Sentences with phrase «cell therapy methods»

Scientists developing new cell therapy methods for the treatment of disorders such as sickle cell disease or leukemia need to consider how their culture conditions may affect the success of their translational research.

The experimental and clinical studies show that different cell therapy methods lead to different results of efficiency.

Not exact matches

But as new methods of genetic modification emerge, both the scientific and the sports communities are becoming increasingly aware that gene therapy — the insertion of genes into an individual's cells and tissues — will make its way onto the playing field.

Researchers, led by Joshua Mayourian at the Icahn School of Medicine at Mount Sinai, used mathematical modeling to simulate electrical interactions between these stem cells and heart cells to develop insight into possible adverse effects, as well as to hypothesize new methods for reducing some potential risks of this therapy.

With these in vitro test methods, the KU researchers have shown that anti-CD44s antibody can reduce pancreatic cancer cell growth, metastasis and ability of the tumors to recur after radiation therapy.

In addition to providing insights regarding selection of treatment, this blood test may also prove helpful in assessing the presence of residual disease, recurrence, or relapse and detection of therapy - resistant cancer cells more quickly than conventional tissue - based methods.

«By reprogramming human cells, scientists have created new opportunities to study diseases and develop methods for diagnosis and therapy,» the Nobel judges wrote.

They do not yet form the basis for a therapy, researchers said, because methods must still be perfected to get them more selectively into the cancer cells.

«Cell - weighing method could help doctors choose cancer drugs: Technique may predict which therapies a patient is most sensitive or resistant to.»

«Preventing cell death from infection: Scientists demonstrate powerful method to find new therapies.»

This method, known as targeted radionuclide therapy, or TRT, involves the use of molecules labeled with radioactive atoms that are injected into patients and localized in cancer cells.

The researchers say their method offers a new explanation for how to prevent cancer cells from becoming treatment - resistant and how combinations therapies can be developed to overcome drug resistance.

While this promising treatment method has been intensively researched over many years, there has so far been only limited practical success in endogenous stem cell therapy.

Robert Beall becomes CEO of the CFF and, grasping the limitations of gene therapy, invests $ 3.2 million in Aurora Biosciences Corp., where cell physiologist Paul Negulescu begins to look for a chemical cure using high - throughput methods to test large numbers of potential drugs.

However, the study led by Pyle found that the current methods are inefficient; they produce immature cells that are not appropriate for modeling Duchenne in the laboratory or creating a cell replacement therapy for the disease.

However, a method to generate cells that are fully mature — a crucial prerequisite for life - saving therapies — has proven far more difficult.

Ultimately, this knowledge will be useful for understanding the very early events in human development, which are reflected in the naïve and primed stem cell states, and could also lead to improved methods to reprogram human cells for stem cell - based therapies.

So we want to look at possible methods and therapies to activate the T - cells when they need to work,» said Sotomayor.

Although we agree that greater investments are needed in the clinical development of these therapies, we disagree with the authors» suggestion that, relative to embryonic stem cells, adult stem cells provide a superior vehicle for cell - based therapies because they lack tumorigenic activity, can be prepared by methods approved by the Food and Drug Administration (FDA), and have been free of ethical controversy.

This should also enable commercialization of medical devices, reagents, and other products required for cell therapies through the development and dissemination of innovative methods and procedures for regenerative medicine based products.

«The objective of the Clinical Cell Therapy Program is to develop new methods to regrow heart muscle and blood vessels, and evaluate the efficacy of these methods as an approach to improving heart function in patients with a variety of heart disorders,» said Anthony DeMaria, M.D., director of the Sulpizio Family Cardiovascular Center at UC San Diego.

The cell processing track aims at reproducible, safe and sustainable methods applicable in manufacturing settings for cell - based products intended for cellular therapy.

Based on positive results produced from a number of scientific clinical trials, coronary artery disease therapy using adult stem cells is a promising new method of treatment for coronary artery disease patients.

