Sentences with phrase «cell transformation in»

Not exact matches

Thus, the transition from instinct to reason results in the radical transformation of the animal into man; matter as it evolves toward the cell becomes radically transformed into living matter; and vegetative life becomes qualitatively changed into conscious life.

Adenovirus 36 has been found to encourage the transformation of adult stem cells in fatty tissue into fat cells as discussed on the daily Scientific American podcast 60 - Second Science on August 20th.

The team tested the technique on cells in culture that mimic the transformation of unspecialised white blood cells into full immune cells.

Melanoma occurs when melanocytes — cells that make pigment in skin and hair — undergo a malignant transformation.

This fits with studies we've conducted in the past in which we found that the gene primes blood stem cells for leukaemic transformation.»

«When we analyzed tissue samples in the lab, we found that exposing white fat to macrophage cells from the immune system inhibited the transformation.»

Although Herrera's group has investigated the versatility of pancreatic cells in mice, several observations in diabetic patients suggest that the human pancreas is capable of transformation too.

Even distantly related bacteria can swap genes with one another using a variety of techniques, from direct cell - to - cell transfer, called conjugation, to transformation, in which a bacterium releases snippets of DNA that other bacteria pick up and use.

In the experiment, Jiang's team fabricated a broadband active frequency - selective surface with a stretching transformation pattern on a printed circuit board, and soldered the resistors and varactors between each of the two unit patterned cells.

It has been shown to play a role in cell survival, immunity and malignant transformation.

A protein on the cell surface of P. syringae binds water in a way that mimics the structure of an ice crystal, and this helps start the transformation of cold water into ice.

Normally, the genetic switches that control the transformation of an embryo into a larva or a larva into a polyp are switched on in an order that is irreversible, «but Turritopsis cells can hit the rewind button,» Piraino explained.

As a newly hatched larva, Nyuki listens while her mentor, Dvorah («bee» in Hebrew), gently explains her impending transformation: A group of cells in her larval body will turn active, consume her from the inside out, and rebuild her as a mature bee during her imprisonment in the cocoon.

Furthermore, only those fusion - derived IEC - 6 cell clones that had undergone the changes in cellular growth indicative of neoplastic transformation produced tumors in mice.

Coleman added that further research is needed to determine whether cell fusion events between normal human cell types result in genomic catastrophe and neoplastic transformation.

A paper published in The Plant Cell reports a breakthrough in transformation technology that greatly expands the range of cultivars and species that can be transformed.

This transformation is triggered by chemical signals, which could be blocked in order to stop cancer cells from spreading.

«IGF - 1 is known to cause malignant transformations in human breast cells... and the implications have not been properly studied.»

Using a variety of methods to induce somatic cells to become iPSCs, the researchers first found that in the early stages of reprogramming, the transformation was consistently accompanied by an increase in ROS generation.

Their activation of innate immune signaling caused epigenetic changes that were absolutely necessary for the transformation of somatic cells into iPSCs,» explained Cooke, who holds the Joseph C. «Rusty» Walter and Carole Walter Looke Presidential Distinguished Chair in Cardiovascular Disease Research.

In a new Cell Reports paper, a team led by John P. Cooke, M.D., Ph.D., of the Houston Methodist Research Institute, has identified and characterized a biological factor critical to the transformation of adult somatic cells (cells that are not sperm or egg cells) into stem cells.

In addition, mature CD4 + T cells appear to be resistant to malignant transformation [54], thus mitigating the potential concerns of off - target disruption.

Subsequent experiments carried out at the Laboratory of Cell Biology in Rome by Luigi Aloe and one of us (Levi - Montalcini) demonstrated that this remarkable transformation can also take place in the intact animal: repeated injections of NGF into rat fetuses, continued for two to three weeks after birth, resulted in the differentiation of chromaffin cells into sympathetic neurons in the core of the adrenal gland!

Cancer arises from the transformation of normal cells into tumour cells in a multistage process that generally progresses from a pre-cancerous lesion to a malignant tumour.

However, when Jurkat cells are infected with HIV - 1 the proportion of cells that become latently infected vs. productively infected is small, suggesting that transformation does not result in the indiscriminate methylation and repression of HIV - 1.

However, because J - Lat cells divide autonomously and possess other aberrations associated with cellular transformation, cytosine methylation was analyzed in a recently developed primary cell model of latency [43].

T cells play a central role in regulating the cellular and humoral responses towards invading pathogens and malignant transformation.

In order to determine that the transformations work properly and the cells are safe for therapeutic use, researchers need to compare the iPS cells to ES cells, which means destroying embryos.

Moreover, following transformation with H - Ras, these cells initiated tumor xenografts in immunocompromised mice with higher efficiency than their epithelial counterparts [5].

