Sentences with phrase «cell transplantation from»

Learn more about bone marrow and peripheral blood cell transplantation from the U.S. National Cancer Institute.

Low - Dose ATLG Prevents GVHD in Pediatric Hematologic Malignancies: A newly published randomized phase III study of pediatric patients showed lower doses of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation from an unrelated donor.

Not exact matches

The difficulties associated with obtaining nerve tissue at the correct stage of development and differentiation from aborted embryos means that foetal tissue transplantation is no longer in favour, but the creation of human embryos specifically as sources of stem cells, and the push to use «spare» embryos from IVF treatments is gatheringmomentum.

Both involve a technique called nuclear transplantation — replacing the nucleus of a donor's egg with the DNA from an adult cell.

Stem cells in babies» urine seem to help regenerate kidney tissue, protecting it from toxic drugs and could pep up organs for transplantation

But because yeast does not contain restriction - modification systems, such transplantation poses problems not encountered in transplantation from one bacterial cell to another.

To have enough cells for transplantation, they must be grown in vitro and prevented from differentiating before transplantation.

The researchers have now reported in the journal Nature that the normal process of blood formation differs from what scientists had previously assumed when using data from stem cell transplantations.

Tufts Medical Center and Tufts University scientists have found exciting, new functions of the protein angiogenin (ANG) that play a significant role in the regulation of blood cell formation, important in bone marrow transplantation and recovery from radiation - induced bone marrow failure.

The capsule creates the biotechnical condition for it, because it separates the donator's cells from the body of the receiver and transfers the hormones which are important for the metabolism exclusively «In the eyes of Dresden scientists this kind of transplantation will be suitable for patients with adrenal insufficiency but also with congenital diseases such as the lack of 21 - hydroxylase.

«The concept of exosome therapy is interesting because it could potentially shift our strategy from living - cell transplantation to the use of a non-living agent,» he added.

Cell transplantation as a treatment for diabetes is still essentially experimental, uses cells from cadavers, requires the use of powerful immunosuppressive drugs, and has been available to only a very small number of patients.

Trapnell and Suzuki were prompted to test the novel macrophage transplantation therapy by studies showing that resident macrophage populations (such as those residing in the lung) can self - maintain without the cells having to regenerate directly from the bone marrow.

From the first day of transplantation, the cells produced insulin in response to glucose spikes in the mice's blood, alleviating the modeled diabetes.

HSCT is effectively used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.

These cells that result from genome transplantation are phenotypically identical to the M. mycoides LC donor strain as judged by several criteria.

Areas covered range from basic studies into the biology of innate and adaptive immunity (immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology) to immune contributions to health and disease (host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency).

However, Eggan and McCarroll emphasized that now that this phenomenon has been found, inexpensive gene - sequencing tests will allow researchers to identify and remove from the production line cell cultures with concerning mutations that might prove dangerous after transplantation.

«Protection for the gut barrier: New approach may prevent graft - versus - host disease: Activating signal paths could protect patients from dangerous immune reactions after stem cell transplantations.»

The technology to grow NK cells from umbilical cord blood was developed by Nina Shah, M.D., assistant professor and Elizabeth J. Shpall, M.D., professor in the department of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center.

The researchers then assessed the prevalence of a kind of immune cell called a myeloid cell, which were derived from the donated stem cells in the blood of the recipient mice, at eight and 16 weeks after transplantation.

We report the design, synthesis, and assembly of the 1.08 — mega — base pair Mycoplasma mycoides JCVI - syn 1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only by the synthetic chromosome.

Months to years after transplantation, retinal cells derived from human embryonic stem cells appear healthy — and may have unexpectedly helped vision in some recipients

Pretreating mice with STAR2 protected them from developing GvHD after immune cell transplantation.

In their report published in Cancer Immunology Research, a team from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH) describes how adding AMD3100 (plerixafor)-- previously approved for the stimulation of stem cell production prior to bone marrow transplantation — to their investigational drug VIC - 008 more than doubled the animals» survival time.

Won Soon Park, MD, PhD, and colleagues from Samsung Medical Center and Biomedical Research Institute, Seoul, Republic of Korea, conducted a phase I, single - center trial of intratracheal transplantation of human umbilical cord blood - derived mesenchymal stem cells to nine very preterm infants (24 - 26 weeks gestational age) who were at high risk of developing BPD.

«Tracheobronchial transplantation with a stem - cell - seeded bioartificial nanocomposite: a proof - of - concept study,» which described the first case of a transplant using an artificial trachea seeded with the patient's own stem cells, now bears an expression of concern from The Lancet editors, citing ongoing investigations.

