Sentences with phrase «cell transplant recipients»

Medical Campus Hosts Annual Reunion of Stem Cell Transplant Survivors (Video) On April 10, 2010, dozens of stem cell transplant recipients and their families gathered at the University of Chicago to share their stories of survival.

Zheng is currently investigating the trigger for T cell exhaustion in AML stem cell transplant recipients.

Not exact matches

Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

As the immune cells in the recipient recognize transplanted cells as foreign, they mount an inflammatory response that can lead to the body rejecting the transplant.

Transplant recipients take rapamycin because it blocks the production of a range of different immune cells.

But first, the recipient must have their own bone marrow stem cells wiped out to make room for the transplanted donor cells.

However, to be truly useful, one must be able to transplant the bacterial chromosome from yeast back into a recipient bacterial cell.

While these islet cell transplants dramatically improved blood sugar control in the short term, all but five of the 36 recipients needed additional insulin shots within two years.

Scholl is upbeat that the transplanted cells still appear safe and says that analysis of the cells in the recipients» eyes are «indeed an indication that something is happening.»

«When we transplanted our labeled blood stem cells from the bone marrow into other mice, only a few stem cells were active in the recipients, and many stem cells were lost,» Rodewald explains.

Researchers have had some success in transplanting islet cells, but recipients require heavy doses of immune suppression.

Now a report in this month's issue of Nature Medicine may provide an explanation: A key bone marrow protein causes immune cells in mouse transplant recipients to self - destruct.

Patients who develop this specific fungal infection are overwhelmingly adults who are immunocompromised, Kumar explains, including those with diabetes, transplant recipients, patients with cancer and those who have abnormally low concentrations of immune cells called neutrophils in their blood.

They also plan to adapt the technology so that it can generate more precise white blood cell counts, which would make it useful for monitoring bone marrow transplant recipients or people with certain infectious diseases, Castro - Gonzalez says.

The team could isolate muscle stem cells from the male mice before they died and when they transplanted them into muscle - damaged recipient mice, they found that the stem cells were able to regenerate new muscle.

Even a small number of functioning, insulin - producing cells can restore hypoglycemic awareness, although transplant recipients may need to continue taking insulin to fully regulate blood glucose levels.

They first transplanted undifferentiated iPS cells into the leg muscles of genetically identical recipient mice.

Donor stem cells are transplanted to a recipient, but not without the risk of developing GVHD, a life - threatening complication and major cause of death after SCT.

One is the risk that the transplant recipient might reject the cells, or that the implanted cells might also affect other functions.

Targeting it could be an effective way to improve stem cell transplants for both donors and recipients.

Transplant recipients, on the other hand, may need enhanced Del - 1 interaction to ensure the transplanted cells engraft and begin making new blood cells more rapidly.

While the T cells of the liver transplant recipients reacted to the donor organ cells weakly, their reaction to other antigens was preserved.

The scientists see potential applications in bone marrow and stem cell transplants, for both donors and recipients.

To eliminate the problem for good, Faustman borrowed an idea from the transplant specialists, who have found that liver or spleen cells can «reeducate» a graft recipient's immune system to treat the graft as native tissue.

Researchers need to identify cells — possibly adult stem cells from the patient — that can reconstruct lung tissue without provoking attack by the immune system, the problem that plagues current transplant recipients.

The first off - the - shelf stem cell treatment to gain regulatory approval was launched in Japan last year, and prevents transplanted organs from attacking their recipients.

A team of researchers led by Andreas Beilhack and Harald Wajant of the University Hospital W?rzburg devised an alternative way to prevent GvHD in mice, developing a protein called STAR2 that can stimulate the formation of the transplant recipient's own T reg cells in vivo.

Because donated immune cells recognise the foreign tissue from the transplanted kidney, the thymus gets rid of the recipient's own T - cells that could otherwise attack the kidney.

In patients with GVHD, newly transplanted T cells from the bone marrow graft attack the transplant recipient's body.

Previous attempts to get round this problem have included coating insulin - producing cells in a seaweed derivative prior to transplant to keep them from being attacked by the recipient's immune system.

Ninety - five percent of mice survived transplant and more than 95 % of peripheral blood leukocytes in recipients were donor - derived CD45.1 + cells.

Research Interests: Immunologic memory; memory T - cells; allograft rejection; transplantation; therapies for transplant recipients

Then, they transplanted these cells into recipient mice and confirmed that the cells can form all of the blood cell lineages in vivo.

Indeed, our results indicate that adoptive transfer of CD8 + T cells from CD4 KO mice that had rejected corneal allografts resulted in the rejection of 95 % of the corneal allografts transplanted to athymic recipients.

Because the bioengineered organ was made with her own cells, she won't have to take anti-rejection drugs like regular transplant recipients must do.

One important line of our work has revealed mechanisms how hematopoietic stem cells can generate more myeloid cells to protect transplant recipients from lethal infections.

Adaptive immune cell methylation pattern may be a fingerprint of acute rejection in kidney transplant recipients.

Interestingly, when parental d42m1 sarcoma cells were transplanted into wild - type mice, around 20 % of recipients developed «escape» tumors which evaded immune destruction and progressed (escape clones).

Researchers from the Buck Institute report one of the first demonstrations of long - term vision restoration in blind mice by transplanting photoreceptors derived from human stem cells and blocking the immune response that causes transplanted cells to be rejected by the recipient.

Contact between the donor's and the recipient's immune cells can trigger rejection of the transplanted tissue.

Clinical - scale Rapid Autologous BK - virus Specific T Cell Line generation from Kidney Transplant Recipients with Active Viremia for Adoptive Immunotherapy.

On day 0, recipient mice were transplanted with 5 × 106 T cell — depleted bone marrow (TCD - BM) cells and 1 × 106 spleen T cells from B6 donors.

These transplanted cells fused with neurons and glial cells of the recipient mice.

Indeed, persistent cell division may contribute to the sustained high performance of hNPCctx transplant recipients over time.

The patients» biopsies she sees are mainly from child recipients of oncologic and hematopoietic stem cell transplants.

By typing for HL - A antigens, donors and recipients of white blood cells, platelets, and organs can be «matched» insuring good performance and survival of transfused and transplanted cells.

Treatments are limited — some patients receive transplants of stem cells found in bone marrow from which blood cells develop, but donors are hard to come by and the procedure holds risky complications for recipients.

«In other words, even if the donated stem cells were «foreign,» they did not provoke a harmful immune reaction in the recipient animals, as transplanted tissue normally does.»

If these results are confirmed and one or more of these FLT3 - targeted drugs become approved by the FDA, testing for the FLT3 biomarker may eliminate the need for thousands of patients to undergo stem cell transplantation (each allogeneic transplant costs hundreds of thousands of dollars and place recipients at grave risk of infection and other complications such as Graft vs. Host disease).