Interestingly, suppression of Dicer activities is reported to result in promotion of epithelial - mesenchymal transistion and metastatic transformation of cancer cells.

The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.

MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three - dimensional culture.

The research offers new hope in the fight against many neurological conditions because scientists expect that such a transformation — or reprogramming — of cells may lead to better models for testing drugs for devastating neurodegenerative conditions such as Alzheimer's disease.

We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host - cell transformation, and a Theileria - specific protein domain [frequently associated in Theileria (FAINT)-RSB- present in a large number of secreted proteins.

In the October issue of Cell Stem Cell, Marius Wernig, MD, PhD, a NYSCF — Robertson Investigator at Stanford University, reported on the successful transformation of mature liver cells from laboratory mice into functioning neurons.

The Herlyn lab is differentiating multi-potent stem cells from the human dermis and reprogrammed stem cells into melanocytes to test the hypothesis that melanocyte stem cells are more prone to transformation than fully differentiated cells, and that neighboring cells and matrix in the microenvironment play critical roles in differentiation and transformation.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Melton is also a pioneer in direct cellular reprogramming research — the transformation of one type of adult cell into another, without first going through a stem cell state.

In the early 1960s Arber succeeded to explain that bacteria can distinguish between their own DNA and foreign DNA when it penetrates by viral infection, bacterial conjugation or DNA transformation into a bacterial cell.

In our laboratory, we have previously described an in vitro model of spontaneous transformation of the IL -3-dependent hematopoietic BaF3 cell line towards growth factor - independent tumorigenic clones with constitutive STAT5 activation.14 This model was developed from the study of BaF3 cells transfected with an IL - 9Rα mutant lacking the STAT - recruiting site (BaF3 phe116In our laboratory, we have previously described an in vitro model of spontaneous transformation of the IL -3-dependent hematopoietic BaF3 cell line towards growth factor - independent tumorigenic clones with constitutive STAT5 activation.14 This model was developed from the study of BaF3 cells transfected with an IL - 9Rα mutant lacking the STAT - recruiting site (BaF3 phe116in vitro model of spontaneous transformation of the IL -3-dependent hematopoietic BaF3 cell line towards growth factor - independent tumorigenic clones with constitutive STAT5 activation.14 This model was developed from the study of BaF3 cells transfected with an IL - 9Rα mutant lacking the STAT - recruiting site (BaF3 phe116).

CREBBP (CBP) and EP300 are general transcriptional co-activators, which are involved in many biological processes like maintenance of genomic stability by affecting DNA replication and DNA repair as well as cell growth, transformation and development.

Understanding the effects of Eph receptor mutations in cancer cells will help shed light on the role of the Eph receptor / ephrin system in cancer cell transformation, malignant progression and drug resistance.

The projects will provide training in: current molecular biology techniques (including RNA interference, genetic transformation, analyses of gene expression); cell biology techniques (cell culturing, cell transfections, imaging); protein biochemistry (2D electrophoresis, protein functional analyses); and bioinformatics (structure predictions, phylogenetic analyses; molecular interactions).

Additional «- omics» data streams include: transcriptomics, the pattern of RNA synthesis from DNA; proteomics, the distribution of proteins in cells; interactomics, the patterns of protein - protein and protein — nucleic acid interactions; and metabolomics, the nature and traffic patterns of transformations of small molecules by the biochemical pathways active in cells.

«While almost all the cells in our study exhibited at least a partial transformation, about 20 % of them were capable of transmitting electrical signals — a key feature of beating heart cells,» said Dr. Fu.

The presence of Stem Cells in the ovaries and their transformation into mature oocytes (egg cells) has been demonstrated in mice by Harvard researcCells in the ovaries and their transformation into mature oocytes (egg cells) has been demonstrated in mice by Harvard researccells) has been demonstrated in mice by Harvard researchers.

Together, we provide evidence that senescence and a stem cell - associated SASP drive cell transformation and tumour initiation in vivo in an age - dependent fashion.

deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo.

However, the information acquired from regular two - dimensional culturing might not be directly applied to the process of cell transformation, which is typically assayed in three - dimensional conditions.

In contrast to the transformation of HMEC - DD cells, one oncogenic event is sufficient to transform Rat1 - DD cells, indicated by both anchorage - independent growth in vitro and tumor formation in vivo (Ni et al., 2012In contrast to the transformation of HMEC - DD cells, one oncogenic event is sufficient to transform Rat1 - DD cells, indicated by both anchorage - independent growth in vitro and tumor formation in vivo (Ni et al., 2012in vitro and tumor formation in vivo (Ni et al., 2012in vivo (Ni et al., 2012).