Review of «Tumor - Free Transplantation of Patient - Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration» from Stem Cells Translational Medicine by Stuart P. Atkinson

Now, in a study published in Stem Cells, the Ahmad group report on the creation of RGCs from adult corneal limbal cells using this methodology, and demonstrate iPSC - derived RGCs to be functional and safe in transplantation experimentsCells, the Ahmad group report on the creation of RGCs from adult corneal limbal cells using this methodology, and demonstrate iPSC - derived RGCs to be functional and safe in transplantation experimentscells using this methodology, and demonstrate iPSC - derived RGCs to be functional and safe in transplantation experiments [3].

They acknowledge modest benefit from hematopoietic stem cell transplantation in cardiac disease and ameliorative but noncurative outcomes in autoimmune diseases.

Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.

Researchers from the group of Gary L. Dunbar at Central Michigan University, Michigan, USA have recently shown the ability of adenovirally generated rat iPSCs to survive and differentiate in the striatum of rats [6], and now in a study in Stem Cells Translational Medicine, they focus on the efficacy of transplantation of these cells into the 3 - nitropropionic acid (3 - NP) rat model of HD [7], which induces cell death by energy - depleting mechanisms providing an accurate model of cell loss and replicates many features of the diseaseCells Translational Medicine, they focus on the efficacy of transplantation of these cells into the 3 - nitropropionic acid (3 - NP) rat model of HD [7], which induces cell death by energy - depleting mechanisms providing an accurate model of cell loss and replicates many features of the diseasecells into the 3 - nitropropionic acid (3 - NP) rat model of HD [7], which induces cell death by energy - depleting mechanisms providing an accurate model of cell loss and replicates many features of the disease [8].

Review of «Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.

Stem cell transplantation in general, using donor cells from either bone marrow, mobilized blood, or cord blood has become a more common practice over the last twenty years.

Writing in the Transplantation, the researchers from Johns Hopkins Medical Institutions warned clinical use of stem cells was still a long way off.

Pluripotent stem cells, from a slightly later stage, can give rise to any specific tissue, but they fail to support more fundamental development such as growing organs for transplantation or building new mouse models.

We have also generated T - regs (CD4 + / 25high / 127low / --RRB- in vitro from donor AD - MSC and recipient peripheral blood mononuclear cells and these T - regs are infused in thymus of renal allograft recipients after kidney transplantation.

Led by our faculty team of 25 physicians and scientists, our patients benefit from a team approach that includes our colleagues in radiology, surgery, radiation therapy, hematopathology, and stem cell transplantation, as well as clinical pharmacists, research and clinical nurses, social workers, and dietitians.

He moved to the Scripps Clinic and Research Foundation in La Jolla, USA from 1975 to 1979, where he studied T cell maturation and development of the T cell repertoire, dependent on the transplantation antigen expression in the thymus.

In the future, outpatient blood and bone marrow stem cell transplantation will be offered to a broader group of patients with other blood disorders and for allogeneic transplants (transplant from non-twin donor stem cells).

Use of a lower dose of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose in children with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT) from an unrelated donor, according to the results of a study published in Lancet Oncology.

Dr. Maharaj obtained his medical degree from the University of Glasgow Medical School, Scotland and completed his internship and residency in Internal Medicine and Hematology followed by specialist fellowship training in Hematology, Oncology and Bone Marrow Stem Cell Transplantation at the University's Glasgow Royal Infirmary, Scotland.

Lanza and his colleagues were also the first to demonstrate that nuclear transplantation could be used to reverse the aging process and to generate immune - compatible tissues, including the first organ tissue - engineered from cloned cells.

Investigators, clinicians, laboratory technicians, clinical research professionals, nurses, pharmacists, administrators, and allied health professional attendees benefit from the full scientific program that addresses the most timely issues in hematopoietic cell transplantation.

Allogeneic cell transplantation enables the use of «younger» cells, from fetal origins (e.g., umbilical cord blood, placenta) or healthy donors, which are considered to be effective due to higher regenerative potential and plasticity.

These results, published today (December 12) in Nature Biotechnology, have implications for autologous transplantation — creating a replacement tissue from a patient's own cells — something that older people are more likely to need, the authors noted.

I hope in the next year we'll be able to develop and report on a method that allows the creation of billions of human beta cells that can then be used in two contexts; one, for transplantation into diabetics, and the other; using iPS cells from patients, for drug screening..

Role of hematopoietic stem cells in steady state hematopoiesis It is remain not very clear if all blood cell types are developed from one hematopoietic stem cell (HSC) in normal hematopoiesis, because of limitations of conventional transplantation models.

And adult stem cells have saved the lives of over 1 million people worldwide through transplantations, but not one person is alive today because of stem cells from aborted fetal tissue.

Review of «Biological markers of Mesenchymal Stromal Cells as Predictors of response to Autologous Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis; an Investigator - Initiated Trial and in Vivo Study» from Stem Cells by Stuart P. Atkinson