Sentences with phrase «cell targeting with»

Not exact matches

The start - up's premiere product, the Thin Ice vest, uses cold therapy to target areas of the body with high concentrations of thermoreceptors, which are nerve cells that are able to detect the presence of hot or cold temperatures.

Instead of being injected into the bloodstream and exposed to the rest of the body's tissue — with all the unpleasant side effects, as is the case with chemotherapy — these agents only target cancer cells.

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

Unlike some of the promising treatments that have failed in 2017 that deal with the so - called «amyloid hypothesis» (the treatments target amyloid beta deposits in the brain that accumulate in people with Alzheimer's disease), approaches that try to prevent nerve cells from dying wouldn't have any impact on that buildup.

Biotech giant Gilead Sciences is beefing up its cancer drug portfolio with a $ 11.9 billion deal to buy Kite Pharma, a company focused on a groundbreaking new class of treatments that turns the body's own immune cells into targeted blood cancer killers.

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

Cell phone companies know it, too, as they target the preteen market with phones that appeal directly to children.

It is packed with live immune cells that actively target and kill bacteria, so it takes longer to spoil than pasteurized cow's milk or formula.

And it CAN be a good for political organizing, if your targets are in populations with high cell - phone and / or Twitter usage (for instance, younger — and plugged - in — urban black and latino voters).

Unlike conventional chemotherapies and radiation that indiscriminately eradicate fast - growing tissues and ravage people's bodies with side effects, new therapies specifically target tumors using tailored cells from individual patients.

The other two major targets in the field, circulating tumor cells and exosomes, come with their own challenges.

Still, «for something that really tends to interfere with your everyday life, I would think that a treatment that targets just these cells could be appropriate,» she said.

Similarly, it may be possible to identify and validate new targets for drugs that would selectively kill tumor cells with a particular molecular context.

«We've been targeting human cells with therapeutics that modulate the way the cell makes lipids, and we like to target the human cell because it isn't likely to mutate and become resistant to the drug.

The exterior of the nanoparticle is coated with nucleic acids that act as targeting agents, drawing the delivery system to the retina and facilitating uptake by RPE cells.

By delivering this version of Cas9 along with the guide RNA strand into single cells, the researchers can target one genetic sequence per cell.

There, some of the added DNA was swapped with the matching target sequences in the cells» genomes.

Our work suggests that targeting a specific stem cell phenotype, for example with immunotherapies, could be beneficial in patients with oligodendroglioma.»

In a paper published in the current online issue of the journal Small, titled «Immune Cell - Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting,» the researchers report the use of a novel biodegradable and photoluminescent poly (lactic acid) nanoparticle, loaded with melanoma - specific drugs with immune cells as the nanoparticle carriers.

The researchers also affected mouse models with Mantle Cell Lymphoma, using the new platform to target cancer cells, induce cell death and dramatically improve overall surviCell Lymphoma, using the new platform to target cancer cells, induce cell death and dramatically improve overall survicell death and dramatically improve overall survival.

By combining this strategy with cancer cell - targeting materials, we should be able to develop a therapy for glioblastoma and other challenging cancers in the future.»

By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital (BWH) were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models.

By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers were able to target cancer cells during a transitional stage when they were most vulnerable.

The finding that norovirus targets tuft cells fits with previous research on the virus and other pathogens.

The tumor - cell survival factors uncovered by this study might one day be targeted with drugs to further diminish people's risk of metastasis.

Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to Penn State College of Medicine researchers.

Dr Michael P. Lisanti, Professor of Translational Medicine at the University of Salford, said: «We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey - bee derivative, but by far the most exciting are the results with Vitamin C.

To test this, the researchers treated the cells with a variety of targeted therapeutics immediately after chemotherapy.

«It's blue sky, but we can certainly envision making different inhibitors of channels with monobodies, which could perhaps be targeted against harmful cells and microorganisms.»

«Considering that PDPN is associated with poor prognosis in GBM, CAR T - cell therapy that targets this protein is promising for treatment of patients with relapsed or resistant tumors following first - line chemotherapy,» says Toshihiko Wakabayashi, a coauthor and the chair of Department of Neurosurgery Nagoya University School of Medicine.

More importantly, it opens up exciting avenues of research to explore how restoration of p53 with drugs such as those that target ERAP1 can help to harness the immune system to recognise and destroy cancer cells.»

With the dilemma percolating in the back of his mind, tenOever had a eureka moment while shopping with his wife along Lexington Avenue in Manhattan: «Every cell has a pool of microRNAs, even if they didn't target the viruses,» he explaWith the dilemma percolating in the back of his mind, tenOever had a eureka moment while shopping with his wife along Lexington Avenue in Manhattan: «Every cell has a pool of microRNAs, even if they didn't target the viruses,» he explawith his wife along Lexington Avenue in Manhattan: «Every cell has a pool of microRNAs, even if they didn't target the viruses,» he explains.

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

The protein has long been considered too complex to target with a drug as it also is crucial to proper function of many immune system cells, not just B cells gone bad.

In one experiment with human cells, a guide RNA should have led the Cas9 enzyme only to a gene on chromosome 2 (yellow bar), but it also directed the enzyme to many off - target sites (red) on several other chromosomes.

Rahul Palchaudhuri, a postdoctoral fellow in Scadden's lab and first author on the paper, armed CD45 - targeting antibodies with a payload that destroys only existing blood cells.

Other researchers have already loaded hollow origami structures with drugs to target specific types of cancer cells, created DNA «robots» that walk across surfaces, and mimicked the shape of viruses.

These relatively normal tissue cells communicate with the cancer cells and play a major role in cancer progression, and could offer a new target for treatment.

Around 15 per cent of women with breast cancer have this form of the disease, in which tumour cells lack the three receptors that most drugs target.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.

Although some cancers — particularly those that are rife with mutations like lung cancer or melanoma — create more tangible targets on the surface of cells for the immune system to recognize and attack, other malignancies such as prostate and pancreatic cancers have proved more intransigent.

«The challenge is finding targets that exist on other types of cancer cells but not on normal cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who worked with Porter on testing the treatment in mice.

Johnson's team borrowed a technique from cancer biology, called the systematic evolution of ligands by exponential enrichment (SELEX), which creates a huge library of random, short chains of nucleotides, called aptamers, and then incubates them with a target of choice, such a specific breast cancer cell.

Though scientists have managed to come up with drugs that target and turn off aberrant BRAF signaling, cancer cells are clever.

Treatment for advanced melanoma has seen success with targeted therapies — drugs that interfere with division and growth of cancer cells by targeting key molecules — especially when multiple drugs are used in combination.

Joseph Wu of Stanford University, California, and his team have found that a mouse's immune system can be primed to recognise and target cancer cells by vaccinating them beforehand with stem cells.

In one, researchers working with mice at the Institute of Molecular and Cellular Biology in Singapore used antibodies to target proteins inside cancer cells — an impressive feat, since the antibodies were long considered too large to cross the cancer cell's outer membrane.

«There's a large amount of validation to ensure specificity of the antibodies and to make sure that the antibody is actually recognizing the intended target,» says Craig M. Thompson, director of production and molecular assays, with Cell Signaling Technology (CST), located in Danvers, Massachusetts.

«Although some non-small cell lung cancer patients have increased benefit of targeted therapy or immunotherapy instead of chemotherapy, for some groups of patients with NSNSCLC, chemotherapy has been the standard treatment for more than 30 years,» Gandhi notes.