Sentences with phrase «cell transplant studies»
A more preliminary study (just 18 patients) using the same approach at Stanford and University of Pittsburgh was published this summer in Stroke, which says it was the «first reported intracerebral stem cell transplant study for stroke in North America.»
http://www.emoryhealthsciblog.com/ Not exact matches
Cadwell cautions that such a strategy must await further evidence to confirm his theory that this trend in Paneth cell death occurs in people deficient in ATG16L1 who are, like his study mice, prone to higher risk of inflammatory disease and transplant rejection.
«Our study results are the first to argue that we may be able to treat inflammatory bowel disease and protect against transplant rejection not only by blocking TNF alpha as is done currently, but also by stimulating ATG16L1 to prevent early death of cells lining the gut,» says study senior investigator Ken Cadwell, PhD, an associate professor at NYU School of Medicine and NYU Langone Health's Skirball Institute for Biomolecular Medicine.
Richard Jones, M.D., professor and director of the Bone Marrow Transplant Program at Johns Hopkins, developed a now commonly used assay to study ALDH levels in individual cells.
The team has already successfully repopulated pig kidneys with human cells, but Ott says further studies are vital to guarantee that the pig components of the organ do not cause rejection when transplanted into humans.
Guo and his collaborators continue their studies by establishing additional mouse models of leukemia that have been transplanted with patient cells of relapsed and refractory disease.
The authors of the study say that improvements in management, multi-drug chemotherapy, immunotherapies, stem cell transplants, radiotherapy and treatments that have less toxic side - effects have all contributed to the improvement in survival from leukemia.
In a separate but related study, scientists this week also announced that they successfully reversed Parkinson - like symptoms in several monkeys by transplanting human neural stem cells into their brains.
Together, the two studies advance the idea that gut microbes play a role in turning the immune system against nerve cells, causing MS.. It will take a lot more work to develop cures or preventive strategies based on that, but the research raises the intriguing possibility of treating an often - devastating disease with something as low - tech as fecal transplants or probiotics.
Mice transplanted with cells grown from a patient suffering from Huntington's disease (HD) develop the clinical features and brain pathology of that patient, suggests a study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers at Université Laval in Québec City, Canada.
«We were able to study the transplant sites in parallel and really look at the pros and cons of each to compare the survival rates of the cells in each area,» said Weaver.
In this study, Cherqui's team transplanted wildtype HSPCs into an FA mouse model, reporting that the HSPCs engrafted and soon differentiated into macrophages in key regions of the mice's brain and spinal cord where they appeared to transfer wildtype FXN into deficient neurons and muscle cells.
He notes that in his study there was evidence of stem cells replacing lost neurons as well as other benefits conferred by the transplant.
In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.
While some previous studies found that maintenance lenalidomide after autologous hematopoietic stem cell transplant improved overall survival for newly diagnosed multiple myeloma patients, others showed no benefit to this approach.
The study, «Lenalidomide (LEN) maintenance (MNTC) after high - dose melphalan and autologous stem cell transplant (ASCT) in multiple myeloma (MM): A meta - analysis (MA) of overall survival (OS),» is ASCO 2016 abstract no. 8001 and will be discussed during the Hematologic Malignancies — Plasma Cell Dyscrasia oral abstract session Friday, Juncell transplant (ASCT) in multiple myeloma (MM): A meta - analysis (MA) of overall survival (OS),» is ASCO 2016 abstract no. 8001 and will be discussed during the Hematologic Malignancies — Plasma Cell Dyscrasia oral abstract session Friday, JunCell Dyscrasia oral abstract session Friday, June 3.
«Lenalidomide maintenance following autologous stem cell transplant can now be considered a standard of care for people with multiple myeloma,» says Dr. McCarthy, senior author on the meta - analysis and Principal Investigator of the U.S. study, CALGB (Alliance) 100104.
The mini-brain lasts about a month and it could be used to study a range of challenges in neuroscience including transplanting nerve cells that could help treat Parkinson's disease and studies on how adult nerve stem cells develop.
Researchers can create iPSCs from a patient's blood or skin cells, and use these patient - specific cells to study diseases or even create new tissues that could be transplanted back into the patient as therapy.
In the current study, almost 80 percent of the patients had undergone a previous stem cell transplant.
For this study, a tumor cell line was transplanted into a rat and imaged with each of the following: conventional MRI, the radiotracer carbon - 13 (C - 13) pyruvate and hyperpolarized MRI at a resolution of 2.5 mm, Medipix positron detector, luminescence sensor and a fluorescence microscope.
Coffin described how lab workers there had transplanted human prostate tumor cells into an immune - deficient lab mouse, a common procedure for procuring a colony of cells, or a human cell line, for further study.
In a new study the PhD students Jan Hoeber, Niclas König and Carl Trolle, working in Dr.Elena Kozlova's research group transplanted human stem cells to an avulsion injury in mice with the aim to restore a functional route for sensory information from peripheral tissues into the spinal cord.
These findings have suggested the development stages at which to transplant cells — for instance, photoreceptor cells need to be relatively more mature than stem cells, according to Thomas Reh, who studies retinal development at the University of Washington.