The only plausible methods of repairing stochastic nuclear DNA damage look to be the aforementioned advanced molecular nanotechnology, something that lies some decades in the future, or major advances in gene therapy, to the point at which it could be cost - effective and safe to scan and conditionally alter the majority of genes in the majority of cells all at once.

Lentiviral - based gene therapy methods to modify human CD34 + hematopoietic stem cells have been investigated as a way of treating various hematological disorders including X-linked chronic granulomatous disease (X-CGD).

The Bulte Lab has developed methods to label cells magnetically using tiny superparamagnetic iron oxide nanoparticles in order to make them visible by magnetic resonance imaging; this technology has now been introduced in the clinic for several cell therapy applications.

The results described in Cell Reports underscore the value of the single cell method to evaluate tumor therCell Reports underscore the value of the single cell method to evaluate tumor thercell method to evaluate tumor therapy.

Dr. Kim's lab also investigates translational stem cell research and personalized cell therapy of PD and is optimizing reprogramming and differentiation methods.

Summary: University of Chicago researchers have developed the first practical method to limit activity of therapeutic genes to a specific cell type (smooth muscle cells), clearing a major safety hurdle facing gene therapy.

The new iPS cells generated using novel methods may represent biomedically - and clinically - ideal cells, providing potential platforms for studying human disease mechanisms and achieving the long - term goal of personalized cell - replacement therapy.

September 1, 1997 Targeting gene therapy to specific cells Researchers at the University of Chicago Medical Center have developed the first practical method to restrict the activity of genes used for gene therapy to a specific cell type.

LA JOLLA, CA — A new method for generating stem cells from mature cells promises to boost stem cell production in the laboratory, helping to remove a barrier to regenerative medicine therapies...

The scientists say their method, which repairs the beta - globin gene (HBB), avoids gene therapy techniques that can introduce potentially harmful genes into cells.

The method, called «theranostic» imaging, targets potent drug therapies directly and only to cancer cells while also tracking and monitoring the journey.

In two new publications in the journal Molecular Therapy, University of Cincinnati (UC) biomedical engineering professor Peixuan Guo, PhD, details successful methods of producing large RNA nanoparticles and testing their safety in the delivery of therapeutics to targeted cells.

Novocell has developed and proven methods to efficiently generate pancreatic, insulin - producing cells from hESCs, demonstrating for the first time that hESCs could serve as a source of cellular therapy for diabetes.

Developing methods to deliver cells and to reduce contamination of hESC - derived product preparations are major concerns impacting the development and application of stem cell therapies,» said Emmanuel Baetge, Ph.D., Senior Vice President and Chief Scientific Officer of Novocell.

And because each cell has its own unique set of mutations, we can not solve them with the methods of gene therapy in the adult organism either today or tomorrow.

Using state - of - the - art proteomics and associated computational methods, the Speicher laboratory is investigating protein changes associated with ovarian cancer, melanoma, cardiac injury resulting from breast cancer therapies, ectopic pregnancy, red cell diseases, and other clinical disorders.

All these methods pave the way for stem cell therapies for a plethora of conditions.

Yes, I'm sticking to the fringe stuff early in this chapter — and stem cell therapy certainly is another potent recovery method that flies under the radar.

4) Gene therapy is a set of methods that uses genes to treat or prevent disease by inserting genes into a patient's cells.

While osteoarthritic conditions are rather difficult to treat, stem cell therapy offers an effective alternative for pets that have not tolerated or responded well to medication, are not good surgical candidates, require long - term pain management, and / or for whom a natural therapy is a preferred method of treatment.

Our veterinarians implement this revolutionary method of pet therapy by taking «blank slate» cells and using them to treat spinal cord, bone, ligament, and tendon injuries.

Preparation and global prosecution of patent applications directed to diagnostic and therapeutic products including antibodies, gene therapies, vaccines, stem cells, pharmaceutical formulations, nanotechnology, nucleic acid molecules, biologics, medical devices, mouse platforms for antibody development, and methods of treating diseases.