At Roswell Park, along with his translational lab research, Dr. Koya leads an NIH funded prospective clinical trial based on an immune - modulator - enhanced TCR - engineered T
cell transfer for metastatic cancer patients.
Not exact matches
The OAR proposal uses a variation of therapeutic cloning called altered nuclear
transfer (ANT) in which the nucleus of a donor
cell (a skin
cell,
for example), containing the 30,000 genes of the genetic code, is altered in such a way that it produces an epigenetic factor, a protein called nanog.
This may entail making small holes in the bone to allow new cartilage to grow (microfracture), taking cartilage from another part of the athlete's knee and transplanting it into the defect (osteochondral autograft
transfer), taking cartilage
cells from the knee and then having them grown in a lab
for later re-implantation (autologous chondrocyte implantation), or taking cartilage from a person who has passed away and placing it in the defect (osteochondral allograft
transfer).
Last night, my State Governor, Dr. Abdulfatai Ahmed revealed to me an information at his disposal that a group of suspects who had been in police
cells for several weeks
for cultism and whose investigation had been concluded with prosecution about to commence under the State law based on the advice of the Director of Public Prosecution (DPP) and the Ministry of Justice were ordered to be
transferred to Abuja this morning.
One of the latest twist of the story told on Wednesday was by Senate President Saraki who announced that his State governor and ally, Abdulfatai Ahmed had told him that a group of suspects who had been in police
cells for several weeks
for cultism and whose investigation had been concluded with prosecution about to commence under the State law based on the advice of the director of public prosecution (DPP) and the Ministry of Justice, were ordered to be
transferred to Abuja on the directive of IGP) Idris Ibrahim.
To help make ideas about energy more concrete,
for example, the new unit will use a variety of analogies from more familiar physical systems (e.g., combustion and charging a cellphone battery) to help students understand those same energy - releasing and energy - requiring chemical reactions and energy
transfer when they occur in living organisms (e.g., cellular respiration, creating a charge across a membrane in mitochondria and nerve
cells) where the reactions are more complex and difficult to observe.
TWICE THE FUN Zhong Zhong and Hua Hua, the first primates successfully cloned via somatic
cell nuclear
transfer, are healthy, playful and, so far, completely normal
for baby macaques.
Thus, transport of peptide — MHC II complexes by DCs not only accomplishes
transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory molecules
for T
cell contact.
In the final analysis, it seems clear that Geron is not going
for the obvious play, pairing stem
cells and nuclear
transfer to pursue human clones.
This has potential applications
for cell replacement without the immunosuppression treatments that are required when
cells are
transferred between genetically different individuals.
This group of about 800 receptors plays a central role in
transferring signals from the environment into the
cell and is of great interest
for drug development.
The capsule creates the biotechnical condition
for it, because it separates the donator's
cells from the body of the receiver and
transfers the hormones which are important
for the metabolism exclusively «In the eyes of Dresden scientists this kind of transplantation will be suitable
for patients with adrenal insufficiency but also with congenital diseases such as the lack of 21 - hydroxylase.
«We think that differentiation is a way that opens some doors and makes it easier
for nuclear
transfer programming to go back into embryonic stem
cells.»
Some scientists, such as Kevin Eggan at Harvard, were disappointed that NIH didn't open the door to the use of embryos created
for research purposes — including through somatic
cell nuclear
transfer (cloning) and parthenogenesis (from an unfertilized egg).
Day 0: Around 9,000 stem
cells are
transferred into V - shaped wells and suspended in a cocktail of vitamins, amino acids and (
for the first six days) Y - 27632, a chemical to prevent the stem
cells from committing suicide.
Stem
cell researchers call them «a major step in the right direction,» although some were disappointed that NIH didn't open the door to the use of embryos created
for research purposes — including through somatic
cell nuclear
transfer (cloning) and parthenogenesis (from an unfertilized egg).
But they still want to be able to do cloning, otherwise know as somatic
cell nuclear
transfer (SCNT), because embryonic
cells are the «gold standard»
for pluripotent
cells —
cells that can become any
cell type in the body.
Adoptive
cell transfer procedures are mimicking exactly this process in a culture dish by taking T
cells from patients, multiplying them, sometimes genetically modifying them, and then returning them to patients so that they can,
for example, locate and kill cancer
cells.
