Sentences with phrase «cell survival signals»

GLP - 1 receptors are also found in the brain, and prior research has shown that activating them can boost the function of dopamine connections, act as an anti-inflammatory, improve energy production, and switch on cell survival signals.

«NF - kB is a major cell survival signaling molecule, but it needs to be induced,» said Verma.

Studies have shown that exposure of tumor cells to therapeutic doses of radiation activates cell survival signaling pathways such as EGFR - RAS [2 - 5] and its downstream molecules such as ERK1 / 2, PI3K - AKT, JNK, etc. apart from several other signaling molecules [4, 6, 7].

Not exact matches

A Canadian study published this year around the same time titled «Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways» observed that coconut oil and its medium chain fatty acids (MCFAs) protect against amyloid beta (Aβ) induced neurotoxicity in primary rat cortical neurons.

This could signal to cells that food is scarce, triggering processes that promote survival.

The researchers then found that, while the drug continued to inhibit FGFR activity in the resistant cells, its inhibition of FGFR signaling had no appreciable effect on the cells» survival.

Several target molecules have also been identified in intracellular signalling pathways and in cell survival proteins.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

Consistent with previous findings, Apc suppression in the animals activated the Wnt signaling pathway, which is known to control cell proliferation, migration, and survival.

«Elevated calcium triggers multiple signaling pathways that promote cell doubling, survival and changes in the cell that promote cancer invasion and metastasis,» says Dr. Copland.

The researchers found that Takinib inhibits an enzyme called TAK - 1, which serves as a switch controlling cell survival in the TNF - alpha signaling process.

Oligodendrocytes, the cells that are known to produce the myelin sheaths which enable saltatory conduction of action potentials along the myelinated axons, are modulators of signal transmission along neuronal connections (axons) and also promote neuronal survival by providing metabolic support.

His lab studies a particular signaling pathway, the RAS / RAF / MEK / ERK pathway, which regulates cell growth and survival in several cancers.

In particular, his laboratory focuses on the regulation of key signaling networks that regulate cancer cell growth and survival.

Using tumor cells from DLBCL patients, the scientists discovered that the inactivation of BTK in resistant tumors triggers the over-activation of alternative signals that promote tumor cell survival and proliferation.

These signals are passed within the cell from one protein to another and ensure cell growth and survival.

By identifying the molecular signals emitted through the soil by friendly fungi, the protein enables a plant to «roll out the red carpet» for cell colonisation by the fungi, and all the survival advantages this mutually - beneficial relationship brings — the fungi feeds minerals such as phosphate into plant cells in return for sugar extraction.

These physical effects lead to cell signaling pathways for enhanced cell survival.

Recent studies with human breast cancer cell lines have also shown that Shp2 mediates survival signals in cancer cells.

Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances.

Use of exon - based transcriptome profiling to identify novel signaling pathways and survival - associated genes in diffuse large B - cell lymphoma.

Thirdly, the current, almost universal dependency of organoid culture on the use of Matrigel as a replacement for the function of the extracellular basement matrix in providing structural support and survival signals to the epithelial cells hampers clinical application, considering its origin from a mouse sarcoma cell line, its poorly defined composition and its mechanical rigidity after plating.

Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum - free medium.

GPCRs and their downstream signaling are involved in cancer growth and development by controlling many features of tumorigenesis, including immune cell - mediated functions, proliferation, invasion and survival at the secondary site.

Autophagic targeting of SRC promotes cancer cell survival upon reduced FAK signalling.

Unconventional ligand activation of herpesvirus entry mediator signals cell survival.

We are identifying and characterizing the signaling molecules that control the interphase between cell survival and death cascades.

14 -3-3 proteins are essential signalling hubs for beta cell survival.

The FLT3 - signaling pathway controls cell proliferation and survival, particularly of hematopoietic progenitor cells.

We have recently shown that signaling by BMP, once thought to maintain cell survival, helps to control epithelial cell shape and organization in the developing Drosophila wing.

Data from the laboratory shows that signals from these molecules through their receptors control the activities and long - term survival of T cells, as well as affecting the activities of other cell types including dendritic cells, macrophages, and epithelial cells.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

These findings suggest that activation of mTOR signaling contributes to tumor cell survival in ALK + ALCL, thus providing a potential therapeutic target in this lymphoma type.

Activation of Mammalian Target of Rapamycin Signaling Pathway Contributes to Tumor Cell Survival in Anaplastic Lymphoma Kinase — Positive Anaplastic Large Cell Lymphoma

The role of these molecules in driving disease pathology might vary, with described activities of HVEM signaling promoting T cell expansion or survival, analogous to certain activities of OX40 and 4 - 1BB, and other activities of HVEM or LTβR increasing the function of diverse cells such as stromal cells, dendritic cells, macrophages, eosinophils, epithelial cells and keratinocytes.

Our present studies are focusing on the molecular interactions which prevent excessive T cell death after the initial period of clonal expansion and which are essential for promoting late T cell division and providing long - term survival signals.

In 2002, his group was the first to report the design of «second - generation» CARs that, in addition to a binding domain outside of the T cell and a signaling domain inside, included a costimulatory domain designed to promote cell proliferation and survival.

In tumour cells, the signals controlling cell growth and survival are dysfunctional, thus enabling the cells to grow in an uncontrolled manner.

They also found that cap cells produce a survival signal, Wnt6.

Sphingosine -1-phosphate is a potent signaling lipid involved in numerous biological functions including, cellular proliferation, survival, migration, invasion, differentiation, architecture, immune cell trafficking, angiogenesis and vascular integrity.

In leukemic cells, like in other cancers, STAT proteins are frequently constitutively activated in the absence of cytokine stimulation, providing malignant cells with persistent signals and self - sufficiency for survival and proliferation.1

As a result, signals that promote cancer cell proliferation and survival are produced continuously.

For liver transplant - free survival, we identified a genome - wide significant signal and demonstrated expression of the candidate gene RSPO3 in key liver - resident effector cells.

Treatment with a single RTK inhibitor had little effect in these tumors, but combined therapy to target several RTKs (with Iressa / Tarceva / Gleevec, etc.) decreased signaling, cell survival, and anchorage - independent growth in GBM.

H2 supports the body's in - house antioxidant system through selective activation of specific cell - signaling pathways that are thought to contribute to the regulation of a «wide variety of antioxidant, detoxification, and cell survival genes.»

It was also discovered that it maintains specific cell signalling pathways necessary for nerve cell survival.

As with stroke, CNB - 001 was again discovered to maintain the critical signalling pathways needed for nerve cell survival, and also the connections between nerve cells which are lost with the injury.

Pterostilbene limits the expression of the mTOR signaling pathway, which helps to regulate the growth, survival and proliferation of cells.

On a different note, coconut oil mitigates amyloid beta toxicity in cortical neurons by up - regulating signaling of cell survival pathways (Nafar, Clarke, & Mearow, 2017).

Building off of the data in hOSA, Dr. Baldanza's study will address the hypothesis that HH signaling is also active in cOSA, and targeted inhibition of the pathway will negatively impact and slow OSA cell growth and survival.