Sentences with phrase «cell transplantation for»
While there's growing interest in the use of stem cell transplantation for treating type 2 diabetes, not much research has looked at the use of stem cells derived from bone marrow.
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Duval M, Klein JP, He W, Cahn JY, Cairo M, Camitta BM, Kamble R, Copelan E, de Lima M, Gupta V, Keating A, Lazarus HM, Litzow MR, Marks DI, Maziarz RT, Rizzieri DA, Schiller G, Schultz KR, Tallman MS, Weisdorf D. Hematopoietic stem - cell transplantation for acute leukemia in relapse or primary induction failure.
«We are actively involved in expanding the possible resources for hematopoietic stem cell transplantation for these patients.»
Cuvelier GD, Schultz KR, Davis J, Hirschfeld AF, Junker AK, Tan R, Turvey SE.: Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.
Our Stem Cell Transplant Center is at the forefront of new, improved protocols for stem cell transplantation for blood - related disorders, including CSA.
Hunger SP, Loh KM, Baker KS, Schultz KR.: Controversies of and unique issues in hematopoietic cell transplantation for infant leukemia.
Studies to improve the knowledge of genetic diseases include the natural history study for MLD, advanced diagnosis and natural history of primary immunodeficiencies and immunedysregulatory disorder, and immune reconstitution after hematopoietic stem cell transplantation for genetic disorders.
«I'm a big proponent of islet cell transplantation for type 2 diabetics,» says Dr. Gordon Weir, who is one of the world's foremost experts on islet cell transplantation as Co-Head...
Mehta J, Gordon LI, Tallman MS, et al., Does younger donor age affect the outcome of reduced - intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies beneficially?
Conditional survival and excess mortality after high - dose therapy with autologous stem cell transplantation for adult refractory or relapsed Hodgkin lymphoma in Norway.
A national study on conditional survival, excess mortality and second cancer after high dose therapy with autologous stem cell transplantation for non-Hodgkin lymphoma.
Zhao and his colleagues are also investigating whether a megakaryocyte niche can be used to help expand human hematopoietic stem cells in vitro and stem cell transplantation for patients.
«Stem cell transplantation for multiple myeloma: New data did not change conclusion.»
Not exact matches
Previously, Dr. Nikolic was an Assistant Professor in Medicine at Harvard Medical School where he led an advanced immunology laboratory for tolerance induction and stem - cell transplantation at Massachusetts General Hospital / Harvard Medical School.
Duly reverential, the panel satisfied itself with simply listing all the research possibilities, including the improvement and increased safety of IVF, the creation of cell lines that might someday be useful for bone marrow transplantation, repair of spinal cord injuries, skin replacement and, naturally, the hint of a greater understanding of cancer.»
It is possible that spider silk could also be used in future for other neurological diseases where cell transplantation plays a role.
Stem cells in babies» urine seem to help regenerate kidney tissue, protecting it from toxic drugs and could pep up organs for transplantation
The work raises hope that the cells, known as «induced pluripotent stem cells» or iPS cells, can be made safe for transplantation into people.
An update search enlarged the pool of study data, but did not change the content of the conclusion of the benefit assessment of stem cell transplantation (SCT) for multiple myeloma conducted in 2012.
To have enough cells for transplantation, they must be grown in vitro and prevented from differentiating before transplantation.
«Due to the inhibitory function of Treg cells, people have been trying to use these cells for therapy in human autoimmune diseases or transplantation,» explains professor Yun Cai Liu, Ph.D., who led the current study.
Still, Scholl adds, transplantation of RPE cells «can't be it» for such patients, because ultimately they need new photoreceptors to restore vision.
In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.
Alasdair Rankin, director of research at charity Diabetes UK, says that improving the number and viability of cells for transplantation is a major focus of research here and around the world.
UTSW co-authors include: Co-lead author Maria Winter, a research associate; Dr. Luisella Spiga, a postdoctoral researcher; visiting fellow Lisa Büttner; graduate students Elizabeth Hughes and Caroline Gillis, all of Microbiology; Dr. Breck Duerkop, Instructor, Immunology; Cassie Behrendt, a research technician, Immunology; Dr. Lora Hooper, Professor and Chair of Immunology with appointments in Microbiology and in the Center for the Genetics of Host Defense, a HHMI Investigator and holder of the Jonathan W. Uhr, M.D. Distinguished Chair in Immunology, and the Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell; Dr. Luis Sifuentes - Dominguez, Instructor of Pediatrics; Dr. Kayci Huff - Hardy, clinical fellow, Internal Medicine in the Division of Digestive and Liver Diseases; Dr. Andrew Koh, Associate Professor of Pediatrics and Microbiology and in the Harold C. Simmons Comprehensive Cancer Center as well as Director of Pediatric Hematopoietic Stem Cell Transplantation at Children's Health; and Dr. Ezra Burstein, Professor of Internal Medicine and Molecular Biology and Chief of the Division of Digestive and Liver Diseases.