«By identifying the signals that instruct mouse progenitor
cells to become
cells that make tubes and later insulin - producing beta
cells, we can
transfer this knowledge to human stem
cells to more robustly make beta
cells, says Professor and Head of Department Henrik Semb from the Novo Nordisk Foundation Center
for Stem
Cell Biology at the Faculty of Health and Medical Sciences.
The University of Hawai'i Office of Technology
Transfer and Economic Development (OTTED) has filed a provisional U.S. patent application
for the new
cell - sorting method, «Surface Free Energy Based Particle Sorting.»
Because the antigens were the only possible source of TB exposure, Dr. Srivastava says, antigen
transfer from infected dendritic
cells had to be the avenue
for their absorption by other immune system
cells in the lymph nodes.
During surgery, melanocyte skin
cells responsible
for giving color to the skin, hair and eyes are harvested from healthy, pigmented areas of the body and
transferred to an area that lost its pigment.
Although in rare cases mitochondrial genes may be
transferred to the nucleus of a
cell, she said the IU team found no evidence to suggest this is the case in V. scurruloideum, and that further investigation will be required to reveal the exact mechanism through which the species compensates
for its missing genes.
Intrigued by the ability of certain polymers to mop up DNA and RNA
for gene
transfer, Sullenger and colleagues tested the idea that these chemical compounds might also be effective targeting such nucleic acids as they arise in
cell death.
A team of researchers led by North Carolina State University has found that stacking materials that are only one atom thick can create semiconductor junctions that
transfer charge efficiently, regardless of whether the crystalline structure of the materials is mismatched — lowering the manufacturing cost
for a wide variety of semiconductor devices such as solar
cells, lasers and LEDs.
PARTICLE acts in three different ways to prevent expression of the MAT2A gene: 1) by winding around the MAT2A gene to create a DNA: RNA triple helix structure locking down the MAT2A gene promoter, 2) by binding the messenger RNA product of the MAT2A gene and preventing it being used
for MAT2A protein synthesis and 3)
transferring MAT2A messenger RNA into intracellular vesicles that are subsequently ejected from the
cell.
A quasiparticle called an exciton — responsible
for the
transfer of energy within devices such as solar
cells, LEDs, and semiconductor circuits — has been understood theoretically
for decades.
And if the
cells prove to be functional enough
for nuclear
transfer but not
for producing offspring, they might refute one of the main arguments against therapeutic cloning: that it creates embryos only to destroy them.
That was enough time
for the team to
transfer new nuclei into dozens of egg
cells.
«The value of acoustic tweezers
for studying
cell - to -
cell information
transfer is their ability to separate the
cells to a precise distance or to bring them to a predetermined contact,» said Stephen J. Benkovic, Evan Pugh Professor and Eberly Chair in Chemistry.
«They play an important role in the excitation of nerve
cell axons and signal
transfer between various
cells,» says Prof. Dr. Heinz Beck, who conducts research in experimental epileptology at the Department of Epileptology, at the Life & Brain center and the German Center
for Neurodegenerative Diseases (DZNE).
The researchers found that many of the genes the phages carry and
transfer are beneficial to the bacteria; some may help them repair
cell walls,
for example.
By
transferring the gene
for melanopsin into human embryonic kidney
cells, synthetic biologist Martin Fussenegger of the Swiss Federal Institute of Technology in Zurich and colleagues made these
cells light - sensitive as well.
Haile's team will also investigate making the fuel
cells reversible, which would
transfer electricity back into hydrogen
for placement on grid backup.
We have observed on several occasions that,
for the majority of endothelial
cell lines, the
transfer to 37 °C conditions
for 72 h correlated with a 50 % reduction in
cell proliferation, a value that continued to decrease with time.
For example, if phosphate in ATP was exchanged for arsenate, would the energy - transfer reaction that powers a cell be as efficie
For example, if phosphate in ATP was exchanged
for arsenate, would the energy - transfer reaction that powers a cell be as efficie
for arsenate, would the energy -
transfer reaction that powers a
cell be as efficient?
He now juggles two jobs: he is a project manager
for the University of Oxford's technology
transfer subsidiary ISIS Innovation, as well as managing director of one of its break - out firms, Zyoxel, which develops simple microbioreactors, devices that enable cost - effective 3D
cell culture.
Since their discovery in the 1950s,
transfer RNAs (tRNAs) have been best known
for their role in helping the
cell make proteins from messenger RNA templates.