Unlike transplanted beta cells — or other types of real cells genetically engineered to release insulin for diabetes treatment (SN: 1/15/11, p. 9)-- these artificial cells could be mass - produced and have a much longer shelf life than live cells, says study coauthor Zhen Gu, a biomedical engineer at the University of North Carolina at Chapel Hill.
In recent studies of cancer patients who received a bone marrow transplant, genes from the marrow's white blood cells were found in the patient's tumor cells.
On 1 July, Italian Health Minister Beatrice Lorenzin appointed a scientific committee to coordinate the study, which includes the heads of the Superior Health Institute, the National Italian Transplant Centre, and the Italian Medicines Agency, along with Italian stem cell scientists.
The studies, led by University College London (UCL) laryngologist Martin Birchall, would take donor larynxes or tracheas from donors, «seed» them with a patient's own stem cells, and then transplant them into the patient.
Similarly, feasibility studies conducted by Kean found that abatacept blocks the activation of certain T cells after transplant.
By reinsulating damaged nerves and regenerating nerve cells, Schwann cell transplants have earned their stripes in paralyzed mouse, pig and primate studies over the past decade.
One of the biggest challenges for medical researchers studying the effectiveness of stem cell therapies is that transplants or grafts of cells are often rejected by the hosts.
A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life - threatening complication of stem cell transplants (SCT) used to treat leukemia and other blood disorders, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.
She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.
Now, in a study recently published in the journal PLOS ONE, a team of scientists from VCU Massey Cancer Center have shown a genetic relationship between the reactivation of hCMV and the onset of graft - versus - host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant.
This feature would be critical for clinical uses, such as transplanting stem cells — with their defects corrected — back into patients, but the researchers emphasize that years of further study remain before such treatments might be possible.
«Our results suggest that megakaryocytes might be used clinically to facilitate adult stem cell regeneration and to expand cultured cells for adult stem cell transplants,» says Meng Zhao, Ph.D., a postdoctoral fellow at Stowers and lead author on the study.
«The cells retained their original skills for weeks following the transplant,» says Dr. Sascha Cording, one of the study's first authors.
However, a new study published in Cell Reports provides clues about how the dose of transplanted bone marrow might affect patients undergoing this risky procedure, frequently used to treat cancer and blood diseases.
The research team tested the hypothesis by transplanting cells onto the surface of mouse bone grafts and studying the cell behavior both in vivo — inside the animal — and in vitro — outside the body.
In this study, the researchers also showed that they could grow tumor cells from patients into organoids that could be transplanted into mice.
The study enrolled 61 older adults from the University of Michigan and Washington University in St. Louis who were undergoing a reduced - intensity bone marrow transplant with cells donated from a relative.
In previous studies on liver - cell reprogramming, scientists had difficulty getting stem cell - derived liver cells to survive once being transplanted into existing liver tissue.
Their study, published in the September issue of Experimental Neurology, is believed to be the first to test the helper - cell tactic, which they hope will someday help to overcome a major barrier to successful stem cell transplants.
In the current studies, the researchers used a transplanted colon cancer cell line.
«Tracheobronchial transplantation with a stem - cell - seeded bioartificial nanocomposite: a proof - of - concept study,» which described the first case of a transplant using an artificial trachea seeded with the patient's own stem cells, now bears an expression of concern from The Lancet editors, citing ongoing investigations.
«Experimental orthotopic transplantation of a tissue - engineered oesophagus in rats» describes transplanting an esophagus into rats that was seeded with their own stem cells, and notes that all animals survived the study period (14 days), and gained more weight than rats given a placebo operation.
Previously, studies of stem cell transplants for heart disease have only been performed in patients already scheduled for open heart surgery.
Through the UCSD Clinical Cardiovascular Cell Therapy program, Dib and collaborating cardiology faculty plan to conduct clinical studies in a number of areas, including the effectiveness of adult stem cell transplant as a treatment for congestive heart failure; as a way to minimize heart damage after a heart attack; and in the formation of new blood vessels (angiogenesis) to increase blood flow to the heart for patients experiencing chest pCell Therapy program, Dib and collaborating cardiology faculty plan to conduct clinical studies in a number of areas, including the effectiveness of adult stem cell transplant as a treatment for congestive heart failure; as a way to minimize heart damage after a heart attack; and in the formation of new blood vessels (angiogenesis) to increase blood flow to the heart for patients experiencing chest pcell transplant as a treatment for congestive heart failure; as a way to minimize heart damage after a heart attack; and in the formation of new blood vessels (angiogenesis) to increase blood flow to the heart for patients experiencing chest pain.
Earlier studies suggested this process contributes to the high mortality and low insulin production often displayed in beta cell transplants, which aim to replace cells that the body's own immune system kills off in type 1 diabetes.
«There is some talk of going into 3 - D cell models rather than xenografts, because it is so difficult and challenging to grow [the transplanted tumors],» says Manish Kohli, the Mayo Clinic oncologist leading the PROMOTE study.