Sentences with phrase «cell therapy approach»

«The development of a functional human kidney glomerulus chip opens up an entirely new experimental path to investigate kidney biology, carry out highly personalized modeling of kidney diseases and drug toxicities, and the stem cell - derived kidney podocytes we developed could even offer a new injectable cell therapy approach for regenerative medicine in patients with life - threatening glomerulopathies in the future,» said Ingber.

As the first approach lies beyond the scope of this database, further details of the cell therapy approach, including, to some extent, tissue engineering, are provided below.

Early clinical evidence with the PEC - Encap product supports the potential of the replacement cell therapy approach.

Dr. Stoddart's main research focus is using autologous stem cells and gene transfer to repair musculoskeletal tissues using a cell therapy approach.

«These findings stimulate new avenues for cell therapy approaches for regenerative medicine,» said Douglas Millay, PhD, study senior investigator and a scientist in the Division of Molecular Cardiovascular Biology at Cincinnati Children's.

«You could imagine developing drugs that protect these telomerase - expressing cells, or ways to use cell therapy approaches to renew livers,» said Artandi.

Each Disease card in LifeMap Discovery includes a brief disease description, a detailed description of the current cell therapy approaches, list of cell therapies affiliated with the specific disease and relevant references.

Not exact matches

No. 4: CAR - T takes a backseat Research into chimeric antigen receptor T - cell (CAR - T) therapy has captured the attention of investors over the past two years, but safety risks could emerge as trial sizes increase, and that could help shift attention to other promising anti-cancer approaches, including NantKwest's (NASDAQ: NK) natural killer cell approach and soon - to - IPO Editas» CRISPR / Cas approach.

By targeting the affected cells instead of the virus, the approach could also cut the chances of the virus becoming resistant to the therapy, researchers say.

Inhibitory cell - based neuro - therapy is a new approach and has shown promise to date in early animal studies, warranting further development,» says Cory Nicholas, a co-first author.

Only recently have cell and gene therapy begun to triumph, by borrowing from and blending into each other's approaches.

«This newer, coupled approach gives us hope that personalized cell therapies could be an important option for high - risk CLL patients on these types of drugs.»

«These approaches,» said Sudharsan, «may help sustain photoreceptor cells for the time period needed to develop a specific gene therapy.»

Research on metastatic colorectal cancer and sarcoma, however, suggests a potential benefit from adding local therapy — treatment directed specifically at the tumor cells — to the standard approach of systemic therapy.

While the disease can take many forms, recent advances have better characterized how lymphoma cells proliferate and interact with other cells and tissues, leading to the development of powerful, targeted therapies with fewer side effects than traditional approaches.

Most approaches for regenerative therapy for the heart use stem cells or gene therapy.

«Researchers ID cancer gene - drug combinations ripe for precision medicine: Yeast, human cells and bioinformatics help develop one - two punch approach to personalized cancer therapy.»

Existing approaches to delivering DNA into cells for producing these gene therapies include viruses, external electrical fields or harsh chemical reagents.

Geron explores many therapies related to aging, including cell - based approaches to chronic diseases.

His team's approach is based on gene therapy, where a «tame» virus is harnessed to transfer a gene into target cells in the recipient.

In yet another approach, researchers could modify specific white blood cells (called T - cells) to see and target pancreatic cancer cells, although this therapy could attack healthy cells, too.

Dr. Cooper joined MDACC in 2006 as section chief of cell therapy at the Children's Cancer Hospital, where he cared for children undergoing bone marrow transplantation and led scientific efforts to develop new treatment approaches that pair genetic engineering with immunotherapies.

Kohn's gene therapy approach using HSC from patient's own blood is a revolutionary alternative to current SCD treatments as it creates a self - renewing normal blood cell by inserting a gene that has anti-sickling properties into HSC.

Experimental approaches such as gene therapy are also being investigated, but Dr. Rudnicki's research suggests that these approaches will have to be modified so that they target muscle stem cells as well as muscle fibres.

A study published January 4th in Cell Stem Cell demonstrates that a gene therapy approach can lead to the long - term survival of functional beta cells as well as normal blood glucose levels for an extended period of time in mice with diabetes.

When the selected isotope also contributes to the decay of cancer cells, the approach is known as «theranostics» (therapy and diagnostics).

Ideally, therapy for autoimmune diseases should eliminate pathogenic autoimmune cells while sparing protective immunity, but feasible strategies for such an approach have been elusive.

