the medium used for growth.
The mechanism for this markedly enhanced effect appears to be increased cell survival and retention.
These physical effects lead to cell signaling pathways for enhanced cell survival.
The technique for the first time blends two existing cell - handling methods to improve cell survival rates and increase the efficiency of inserting DNA into cells.
Cell survival rates ranged from 70 % to 90 %.
This allows researchers to randomly screen the entire genome for genes that affect cell survival.
These interactions not only enable cell survival, but also influence fundamental cellular properties and behaviors.
But turning down the «thermostat» in a sense, may give the cancer cell a survival edge.
Such diets provide a broad approach to cancer prevention because they contain many different compounds that can attack the multiple pathways of cancer stem cell survival.
They kill the cells by simultaneously eliminating the genes required for cell survival.
Results from earlier reports and this study support the hypothesis that the PI3K - AKT - mTOR pathway contributes to tumor cell survival in ALCL as shown in this proposed model.
These findings suggest that activation of mTOR signaling contributes to tumor cell survival in ALK + ALCL, thus providing a potential therapeutic target in this lymphoma type.
Rather, the group speculates that the transplanted cells secreted protective neurotrophins, proteins that promote cell survival by keeping neurons from inducing apoptosis (programmed cell death).
On a different note, coconut oil mitigates amyloid beta toxicity in cortical neurons by up - regulating signaling of cell survival pathways (Nafar, Clarke, & Mearow, 2017).
Bcl - 2 proteins play a key role in cell survival by protecting against a form of cell suicide known as apoptosis.
GLP - 1 receptors are also found in the brain, and prior research has shown that activating them can boost the function of dopamine connections, act as an anti-inflammatory, improve energy production, and switch on cell survival signals.
Retinoid - X-receptors (a / ß) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.
STAT5 belongs to a family of transcription factors that regulate cytokine - induced gene expression and is constitutively activated in several human cancers including breast cancer, where it promotes the expression of genes encoding cell survival factors (44).
«Speedy restoration of blood flow to the brain is crucial for brain cell survival everywhere.»
«Previous studies stated that LKB1 was a tumour suppressor in ovarian cancer, meaning that tumour cells need to get rid of LKB1 to cause cancer,» says Dr. Shepherd «but our work is in direct conflict with these studies, because we definitively show that ovarian cancer cells still have LKB1 and that this molecule allows ovarian cancer spheroids to change their metabolism, promote tumour cell survival and make them more resistant to chemotherapy.»
Zinc finger nuclease mediated knockout of ADP - dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.
They showed that NDP1 bioactivity governs key gene interactions decisive in cell survival when threatened by disease or injury.
(2007) Effects of TRPV1 Overexpression and Silencing on Retinal Ganglion Cell Survival in vitro (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 4358).
Autophagic targeting of SRC promotes cancer cell survival upon reduced FAK signalling.
It was also discovered that it maintains specific cell signalling pathways necessary for nerve cell survival.
Goerlitz is part of a Georgetown research team that traveled to McMurdo Station, a research center in Antarctica operated by the National Science Foundation, to test theories of long - term cell survival in microbes using next - generation DNA sequencing.
The same pathways for beta cell survival and DNA damage repair were also found to be altered in diabetic patient samples, indicating that a genetic predisposition for fragile beta cells may underlie who develops diabetes.
«Structure of a protein complex related with cell survival revealed.»
The team found that Isl1 expression protected hair cells from degeneration in aging and promoted hair cell survival after exposure to loud noise.
The researchers found that Takinib inhibits an enzyme called TAK - 1, which serves as a switch controlling cell survival in the TNF - alpha signaling process.
This new study now shows that BCL - 2 «teams up» with MCL - 1 and both these proteins crucially determine NK cell survival in our body, and the majority of NK cells died following a reduction in the levels of BCL - 2.
In about 20 % of the cases tested, however, the Whitehead team discovered that these new phenotypes afford the yeast cell a survival advantage.
GSK3 function is essential for B cell survival in germinal centers.
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science.
Overall the current study showed that even without activating mutations in Ras or Braf genes, ERK1 / 2 and AKT play a critical role in B16F10 cell survival upon radiation exposure and possibly act through common downstream effector / s.
mTOR - rictor complex (composed of mTOR, rictor, and GβL) is not rapamycin sensitive and modulates cell survival and proliferation by direct phosphorylation of AKT on Ser473 and by facilitating AKT phosphorylation on Thr308 by PDK1 in vitro (13).
As these factors can exert protective effects on retinal neurons [52]--[56] and neurons in other neurodegenerative disease models [49], [57], [58], it seems likely that these substances may contribute to the latent photoreceptor cell survival we observe in the dystrophic retina.
Our objective is to determine whether this mutation is involved in AMD by (1) understanding the functional consequences of this genomic variation on expression of COL8A1 and / or its neighbor genes, and (2) investigating photoreceptors and RPE cell survival, retinal and choroidal angiogenesis, structure integrity of the choroid / Bruch's membrane, and the quality of the vision, in organisms with the COL8A1 mutation.
Acute Psychosocial Stress Reduces Cell Survival in Adult Hippocampal Neurogenesis without Altering Proliferation.
When introduced into the MDA - MB - 231 cells, the Δ2A mutant did not induce apoptosis of these cells whereas WT LARP7 readily impaired cell survival, supporting the model that the ability of LARP7 to assemble 7SK snRNP and suppress P - TEFb is necessary for its tumor suppressor potential.
Review mechanisms by which tumor cells resist inhibitors that target cell survival and growth pathways
This balance is coordinated by some proteins that promote cell death and others that support cell survival.
H2 supports the body's in - house antioxidant system through selective activation of specific cell - signaling pathways that are thought to contribute to the regulation of a «wide variety of antioxidant, detoxification, and cell survival genes.»