Sentences with phrase «cell transcription factor»

The Regulatory T - cell Transcription Factor Foxp3 Protects against Crescentic Glomerulonephritis.

The T cell transcription factor NFATp is a substrate for calcineurin and interacts with the DNA - binding domains of Fos and Jun..

In this study, the researchers found that conditional deletion of Sox2 — the gene encoding the SOX2 stem cell transcription factor — and the associated dampening of astrocyte reactivity appear to promote functional recovery, including behavioral recovery, after traumatic brain injury, said Dr. Zhang, a W.W. Caruth, Jr..

The stem cell transcription factor SOX2, which is critical for stem cells, cell reprogramming, and brain development, also is activated in astrocytes in the adult brain.

«We wanted to understand how stem cell transcription factors were interconnected and explain how these cells behave in different culture conditions and still maintain the stem cell state,» said Smith.

Not exact matches

Combating inflammation According to the JNCI, Capsaicin blocks the activation of nuclear transcription factors in the cells» nuclei that, when activated by exogenous or endogenous free radicals or toxins, cause inflammation throughout the stomach and body.

The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult mouse endothelial cells, which line the inside of blood vessels, to turn into HSCs.

The Cincinnati Children's team suspects that the EBNA2 transcription factor from EBV is helping change how infected B cells operate, and how the body responds to those infected cells.

«But in this case, when this virus infects cells, the virus makes its own transcription factors, and those sit on the human genome at lupus risk variants (and at the variants for other diseases) and that's what we suspect is increasing risk for the disease.»

Adding seven transcription factors — proteins that switch on genes — the team then converted the IPSCs into immature HSC - like cells.

The ATF6 protein is a transcription factor, meaning it helps turn other genes «off» or «on,» depending on what's needed by the cell.

Boldrini says that future research on the aging brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.

They took a naturally occurring mitochondrial transcription factor called TFAM, which initiates protein synthesis, and engineered it to cross into cells from the bloodstream and target the mitochondria.

Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.

M. J. Bertram et al., Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor - like genes.

While the process usually proceeds in a one - way direction, artificially inducing the activity of key transcription factors can reprogram differentiated cells back into a stem - like state, a discovery honored with the 2012 Nobel prize.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

In the journal Cell Reports, published today online, the scientists describe how the powerful master regulatory transcription factor Bcl6 regulates the genome, ensuring that aggressive lymphomas survive and thrive.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

«Transcription factors distinguishing glioblastoma stem cells identified.»

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kiTranscription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kitranscription factors on steroids: their actions regulate thousands of genes in different kinds of cells.

The study team removed fibroblasts (skin cells) from DBA patients, and in cell cultures, using proteins called transcription factors, reprogrammed the cells into iPSCs.

In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cells.

Their work elucidates a dynamic, two - step mechanism in females whereby B cells lacking the markers of X chromosome inactivation regain these modifications during B cell activation, in a process involving the transcription factor YY1.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Once inside the myofibroblasts, the virus downloads the transcription factors, which transform the cells into hepatocytes.

Although transcription factors are often the ingredients scientists use to induce stem cell fate, Dalby and Ulijn hypothesize that certain metabolites «fuel» the pathways that result in variable concentrations of transcription factors that drive these changes.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

The limitation of ChIP - seq is that it can not deliver a conclusive picture of transcription factor binding in a single cell because it samples events in a population after the cells have been exposed to various toxic chemicals.

Disease processes often begin with mutations in the transcription factor, or in the DNA they bind to inside the nucleus of cells to regulate the complex interplay of genes needed for a healthy functioning body.

To understand defective disease process, investigators need to track where and how transcription factors bind to DNA to identify the differences between healthy and diseased cells.

Eventually, she says, it might be possible to use our increased understanding of RFX transcription factor to treat hearing loss, by either protecting hair cells from death or fostering their growth.

DNA binding proteins called transcription factors are required for maintaining cell identity.

Each cell type can be distinguished based on its transcription factors, and a cell can in certain cases be directly converted from one type to another, simply by changing the expression of one or more transcription factors.

«Absence of a transcription factor halts tooth development in mid-stride: Without the transcription factor Sp7, two specialized types of cells that create dentin and enamel fail to mature.»

However, each time a cell divides the specific binding pattern of the transcription factors is erased and has to be restored in both mother and daughter cells.

The research group has produced the most complete map yet of transcription factors in a cell.

«The problem is that there is so much DNA in a cell that it would be impossible for the transcription factors to find their way back within a reasonable time frame.

The current study identified a new role for a particular group of proteins, known as RFX transcription factors, in the development and survival of the hair cells.

First author Adam Skibinski, M.D. / Ph.D., student at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University, said «We've known for a long time that breast cells can lose their normal identity when they become cancerous, but we are now realizing that normal cells can change their characteristics as well in response to transcription factors like TAZ.

The scientists then moved on to study mice which had been genetically altered so that their hair cells lacked two of the RFX transcription factors.

A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

Abnormal and uncontrolled production of this class of proteins, known as transcription factors, allow for cells to bypass growth control mechanisms and to develop characteristics necessary for invading surrounding tissues.

If an engineered organism mates with a wild counterpart, the transcription factors render the offspring unable to survive by activating genes that cause their cells to die.

In this case, it was not by using a special formula of transcription factors, but by inducing damage to tell the body to repair itself and that it needs new cells of a certain type to do that.

The activation dynamics of the transcription factor NF - κB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis factor — α (TNFα) but stable behavior when stimulated by lipopolysaccharide (LPS).

Glk1 is a transcription factor, meaning it binds to specific regions of DNA and activates genes involved in cell death and other plant immune responses.

An international consortium under the leadership of Prof. Dr. Thomas Laux, a biologist from the University of Freiburg, has identified the transcription factor WUSCHEL HOMEOBOX (WOX) 5 as the signal molecule, showing that it moves through pores from the cells inside the quiescent centre into the stem cells.

The study, which can be read in Nature Communications, shows the transcription factor family MYB3R prevents progression to the division stage (M phase) of the cell cycle in Arabidopsis, a small flowering plant that is a member of the mustard family.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.