Based on the mutated DNA, affected
cells create long strands of repetitive RNA, genetic material normally responsible
for transferring DNA's genetic code outside the nuclei, to the machinery that translates it into proteins.
Having shown that chemically modified magnetite (Fe2CrO4) meets the basic criteria required
for an air stable, visible light photocatalyst, the investigators plan to carry out experiments in which they will
transfer freshly grown Fe2CrO4 surfaces to a photoelectrochemical
cell under a dry nitrogen atmosphere to avoid picking up surface carbon contamination.
She identified that specific killing of myeloid
cells represents an additional mechanism of suppression mediated by Tr1
cells, and she contributed to the definition of a new protocol
for Tr1
cell induction using IL - 10 gene
transfer and in the discovery of the biomarkers of Tr1
cells.
Since then he has continued to investigate new strategies to overcome the major hurdles to safe and effective gene
transfer, translate then into new therapeutic strategies
for genetic disease and cancer, and allowed new insights into hematopoietic stem
cell function, induction of immunological tolerance and tumor angiogenesis.
g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. AD 129 — c. 216) galena GALEX (Galaxy Evolution Explorer) Galilean satellites Galilean telescope Galileo (Galilei, Galileo)(1564 — 1642) Galileo (spacecraft) Galileo Europa Mission (GEM) Galileo satellite navigation system gall gall bladder Galle, Johann Gottfried (1812 — 1910) gallic acid gallium gallon gallstone Galois, Évariste (1811 — 1832) Galois theory Galton, Francis (1822 — 1911) Galvani, Luigi (1737 — 1798) galvanizing galvanometer game game theory GAMES AND PUZZLES gamete gametophyte Gamma (Soviet orbiting telescope) Gamma Cassiopeiae Gamma Cassiopeiae star gamma function gamma globulin gamma rays Gamma Velorum gamma - ray burst gamma - ray satellites Gamow, George (1904 — 1968) ganglion gangrene Ganswindt, Hermann (1856 — 1934) Ganymede «garbage theory», of the origin of life Gardner, Martin (1914 — 2010) Garneau, Marc (1949 ---RRB- garnet Garnet Star (Mu Cephei) Garnet Star Nebula (IC 1396) garnierite Garriott, Owen K. (1930 ---RRB- Garuda gas gas chromatography gas constant gas giant gas laws gas - bounded nebula gaseous nebula gaseous propellant gaseous - propellant rocket engine gasoline Gaspra (minor planet 951) Gassendi, Pierre (1592 — 1655) gastric juice gastrin gastrocnemius gastroenteritis gastrointestinal tract gastropod gastrulation Gatewood, George D. (1940 ---RRB- Gauer - Henry reflex gauge boson gauge theory gauss (unit) Gauss, Carl Friedrich (1777 — 1855) Gaussian distribution Gay - Lussac, Joseph Louis (1778 — 1850) GCOM (Global Change Observing Mission) Geber (c. 720 — 815) gegenschein Geiger, Hans Wilhelm (1882 — 1945) Geiger - Müller counter Giessler tube gel gelatin Gelfond's theorem Gell - Mann, Murray (1929 ---RRB- GEM «gemination,» of martian canals Geminga Gemini (constellation) Gemini Observatory Gemini Project Gemini - Titan II gemstone gene gene expression gene mapping gene pool gene therapy gene
transfer General Catalogue of Variable Stars (GCVS) general precession general theory of relativity generation ship generator Genesis (inflatable orbiting module) Genesis (sample return probe) genetic code genetic counseling genetic disorder genetic drift genetic engineering genetic marker genetic material genetic pool genetic recombination genetics GENETICS AND HEREDITY Geneva Extrasolar Planet Search Program genome genome, interstellar transmission of genotype gentian violet genus geoboard geode geodesic geodesy geodesy satellites geodetic precession Geographos (minor planet 1620) geography GEOGRAPHY Geo - IK geologic time geology GEOLOGY AND PLANETARY SCIENCE geomagnetic field geomagnetic storm geometric mean geometric sequence geometry GEOMETRY geometry puzzles geophysics GEOS (Geodetic Earth Orbiting Satellite) Geosat geostationary orbit geosynchronous orbit geosynchronous / geostationary
