Sentences with phrase «cell therapies such»

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

Not exact matches

New technologies such as gene and cell therapies hold out the potential to transform medicine and create an inflection point in our ability to treat and even cure many intractable illnesses.

With major clinical successes in areas such as CAR - T, gene therapy, immune - oncology, cell therapy and gene editing, many see 2017 as the year that biotech really came of age.

If ESCR using «excess» embryos from IVE» continues, the next step will likely be the pursuit of such «therapeutic» cloning — the creation of embryos through somatic cell nuclear transfer (SCNT) to provide individually tailored stem cell therapies.

During the sessions, U.S. and Cuban scientists explored such topics as the molecular mechanisms cancer cells employ to evade the body's immune system, new tools to image and manipulate that system, and ways to rethink how such therapies can best be deployed to reach patients where they receive health services.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

The act of reprogramming cells to make them as capable as ones from embryos apparently can result in aberrant cells that age and die abnormally, suggesting there is a long way to go to prove such cells are really like embryonic stem cells and can find use in therapies.

Researchers such as geneticist Richard King of the University of Minnesota and cell biologist Vitali Alexeev of Thomas Jefferson University are working on gene therapies or drugs that would fix albinism - causing mutations.

New products and developments, such as new drugs for cancer, fresh therapies for rare diseases, progress in medications for HIV / AIDS, and advances in stem cell research had the greatest positive impact.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

Eye diseases — such as age - related macular degeneration, as well as a genetic condition called Stargardt's macular dystrophy that afflicts young people — are considered excellent candidates for stem cell therapy because the eye is an immune - privileged site, meaning transplanted cells are not as likely to be rejected as foreign compared with transplants elsewhere.

These include the ability to bring new, innovative products to the market; progress in oncology, such as the approval of Genentech's drug Avastin for breast cancer and advances in the use of gene therapy, despite some setbacks; continuing progress in research on stem cells; the emergence of treatments for previously untreated diseases; and solutions for food and fuel shortages, such as biocrops and biofuels.

Being able to acquire new technologies, as well as becoming more innovative internally by venturing into new research areas, such as stem cell and gene therapy research, have allowed Genzyme to maintain its edge.

Two months after therapy, tissue analysis showed less scarring and higher levels of regenerative agents such as fibroblast growth factor — which accelerate healing — in rats treated with SIS plus stem cells compared with those treated with SIS alone.

Still, a few stem cell therapies have now been approved, such as a treatment available in India that takes stem cells from the patient's eye in order to regrow the surface of their cornea, and a US product based on other people's bone stem cells.

Clinical trials that charge enrollees to participate are ostensibly aimed at giving patients early access to promising therapies — often in the fields of stem cells or aging reversal — that are too unusual or have too little profit potential to get funding from traditional sources such as companies, foundations, or the National Institutes of Health.

Developing safe and effective therapies for conditions such as peripheral nerve disorders requires the ability to take investigations from cells in a petri dish to patients in a clinic.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

«The treatment of multiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical School.

Lanza says eye disease is a good place to start with such cell therapies because the eye doesn't reject foreign tissues, so no imunnosuppressive drugs are necessary.

Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

But many stem cell scientists in Italy and abroad say it's too early for such a study because there is little to suggest that the therapy, whose details remain unpublished, might work.

«Perhaps we can also combine resident memory T cells with other therapies such as checkpoint modulators (PD1 blockade) that would ensure a more hospitable environment for the reinfused cells.»

This makes adipose tissue, in theory, a readily available reservoir for regenerative therapies such as bone healing if doctors can get enough of those cells and compel them to produce bone.

Broad claims of success have sparked the ire of scientists, who insist the complexities of stem cell therapies make such success unlikely.

He envisions some sort of visual aid «designed to maximize the activity of these cells but notes that even if such therapies are possible, they won't be available anytime soon.

Many groups, including Urnov's company, are already using gene - editing tools to develop therapies that correct genetic defects in people (such as by editing white blood cells).

Experimental approaches such as gene therapy are also being investigated, but Dr. Rudnicki's research suggests that these approaches will have to be modified so that they target muscle stem cells as well as muscle fibres.

Genetic therapies, such as those made from DNA or RNA, face challenges because of the difficulty in delivering the nucleic acid to the right cells.

Rivals such as Pfizer and Sanofi are also investing, and overall financing for gene and gene - modified cell therapies reached $ 1 billion in the first quarter of 2017, according to the Alliance of Regenerative Medicine.

Stem - cell experts contacted by Nature insist that such therapies are not ready for the clinic and say that some may even endanger patients» health.

The therapy employs a virus to insert a gene for a common ion channel into normally blind cells of the retina that survive after the light - responsive rod and cone photoreceptor cells die as a result of diseases such as retinitis pigmentosa.

A fix for broken rat hearts Scientists this week successfully implanted human embryonic stem cells into rats that suffered heart attacks, coming a heartbeat closer to realizing the full potential of such therapy.

Under the proposed law, gene therapy will be approved only for the treatment of people with genetic diseases such as cystic fibrosis and will not be allowed in germ cells, where genetic alterations would be passed on to the next generation.

Ideally, therapy for autoimmune diseases should eliminate pathogenic autoimmune cells while sparing protective immunity, but feasible strategies for such an approach have been elusive.

Because diseases such as cancer tend to evade detection by T - cells» receptors, allowing a tumor to grow unchecked, scientists have long sought «intel» on this process as a means of developing therapies that target malignant cells, but leave healthy cells alone.

Because RNA carries the genetic message from DNA to the cell's proteinmaking factories, or can directly perform acts such as gene regulation, it, too, is an appealing target for therapies.

One solution might be, however, using gene therapy to stimulate such reprogramming of cells and thus to strengthen the self - healing abilities of the heart.

The enzyme therapy also inhibited sunburn symptoms such as reddening and death of skin cells.

Such rapid and extensive degradation suggests that conjugates may be able to prevent or hinder cancer cells from developing resistance to targeted therapies, the researchers state.

Hydrogels, noted for their biomimetic properties, are the leading materials for biomedical applications, such as drug delivery and stem cell therapy.

«Our researchers were able to identify a change in a specific mark in the proteins that wrap the DNA — called histones — in such a way that makes repair much faster in cancer cells, increasing their resistance to therapy.»

B cell signaling pathways are the current targets of several therapies used to treat B cell malignancies such as CLL.

He hopes that Cas9 - based therapies for T cell - related disorders, which include autoimmune diseases as well as immunodeficiencies such as «bubble boy disease,» will enter the clinic in the future.

She says that even though Sasai's team hasn't yet grown an entire eyeball in a dish, the work shows that it's possible to grow specific eye structures, such as retinas, from stem cells in a great enough quantity that they could be used in therapy.

Technology such as this, scientists said, may have a promising future in the identification and surgical removal of malignant tumors, as well as using near - infrared light therapies that can kill remaining cancer cells, both by mild heating of them and generating reactive oxygen species that can also kill them.

In further studies, they plan to explore the role of autophagy in immune reactions toward other tumor cell types, to determine whether such therapies might be effective in a broad range of cancers.

Indeed, inhibiting CXCR4 function systemically with the small molecule antagonist plerixafor results in the peripheral mobilization of hematopoetic stem cells, thus mitigating the potential of such therapy for long - term anti-retroviral therapy.