Sentences with phrase «cell transplants said»
The first patients to receive human embryonic stem cell transplants say their lives have been transformed by the experimental procedure
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«Scientists say they have replaced a 65 - year - old patient's upper jaw with a bone transplant cultivated from stem cells isolated from his own fatty tissue and grown inside his abdomen.»
«Our study results are the first to argue that we may be able to treat inflammatory bowel disease and protect against transplant rejection not only by blocking TNF alpha as is done currently, but also by stimulating ATG16L1 to prevent early death of cells lining the gut,» says study senior investigator Ken Cadwell, PhD, an associate professor at NYU School of Medicine and NYU Langone Health's Skirball Institute for Biomolecular Medicine.
Although drugs are available to replace thyroid function, with this new discovery, «we can now envision that thyroid function could be restored by transplanting patients» own thyroid cells,» said Hollenberg and Kotton.
The team has already successfully repopulated pig kidneys with human cells, but Ott says further studies are vital to guarantee that the pig components of the organ do not cause rejection when transplanted into humans.
«Using these new cells we might achieve organ acceptance in liver transplants, without touching the remaining immune system,» says co-author Luis Graca.
Their next experiment, Coles says, is to transplant the cells into mice with degenerating retinas to see if they restore function and later to figure out how to activate and manipulate them.
«Finding the optimal conditions to avoid interfering with immune cells working to eradicate cancer while preventing graft rejection and GVHD is the holy grail of bone marrow transplant,» says Leo Luznik, M.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center.
The authors of the study say that improvements in management, multi-drug chemotherapy, immunotherapies, stem cell transplants, radiotherapy and treatments that have less toxic side - effects have all contributed to the improvement in survival from leukemia.
On average the transplanted stem cells regenerated 40 percent of the damaged heart tissue, said Dr. Michael Laflamme, UW assistant professor of pathology, whose team was principally responsible for generating the replacement heart muscle cells.
U.S. biotechnology company Circe Biomedical has had similar success, she said, showing in an ongoing clinical trial of a similar device using pig liver cells that six out of 36 patients have completely recovered without the need for transplant.
Although such harvested cells could be cultured as say, liver cells for treating hepatitis or dopamine - producing cells for Parkinson's, the resulting transplants would likely be rejected by patients» immune systems.
«If you give patients immune cells to eradicate any remaining cancer cells that might be present,» he says, «those immune cells would not be prevented from doing their job by ongoing immune suppression drugs that are being used in patients treated with conventional transplant approaches.»
«We were able to study the transplant sites in parallel and really look at the pros and cons of each to compare the survival rates of the cells in each area,» said Weaver.
Scholl is upbeat that the transplanted cells still appear safe and says that analysis of the cells in the recipients» eyes are «indeed an indication that something is happening.»
«This treatment is a new form of cell transplantation that utilizes the patient's own cells, so it does not require immunosuppressive drugs and, thus, avoids the side effects of those drugs,» says Scott Nyberg, M.D., Ph.D., a liver transplant surgeon at Mayo Clinic.
Dr Matthew Hobbs, Head of Research for Diabetes UK, said: «We know that preserving or restoring even relatively small levels of insulin secretion in Type 1 diabetes can prevent hypoglycaemia (low glucose levels) and reduce complications and therefore much research has focused on ways to make new cells that can be transplanted into the body.
«We transplanted about 6 million cells,» says Cecilia Götherström of Karolinska, who produced the cells.
«Lenalidomide maintenance following autologous stem cell transplant can now be considered a standard of care for people with multiple myeloma,» says Dr. McCarthy, senior author on the meta - analysis and Principal Investigator of the U.S. study, CALGB (Alliance) 100104.
The results show that germline stem cells can indeed restore fertility when transplanted into other mice, Wu says.
They also plan to adapt the technology so that it can generate more precise white blood cell counts, which would make it useful for monitoring bone marrow transplant recipients or people with certain infectious diseases, Castro - Gonzalez says.
«Just one transplant of the human EPO - producing cells treated kidney anaemia in mice, keeping their haemoglobin levels in the normal range for the remaining 7 - month lifespan of the animals,» says Kenji Osafune, of Kyoto University in Japan, who led the team.
«We learned a lot with this animal model, but perhaps the most important finding was what we observed when we transplanted skeletal muscle stem cells,» said Kyba.
Dr. Qu said not only did disc height increase, but stem cell transplant also increased disc water content and improved appropriate gene expression.
«This is such a prevalent virus... about 25 percent of stem cell transplant patients get infected [with rhinovirus] during the first year,» said Boeckh, who heads Fred Hutch's Infectious Disease Sciences Program.
Just what triggers the cells surrounding a zebra fish's injury to start dedifferentiating is unknown, but Keating says regenerative therapy for human beings will in some circumstances involve transplanting stem cells to the injured area.