The JDF Center for Islet Cell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatCell Transplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of tTransplantation will fund 32 researchers to focus on four main goals: Reversing the overactive immune response that kills islet cells; finding new sources for islet cell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantatcell transplants, such as pigs or genetically engineered cells; persuading the body to accept the transplanted cells without immunosuppressive drugs that often trigger worse side effects than the disease; and overcoming the technical difficulties of transplantationtransplantation.
«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.
These findings have significant implications for both human stem cell transplantation and for radiation exposure.
Autologous hematopoietic stem cell transplantation (AHSCT) has been investigated as a treatment for aggressive MS, the rationale for which is immune reconstitution.
The capsule creates the biotechnical condition for it, because it separates the donator's cells from the body of the receiver and transfers the hormones which are important for the metabolism exclusively «In the eyes of Dresden scientists this kind of transplantation will be suitable for patients with adrenal insufficiency but also with congenital diseases such as the lack of 21 - hydroxylase.
Cell transplantation as a treatment for diabetes is still essentially experimental, uses cells from cadavers, requires the use of powerful immunosuppressive drugs, and has been available to only a very small number of patients.
Unlike the undifferentiated iPS cells, though, both the iPS - derived endothelial cells and the aortic endothelial cells survived for at least 63 days after transplantation.
HSCT is effectively used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.
Hematopoietic stem cell transplantation (HSCT), once considered an effective yet risky alternative to drug therapy for blood cancer, has become more accessible and successful in a wide range of patients as a result of major advances in transplant strategies and technologies.
Dr. Cooper joined MDACC in 2006 as section chief of cell therapy at the Children's Cancer Hospital, where he cared for children undergoing bone marrow transplantation and led scientific efforts to develop new treatment approaches that pair genetic engineering with immunotherapies.
In the event that it becomes possible to generate large numbers of specialized cells for transplantation, such a facility would aim to find reasonable tissue matches for patients so that rejection can be tackled using conventional immunosuppressives.
Organ transplantation is a challenge, requiring immunosuppressive drugs and careful matching of donor and recipient for human leukocyte antigen markers, receptors on immune cells that recognize foreign proteins.
The research, the team said, should not discourage the pursuit of experimental treatments but instead be heeded as a call to screen rigorously all cell lines for mutations at various stages of development as well as immediately before transplantation.
In the study, analysis of patient samples demonstrated that high LSC17 scores meant poor outcomes with current standard treatment, even for patients who had undergone allogeneic stem cell transplantation.
«Our work not only holds potential for developing cells for treatment of other areas of the eye, but could set the stage for future human clinical trials of anterior eye transplantation to restore visual function.»
«Multiple myeloma patient study shows promise for natural killer cells: Phase I study included combination with high - dose chemotherapy and stem cell transplantation.»
«Protection for the gut barrier: New approach may prevent graft - versus - host disease: Activating signal paths could protect patients from dangerous immune reactions after stem cell transplantations.»
Shah and Shpall's team enrolled symptomatic patients who qualified as candidates for high - dose chemotherapy drugs like melphalan, and transplantation of the patient's own stem cells.
Umbilical cord blood, for example, generally contains insufficient numbers of stem cells for it to be used as a source of HSCs for transplantation into adult patients.
This could be helpful for increasing donor cell numbers for transplantation.
In this way we hope to lay a clinical groundwork for two new techniques: liver cell transplantation and liver gene therapy.»
Scientists have suggested that such embryonic stem cells could be used for learning about genetic diseases, testing new drugs on cells grown in the lab, or growing healthy cells for therapeutic transplantation.
«But, based on our data, we believe there is a case for early intervention with personalized antiviral treatments following stem cell transplantation in order to suppress hCMV reactivation.»
An artificial bioreactor may in future supply limitless quantities of blood and bone marrow cells for transplantation into people with leukaemia and other blood diseases.
One promising way to treat diseased or damaged kidneys is cell therapies that include the transplantation of renal progenitor cells, which can then develop into the cells needed for full recovery.