transfer orbit (GTO) geosyncline Geotail (satellite) geotropism germ germ
cells Germain, Sophie (1776 — 1831) German Rocket Society germanium germination Gesner, Konrad von (1516 — 1565) gestation Get Off the Earth puzzle Gettier problem geyser g - force GFO (Geosat Follow - On) GFZ - 1 (GeoForschungsZentrum) ghost crater Ghost Head Nebula (NGC 2080) ghost image Ghost of Jupiter (NGC 3242) Giacconi, Riccardo (1931 ---RRB- Giacobini - Zinner, Comet (Comet 21P /) Giaever, Ivar (1929 ---RRB- giant branch Giant Magellan Telescope giant molecular cloud giant planet giant star Giant's Causeway Giauque, William Francis (1895 — 1982) gibberellins Gibbs, Josiah Willard (1839 — 1903) Gibbs free energy Gibson, Edward G. (1936 ---RRB- Gilbert, William (1544 — 1603) gilbert (unit) Gilbreath's conjecture gilding gill gill (unit) Gilruth, Robert R. (1913 — 2000) gilsonite gimbal Ginga ginkgo Giotto (ESA Halley probe) GIRD (Gruppa Isutcheniya Reaktivnovo Dvisheniya) girder glacial drift glacial groove glacier gland Glaser, Donald Arthur (1926 — 2013) Glashow, Sheldon (1932 ---RRB- glass GLAST (Gamma - ray Large Area Space Telescope) Glauber, Johann Rudolf (1607 — 1670) glaucoma glauconite Glenn, John Herschel, Jr. (1921 ---RRB- Glenn Research Center Glennan, T (homas) Keith (1905 — 1995) glenoid cavity glia glial
cell glider Gliese 229B Gliese 581 Gliese 67 (HD 10307, HIP 7918) Gliese 710 (HD 168442, HIP 89825) Gliese 86 Gliese 876 Gliese Catalogue glioma glissette glitch Global Astrometric Interferometer
for Astrophysics (GAIA) Global Oscillation Network Group (GONG) Globalstar globe Globigerina globular cluster globular proteins globule globulin globus pallidus GLOMR (Global Low Orbiting Message Relay) GLONASS (Global Navigation Satellite System) glossopharyngeal nerve Gloster E. 28/39 glottis glow - worm glucagon glucocorticoid glucose glucoside gluon Glushko, Valentin Petrovitch (1908 — 1989) glutamic acid glutamine gluten gluteus maximus glycerol glycine glycogen glycol glycolysis glycoprotein glycosidic bond glycosuria glyoxysome GMS (Geosynchronous Meteorological Satellite) GMT (Greenwich Mean Time) Gnathostomata gneiss Go Go, No - go goblet
cell GOCE (Gravity field and steady - state Ocean Circulation Explorer) God Goddard, Robert Hutchings (1882 — 1945) Goddard Institute
for Space Studies Goddard Space Flight Center Gödel, Kurt (1906 — 1978) Gödel universe Godwin, Francis (1562 — 1633) GOES (Geostationary Operational Environmental Satellite) goethite goiter gold Gold, Thomas (1920 — 2004) Goldbach conjecture golden ratio (phi) Goldin, Daniel Saul (1940 ---RRB- gold - leaf electroscope Goldstone Tracking Facility Golgi, Camillo (1844 — 1926) Golgi apparatus Golomb, Solomon W. (1932 — 2016) golygon GOMS (Geostationary Operational Meteorological Satellite) gonad gonadotrophin - releasing hormone gonadotrophins Gondwanaland Gonets goniatite goniometer gonorrhea Goodricke, John (1764 — 1786) googol Gordian Knot Gordon, Richard Francis, Jr. (1929 — 2017) Gore, John Ellard (1845 — 1910) gorge gorilla Gorizont Gott loop Goudsmit, Samuel Abraham (1902 — 1978) Gould, Benjamin Apthorp (1824 — 1896) Gould, Stephen Jay (1941 — 2002) Gould Belt gout governor GPS (Global Positioning System) Graaf, Regnier de (1641 — 1673) Graafian follicle GRAB graben GRACE (Gravity Recovery and Climate Experiment) graceful graph gradient Graham, Ronald (1935 ---RRB- Graham, Thomas (1805 — 1869) Graham's law of diffusion Graham's number GRAIL (Gravity Recovery and Interior Laboratory) grain (cereal) grain (unit) gram gram - atom Gramme, Zénobe Théophile (1826 — 1901) gramophone Gram's stain Gran Telescopio Canarias (GTC) Granat Grand Tour grand unified theory (GUT) Grandfather Paradox Granit, Ragnar Arthur (1900 — 1991) granite granulation granule granulocyte graph graph theory graphene graphite GRAPHS AND GRAPH THEORY graptolite grass grassland gravel graveyard orbit gravimeter gravimetric analysis