Sentences with phrase «cell transplants from»

«Long - term remissions in some patients after stem cell transplants from donors have been observed, but treatment - related toxicity limits the widespread use of this therapy.»

They are safer than cells transplanted from a donor because risk of rejection is gone.

Researchers report today that they grew prostate glands — important for reproduction in male mammals — in mice using a single stem cell transplanted from the prostates of donor mice.

One year later Brown's cancer returned, and he was given another stem cell transplant from the same donor.

The only curative treatment is a hematopoietic (blood - forming) stem cell transplant from a compatible donor.

Results from a recent trial of this technique in a SCID disorder show 100 % survival rates at 7 years post-treatment, xvi compared with 85 % survival in patients receiving a stem cell transplant from a healthy sibling.

Not exact matches

The cost of stem cell transplants, for example, range from $ 350,000 to $ 800,000.

«Scientists say they have replaced a 65 - year - old patient's upper jaw with a bone transplant cultivated from stem cells isolated from his own fatty tissue and grown inside his abdomen.»

This may entail making small holes in the bone to allow new cartilage to grow (microfracture), taking cartilage from another part of the athlete's knee and transplanting it into the defect (osteochondral autograft transfer), taking cartilage cells from the knee and then having them grown in a lab for later re-implantation (autologous chondrocyte implantation), or taking cartilage from a person who has passed away and placing it in the defect (osteochondral allograft transfer).

Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

Not only were there no adverse effects from the transplanted cells — this was primarily a safety trial — but 10 patients showed marked improvements in vision, and the eyesight in another seven seems to have stabilized.

Da Cruz and his team grew replacement RPE cells from human embryonic stem cells on a thin plastic scaffold, before transplanting the tissue into the back of each volunteer's eye.

In somatic cell nuclear transfer, a nucleus from a mature body cell is transplanted into an egg cell without a nucleus.

A woman with age - related macular degeneration seems to have had her vision stabilised thanks to a transplant of retinal cells generated from her skin

For example, a consortium of research groups called the London Project to Cure Blindness aims to test RPE transplants from embryonic stem cells in patients with macular degeneration this year.

A drug used to stop immune cells from gobbling up transplanted organs and bone marrow has been caught boosting the immune response to a virus in mice and monkeys.

Craig Venter «s team at the J. Craig Venter Institute in Rockville, Maryland, and San Diego, California, has made a bacterial genome from smaller DNA subunits and then transplanted the whole thing into another cell.

Previous researchers have also used cell transplant technologies to repair injured hearts, but these used CMs organized in two dimensions with a random, myofibril structure, which is different from natural heart tissue.

The Boston patients, in contrast, are free of the virus thanks to a combination of a bone marrow transplant plus continuing antiretroviral drugs to stop newly donated immune cells from being infected.

They both had standard chemotherapy to kill their native blood cells before undergoing a bone - marrow transplant from a donor to repopulate their blood.

The authors of the study say that improvements in management, multi-drug chemotherapy, immunotherapies, stem cell transplants, radiotherapy and treatments that have less toxic side - effects have all contributed to the improvement in survival from leukemia.

Stem cells created from unfertilized mice eggs are successfully transplanted without immune rejection

Jacob's team has transplanted the back - up or «alternative» respiratory machinery from the mitochondria of lower organisms to human cells, showing that it can protect against pathological stresses, and even lethal poisons like cyanide, that target the mitochondria.

However, to be truly useful, one must be able to transplant the bacterial chromosome from yeast back into a recipient bacterial cell.

Freed expects transplants of neurons derived from embryonic stem cells to enter the clinical arena soon as well.

Patients with severe and end - stage heart failure have few treatment options available to them apart from transplants and «miraculous» stem cell therapy.

Mice transplanted with cells grown from a patient suffering from Huntington's disease (HD) develop the clinical features and brain pathology of that patient, suggests a study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers at Université Laval in Québec City, Canada.

Two men known only as the «Boston patients» have both stopped taking their anti-HIV medications following transplants of bone - marrow stem cells that appear to have banished the virus from their bodies.

And early stage startup Neochromosome, which includes Boeke, intends to raise money to design synthetic chromosomes for medicine that could be used in an off - the - shelf universal cell line in cell therapies and transplants with minimal risk of rejection from the immune system.

Eighteen adults with severe eye disease who were among the first people to receive transplants created from human embryonic stem cells (hESCs) continue to have no apparent complications with the introduced cells after an average of nearly 2 years, according to the latest status report on their health.

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

In people with severe eye disease, transplants made from embryonic stem cells (in region of black dotted circle) appear safe, and became larger and more pigmented over time (right).

Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.

Rather, the group speculates that the transplanted cells secreted protective neurotrophins, proteins that promote cell survival by keeping neurons from inducing apoptosis (programmed cell death).

«If you give patients immune cells to eradicate any remaining cancer cells that might be present,» he says, «those immune cells would not be prevented from doing their job by ongoing immune suppression drugs that are being used in patients treated with conventional transplant approaches.»

Once the UCLA researchers had produced iPS cells that were free from Duchenne mutations, they differentiated the iPS cells into cardiac muscle and skeletal muscle cells and then transplanted the skeletal muscle cells into mice that had a genetic mutation in the dystrophin gene.

The cells were derived from eggs that had been injected with DNA from the patients, so they could eventually be transplanted back to replace or correct the patient's diseased cells without fear of immune rejection.

After fishing stem cells from each individual's own blood, the researchers inserted a normal version of the ABCD1 gene into some of the cells and transplanted them back into the kids.

Because of this, families and doctors often shrink from transplant options, particularly when it comes to treating children, and it will limit the extent to which the breakthroughs in gene therapy and gene editing will be applied, explained Scadden, who is a practicing hematologist at MGH and chairman of Harvard's Department of Stem Cell and Regenerative Biology.

Diabetes researchers are considering various replacements for insulin injections: Transplanting new pancreatic islet cells that make insulin, coaxing the patient's own islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from destroying the rest of their pancreatic islets.

Now, six years after insulin - producing cells were first transplanted into people with diabetes, results from the largest trial yet of the «Edmonton protocol» are in.

By measuring the signal returned from the transplant locations, she was able to determine how many of the cells survived.

Beta cells donated from deceased individuals have already been transplanted into diabetic patients through a procedure called the Edmonton protocol.

«When we transplanted our labeled blood stem cells from the bone marrow into other mice, only a few stem cells were active in the recipients, and many stem cells were lost,» Rodewald explains.

Beyond this, we could take the DNA repair abilities from Polypedilum vanderplanki, a fly whose larvae can survive complete desiccation and extremes of heat and cold, and transplant them into human cells.

Researchers can create iPSCs from a patient's blood or skin cells, and use these patient - specific cells to study diseases or even create new tissues that could be transplanted back into the patient as therapy.

Others include transplanting so - called Schwann cells from peripheral nerves, using growth factors to stimulate nerve growth, and boosting the immune system in the damaged area (New Scientist magazine, 14 August 1999, p 36).

Researchers already envision transplanting ready - made embryonic stem cells back into people, providing cures for a huge range of diseases, from diabetes to paralysis to Alzheimer's.

However, in the wake of fatalities from gene therapy and other technologies, as well as the potential for cancers associated with stem cell transplants, governments are understandably nervous about safety issues — not to mention the ethical maze of tinkering with fledgling life.