Unlike transplanted beta cells — or other types of real cells genetically engineered to release insulin for diabetes treatment (SN: 1/15/11, p. 9)-- these artificial cells could be mass - produced and have a much longer shelf life than live cells, says study coauthor Zhen Gu, a biomedical engineer at the University of North Carolina at Chapel Hill.
Most cells from a foreign donor, such as in transplanted organs, are targeted by the immune system, but «this one has found a way to suppress the immune system of its hosts long enough to let it be passed along,» he says.
About 10 percent of the more than 26 million Americans living with type 2 diabetes are also dependent upon insulin injections, and would presumably be candidates for beta cell transplants, Melton said.
They're not developed enough to function as liver transplants, but the cell clusters do have important uses, says McGuckin.
Experience with lymphoma patients, who receive a transplant of their own blood or bone cells after radiation to wipe out their cancer, has shown «there's no doubt it helps,» says bone marrow transplant expert Nelson Chao of Duke University in Durham, North Carolina.
«Preventing graft - versus - host disease and relapse after transplant requires a difficult balance of eliminating the bad, overactive effector T cells, without suppressing the good, regulatory T cells,» said Kean, who is also an associate professor of pediatrics at the University of Washington School of Medicine and a member of the Fred Hutchinson Cancer Research Center.
«This opens up bone - marrow transplants to virtually any patient out there with a haematological condition» such as leukaemia or sickle - cell anaemia, says John Tisdale, a haematologist at the US National Heart, Lung and Blood Institute in Bethesda, Maryland.
«Given the serious threat of graft - versus - host disease, new approaches to make stem cell transplants safer for patients remain a critical unmet need,» said Dr. Leslie Kean, the trial's principal investigator and associate director of the Ben Towne Center for Childhood Cancer Research at Seattle Children's.
But a stem cell transplant would help only a worker who received a certain dose — between roughly 5 grays and 10 grays of radiation, Chao says.
One uses primary hepatocytes obtained from livers donated for transplant; the second uses stem cells derived from human skin samples and guided into hepatocyte - like cells, Bhatia says.
Nayernia says it's possible that transplanting his immature sperm cells into human testes could make them functional — but he's awaiting permission for that experiment from his institute's ethics board.
«Because of relatively low survival rates and their advancing age, these patients tend to be poor candidates for aggressive therapies, like a bone marrow transplant,» said senior author Catriona Jamieson, MD, PhD, professor of medicine, chief of the Division of Regenerative Medicine at UC San Diego School of Medicine and director of the Stem Cell Research Program at Moores Cancer Center.
«We were very encouraged to see that the transplanted cells sprouted long distances in both directions — a key characteristic of V2a interneurons — and that they started to connect with the relevant host neurons,» said co-author Dylan McCreedy, PhD, a postdoctoral scholar at Gladstone.
The researchers say their next step is to transplant the cells into mice with spinal cord injuries to see if the V2a interneurons can help to restore movement after damage has occurred.
«In mice, memory T cells are critical for a lung transplant to have a good outcome,» said co-corresponding author Daniel Kreisel, MD, PhD, a Washington University lung transplant surgeon at Barnes - Jewish Hospital.
In a 2015 report, they said that although the approach had no impact on acute GVHD in 35 patients who received peripheral blood stem cell transplants, it sharply reduced the risk of the disease's chronic form.
«Our results suggest that megakaryocytes might be used clinically to facilitate adult stem cell regeneration and to expand cultured cells for adult stem cell transplants,» says Meng Zhao, Ph.D., a postdoctoral fellow at Stowers and lead author on the study.
Acute GVHD is «entirely a T cell — mediated disease, most people would agree,» says Paul Martin, an oncologist and transplant veteran at the Fred Hutchinson Cancer Research Center (the Hutch) in Seattle, Washington.
«The cells retained their original skills for weeks following the transplant,» says Dr. Sascha Cording, one of the study's first authors.
«Umbilical cord blood contains an enriched population of bone marrow stem cells,» says Daniel Weisdorf, director of the Adult Blood and Marrow Transplant Program at the university.
«The dose of transplanted bone marrow has strong and lasting effects on how HSCs specialize and coordinate their behavior,» said Rong Lu, senior author and assistant professor of stem cell biology and regenerative medicine.
Hyperlipidemia also affects regulatory T cells and disrupts their ability to prevent transplant rejection,» said co-first author, Jessamyn Bagley, Ph.D., assistant professor of medicine at TUSM and member of Iacomini's laboratory.
If so, it may be possible to improve transplant outcomes by altering diets and developing therapies that target the specific cells altered by this condition,» said Iacomini.
«Our major CIRM - funded programs, aimed at engineering young stem cell - derived astrocytes to secrete GDNF, then transplanting those cells back into patients, take on even greater importance, given this aging phenomenon,» said Svendsen, the Kerry and Simone Vickar Family Foundation Distinguished Chair in Regenerative Medicine.