Gravitational Biology Facility gravitational collapse gravitational constant (G) gravitational instability gravitational lens gravitational life gravitational lock gravitational microlensing GRAVITATIONAL PHYSICS gravitational slingshot effect gravitational waves graviton gravity gravity gradient gravity gradient stabilization Gravity Probe A Gravity Probe B gravity - assist gray (Gy) gray goo gray matter grazing - incidence telescope Great Annihilator Great Attractor great circle Great Comets Great Hercules Cluster (M13, NGC 6205) Great Monad Great Observatories Great Red Spot Great Rift (in Milky Way) Great Rift Valley Great Square of Pegasus Great Wall greater omentum greatest elongation Green, George (1793 — 1841) Green, Nathaniel E. Green, Thomas Hill (1836 — 1882) green algae Green Bank Green Bank conference (1961) Green Bank Telescope green flash greenhouse effect greenhouse gases Green's theorem Greg, Percy (1836 — 1889) Gregorian calendar Grelling's paradox Griffith, George (1857 — 1906) Griffith Observatory Grignard, François Auguste Victor (1871 — 1935) Grignard reagent grike Grimaldi, Francesco Maria (1618 — 1663) Grissom, Virgil (1926 — 1967) grit gritstone Groom Lake Groombridge 34 Groombridge Catalogue gross ground, electrical ground state ground - track group group theory GROUPS AND GROUP THEORY growing season growth growth hormone growth hormone - releasing hormone growth plate Grudge, Project Gruithuisen, Franz von Paula (1774 — 1852) Grus (constellation) Grus Quartet (NGC 7552, NGC 7582, NGC 7590, and NGC 7599) GSLV (Geosynchronous Satellite Launch Vehicle) g - suit G - type asteroid Guericke, Otto von (1602 — 1686) guanine Guiana Space Centre guidance, inertial Guide Star Catalog (GSC) guided missile guided missiles, postwar development Guillaume, Charles Édouard (1861 — 1938) Gulf Stream (ocean current) Gulfstream (jet plane) Gullstrand, Allvar (1862 — 1930) gum Gum Nebula gun metal gunpowder Gurwin Gusev Crater gut Gutenberg, Johann (c. 1400 — 1468) Guy, Richard Kenneth (1916 ---RRB- guyot Guzman Prize gymnosperm gynecology gynoecium gypsum gyrocompass gyrofrequency gyropilot gyroscope gyrostabilizer Gyulbudagian's Nebula (HH215)
Now, new research from the laboratory of Vaijayanti P. Kale (National Centre
for Cell Science, Pune, Maharashtra, India) has described a fascinating new approach to return lost functionality to aged mouse HSCs: the
transfer of microvesicles (MVs) containing positive regulators of autophagy derived from young mesenchymal stem
cells (MSCs)[6].
Using a novel technique to genetically modify T
cells for adoptive
transfer, Carl June, Michael Kalos, David Porter, Bruce Levine, and colleagues at the University of Pennsylvania School of Medicine achieve clinical responses in patients with chronic lymphocytic leukemia, including two complete, durable (one year) clinical responses, accompanied by in vivo expansion and long - term functional persistence of gene - modified
cells.
While Gurdon's tadpoles did not survive to grow into adult frogs, his experiment showed that the process of specialization in animal
cells was reversible, and his technique of nuclear
transfer paved the way
for later cloning successes.
Several phase I and II trials of adoptive T
cell transfer techniques are currently under way
for patients with ovarian cancer, including:
Current immunotherapies
for ovarian cancer fall into six broad categories: monoclonal antibodies; checkpoint inhibitors and immune modulators; therapeutic vaccines; adoptive T
cell transfer; oncolytic viruses; and adjuvant immunotherapies.
In the new papers, according to STAT, scientists will report that the organoids survived
for extended periods of time — two months in one case — and even connected to lab animals» circulatory and nervous systems,
transferring blood and nerve signals between the host animal and the implanted human
cells.
Mast
cells and dendritic
cells form synapses that facilitate antigen
transfer for T
cell activation.