Researchers found the gene therapy approach had stronger results when used in combination with either depletion of immunosuppressive cells from the tumor mass or with immune checkpoint blockade.

This therapeutic approach uses the body's own T cells to attack tumors — but often the therapy is unreliable.

The team designed a different approach to study the therapy in myeloma, adding in an infusion of the patient's own stem cells along with their lymphodepleting chemotherapy (melphalan), followed by CTL019 infusion about two weeks later.

With this novel approach, the researchers found that the therapy reduced the virus in the brain, preventing harm to nerve cells.

The research team found that when a particular mitochondrial fission protein (GTPase dynamin - related protein - 1 — Drp1) was blocked using either gene - therapy or a chemical approach in experimental models of PD in mice, it reduced both cell death and the deficits in dopamine release — effectively reversing the PD process.

Next, the team plans to reproduce the research in human cells; if successful, the approach could lay the groundwork for therapies for a wide array of myelin disorders and spinal cord injury.

If the approach also works with human cells, it could eventually lead to cell therapies for diseases like inherited leukodystrophies — disorders of the brain's white matter — and multiple sclerosis, as well as spinal cord injuries.

Researchers have now found a way to map those alternate routes by studying individual cancer cells, suggesting approaches for developing more effective combination therapies.

When tested in laboratory samples of leukemia cells and in animals with human - like leukemia, the approach caused cancer cells to die much more quickly than with conventional targeted therapies.

This visual abstract depicts how Wei et al. utilize single - cell phosphoproteomic analysis of patient derived glioblastoma models to identify shifts in signaling coordination following short - term treatment with kinase inhibitors, which facilitates the design of combination therapy approaches with reduced resistance and improved efficacy.

The results from our new study suggest that entinostat may enhance the anti-tumor efficacy of PD - 1 targeted therapy through MDSC targeting, potentially providing an effective combination treatment approach for patients with solid tumors, including lung and renal cell carcinoma.»

«Disjointed: Cell differences may explain why rheumatoid arthritis varies by location: Findings point to new approaches in targeted therapies so that what works for arthritic hands may not be the same for ailing hips.»

Researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem — Inserm / AFM / UEVE), in collaboration with CNRS and Paris Descartes University, have recently developed a new approach to better control the differentiation of human pluripotent stem cells, and thus produce different populations of motor neurons from these cells in only 14 days.

«Electrical mobilization and guidance of stem cells in the brain therefore provides a potential approach to facilitate stem cell therapies for brain diseases, stroke and injuries,» Zhao said.

This approach for gene therapy to treat fatty liver disease, for example, might prove both safer and more effective than reengineering cells in the liver itself.

The new findings, published online in the journal Molecular Cancer Therapeutics, show that combining rapamycin with a gene therapy approach enhanced the animals» ability to summon immune cells called CD8 + T cells to kill tumor cells directly.

Inserm researchers at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem — Inserm / French Muscular Dystrophy Association [AFM] / University of Évry Val d'Essonne [UEVE]-RRB-, in collaboration with CNRS and Paris - Descartes University, have developed an innovative approach to study the differentiation of human stem cells and thus produce many types of cells in an optimal manner.

Chi said the new understanding of autophagy's role in regulatory T cells could enable a two-fold approach to immune therapy for cancers.

A new model for post-integration latency in macroglial cells to study HIV - 1 reservoirs of the brain, AIDS, DOI: 10.1097 / QAD.0000000000000691 Link to the original publication As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus and lung diseases.

A new study in the American Journal of Physiology — Heart and Circulatory Physiology reports a more practical approach called microsphere therapy that can be kept on - hand and administered more readily than stem cells.

An alternative approach is to persuade the immune system to attack tumours, using vaccines, biological therapies such as alpha interferon or interleukin 2 and genetically altered white blood cells.

«RNAi therapies are a unique approach to cancer treatment as they have the potential to «turn off» the genes» coding for proteins involved in cancer cell division,» said Ramesh K. Ramanathan, M.D., medical director of the Virginia G. Piper Cancer Center Clinical Trials Program at Scottsdale Healthcare and deputy director of the Clinical Translational Research Division of the Translational Genomics Research Institute (TGen) in Phoenix, Ariz. «Using a lipid nanoparticle, the RNAi drug can be delivered to a cancer cell to block the expression of specific proteins involved in tumor growth.»

«Analysis of metastatic prostate cancers suggests treatment options: Study maps out abnormal signaling pathways in prostate cancer cells and provides computational approaches to identify individualized targets for therapy.»