Sentences with phrase «cell therapies remain»

Regenerative medicine and stem cell therapies remain highly unregulated throughout the world.

In short, stem cell therapies remain uncertain and risky, hampered by unforeseen complexities.

Not exact matches

While Nagy can get piggyBac to jump back out of his iPS cells, regulatory authorities considering the safety of experimental therapies are likely to remain nervous about cells that have been genetically manipulated.

The findings inject hard facts into a debate that has long divided the medical community, with many radiation oncologists preferring adjuvant therapy — radiation given soon after prostate removal to kill off any remaining cancer cells — and many urologists preferring salvage therapy — radiation given later, when prostate - specific antigen tests suggest it's needed.

In the GD2 CAR - T treated animals, the residual cancer cells did not express GD2, suggesting that these remaining cells were not vulnerable to the immune therapy and might be able to cause the cancer to recur.

While the combination of targeted therapies improves patient outcomes, any remaining cancer cells can lead to drug resistance.

In the current study, Dr. Xu and colleagues gave radiation therapy to a mouse model of human pancreatic cancer to eradicate the bulk tumors, while only the cancer stem cells remained in the residual scars.

The development of targeted therapies has significantly improved the survival of melanoma patients over the last decade; however, patients often relapse because many therapies do not kill all of the tumor cells, and the remaining cells adapt to treatment and become resistant.

The authors of the commentary emphasize that cell therapies must be approved by international and national regulatory agencies and remain under the strict vigilance of health authorities.

Researchers have used radioimmunotherapy (RIT) to destroy remaining human immunodeficiency virus (HIV)- infected cells in the blood samples of patients treated with antiretroviral therapy, offering the promise of a strategy for curing HIV infection.

But many stem cell scientists in Italy and abroad say it's too early for such a study because there is little to suggest that the therapy, whose details remain unpublished, might work.

The authors conclude that mesenchymal stem cell therapy has great potential as a therapeutic option in feline disease, but that many questions about the logistics of its use remain to be answered.

«Dormant disseminated tumors can be ticking time bombs, but now that we know some of the triggers, it may be possible to develop therapies to ensure that disseminated cancer cells remain in a dormant state, or other therapies that eradicate these cells before they form full - blown metastases.»

Stem cell therapies are clinically unproven, the physiology of head trauma remains a mystery, and rest is still the best Rx for pulled muscles.

Technology such as this, scientists said, may have a promising future in the identification and surgical removal of malignant tumors, as well as using near - infrared light therapies that can kill remaining cancer cells, both by mild heating of them and generating reactive oxygen species that can also kill them.

However, despite its marked promise for disease modeling, development of novel therapies, and regenerative medicine, stem cell derived organoid technology faces many remaining challenges.

Proton therapy is an advanced form of radiation treatment that is especially effective for reaching tumors or remaining cancer cells close to key organs such as the brain stem or spinal cord.

Adeno - associated viruses (AAVs) also remain episomal, have the ability to infect non-dividing cells, and (because of their low immunogenicity) are attractive tools for gene therapy.

Scope: 22 institutions Treatment: CD19 - targeting CAR T - cell therapy Results: 42 % of patients with aggressive large B - cell lymphoma remained in remission after 15 months

Studying the molecular mechanisms that enable the metastatic cells to remain in dormancy for so long and then wake up and generate these macrometastases will allow us to develop therapies to prevent relapse, or, if metastasis occurs, to make it chronic or even stop it from spreading.

The ability of cells to remain unaffected by HIV, in the absence of CCR5, has already been shown clinically, but this strategy has not been joined with gene therapy in making killer cells.

While the exact contribution adult - born neurons make to overall learning and memory remains mysterious, Song notes that these results are promising for any future nerve stem cell therapy.

However, they remain supportive of basic CRISPR research on animals and non-embryonic human cells to see if human germline gene therapy might be helpful in the future to fix genetic mutations.

DENVER — Despite very encouraging progress in the development and use of immunotherapy for patients with non-small cell lung cancer, much confusion remains regarding patient selection for each therapy.

Researchers at Harvard - affiliated McLean Hospital have found that fetal dopamine cells transplanted into the brains of patients with Parkinson's disease were able to remain healthy and functional for up to 14 years, a finding that could lead to new and better therapies for the illness.

The patch allows for the same type of therapy — using pancreatic cells to regulate insulin — but the pancreatic cells remain outside the body in the smart patch.

«JDRF remains dedicated to accelerating the delivery of beta cell replacement therapies to the T1D community, and we commend ViaCyte in its announcement of the first patients to be implanted with the PEC - Direct islet cell replacement therapy,» said Derek Rapp, JDRF President and Chief Executive Officer.

But gene therapy also needs to be carefully done and, ideally, two independent gene - manipulation systems would be used to ensure that stem cells remain firmly in control of clinicians.

Radiation therapy may be used to reduce the size of a cancer before surgery, to destroy any remaining cancer cells after surgery, or, in some cases, may be the main treatment.

Direct conversion or reprogramming of human postnatal cells into endothelial cells (ECs), bypassing stem or progenitor cell status, is crucial for regenerative medicine, cell therapy, and pathophysiological investigation but has remained largely unexplored.

Acute myeloid leukemia (AML) is the leading cause of leukemia mortality in the United States.1 Curative treatment involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or allogeneic stem cell transplantation based on the patient's risk for relapse.2 This approach has been employed for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability of many patients to tolerate the intense chemotherapy - based treatments, in particular hematological toxicity, further contributes to the poor outcomes noted in this disease.

Although surgery is usually successful, some people may also need medications that lower cortisol or radiation therapy to destroy remaining tumor cells.