Sentences with phrase «cell tumors although»

Not exact matches

Generally scientists have thought autophagy protects against cancer, although some evidence suggests it can help tumor cells cope with nutrient scarcity and other stresses.

Although proteasome inhibitors are very efficient in selective killing of cancer tumor cells grown in a dish (in - vitro), their success in the clinic has largely been undermined by the development of resistance — mechanisms of which are poorly understood.

Although changes in treatment methodology still have to be studied, Dr. Cripe believes it may be that the timing of various treatments is what matters, and that perhaps initially suppressing immunity could allow the virus to infect a large number of tumor cells before relieving the immunosuppression to allow the body's own T cells to fight off the tumor.

Although the link to brain tumors remains inconclusive, the new work suggests cell phones may indeed be messing with our minds.

Although the most common causes are infection (bacterial, viral, fungal or parasitic), chemical agents and even tumor cells may cause meningitis.

But although most patients» tumors initially shrank, the reintroduced T cells eventually became less effective and stopped proliferating.

Although other tumor suppressors exist, what makes Par - 4 so special is that it is not mutated as frequently as other known suppressors, and it's «selective» in its actions in that Par - 4 will only kill cancer cells and not normal cells.

Although telomerase could somehow slow aging, it is also found in most tumor cells, where it aids the uncontrolled growth that characterizes cancer.

«It pointed us to the idea that although T cells and natural killer cells are important, maybe we're forgetting about a part of the immune system that is also really important and could help us achieve our goals of ultimately curing the tumors.»

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

«Although both anti-CTLA-4 and anti-PD-1 improved tumor rejection, mice treated with anti-CTLA-4 exhibited superior tumor control, suggesting the memory T - cell response by this agent is more durable,» said Allison.

Although there is new data coming from Dr. Michel Sadelain's lab and others where they have made a molecule that may work as a CAR T cell that would then bind to NY - ESO - 1 peptides displayed on the surface of a tumor cell.

Although it did not eradicate CML cells, it did greatly limit the growth of the tumor clone and decreased the risk of the feared «blast crisis».

Although scientists have examined insulin action in tumors for years, the ability to knock out the insulin receptor in specific types of tumor cells adds a level of sophistication to these investigations, Rask - Madsen emphasizes.

Similarly, antigen - specific CD4 + CD25 + regulatory T cells also suppress tumor - specific CD8 T cell cytotoxicity although this mechanism relies on TGF - β secretion by regulatory cells 196, 197.

Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers.

Although mutations to the complex, dubbed GATOR1, are prevalent in cancer cells and promote tumor growth, they also render the cells susceptible to treatment with the drug rapamycin.

Although CSCs make up only a small fraction of a tumor, they possess the unique capability to regenerate a tumor whereas most tumor cells lack this regenerative capability [11, 12].

Total 4E - BP1 and p - 4E - BP1 was predominantly cytoplasmic, although additional nuclear localization was seen in a small subset of tumor cells.

Vaccines that aim to expand tumor - specific CD8 (+) T cells have yielded disappointing results in cancer patients although they showed efficacy in transplantable tumor mouse models.

So, although treatment with antifolates affects both tumor cells and non-tumor cells, it has more of an effect on these highly active tumor cells.

Although progress toward harnessing the immune system to attack tumors has been «enormous,» he said, his lab and many others are seeing in more and more studies — in lab mice as well as patients — that «immuno - oncology» will not be as simple as stimulating T cells to attack tumors.

Although we believe our approaches have broad potential across multiple therapeutic areas, we are focused in oncology and have engineered our technologies to activate the immune system's natural ability to create tumor - specific cytotoxic T cells, or CTLs, to fight cancer.

Excitingly, a single dose of any of the three NK cell populations assessed led to a significant reduction in tumor burden, although the iPSC ‐ derived NK group demonstrating a trend toward overall better activity.

Although cancer stem cells have been identified in many different types of cancer, it is becoming increasingly clear that the properties of these cells may vary greatly among the different tumor types.

Although investigators have not yet identified which cells carry Sema4a in tumors and boost regulatory T cell function, the scientists did report that immune cells called plasmacytoid dendritic cells (pDCs) provided more than half of the Sema4a in tumors in this study.

Although this possibility has not yet attracted as much attention as the ideas of cell replacement, personalized medicine and other more direct clinical applications, hESCs are expected to be superior to most commonly used cell - culture models of drug discovery which employ tumor - derived or immortalized cell lines or primary cell culture.

Although some tumors may be formed by initiating cells that do not resemble stem cells, it is likely that stem cell — like tumor cells are more aggressive at forming tumors, with a higher likelihood of relapse and metastasis.

Although the differing effects of hypoxia reported here are in conflict with previously published data, where no contrasting effect was seen (18 — 20), our data was produced using 13 primary breast cancer samples, as well as established cell lines, and the opposing effects in hormone receptor — positive and negative tumors, measured using multiple in vitro and in vivo CSC assays, were consistent in all cases.

Although many posit that tumor cell heterogeneity is of a genetic basis associated with inherent high genomic instability in tumor cells, the heterogeneous cellular composition in tumors has also been hypothesized, early on, to be the consequence of abnormal tumor stem cell differentiation (9).

Although surgery is usually successful, some people may also need medications that lower cortisol or radiation therapy to destroy remaining tumor cells.

Round cell tumors are among the most common skin tumors in dogs, and they typically form just under the skin, although they may change the surface of the skin above them.

The exact cause of mastocytoma in dogs remains a mystery, although the current observation is that certain breeds of dogs such as Boston terriers, Labrador Retrievers, Boxers, Pugs, Beagles, Schnauzers, and Bulldogs seem to be more vulnerable to the formation of mast cell tumors.

Although some are benign, most mast cell tumors are cancerous.

Although mast cell tumors are common and are generally benign, any abnormal growth should be surgically excised and submitted for histopathology.

Although he has a history of T - Cell Lymphoma manifesting as a tumor on a loop of small intestine, the -LSB-...]

Unlike the canine situation, it is not all that helpful to stage the disease with buffy coat smears and bone marrow taps, although localizing the disease to the spleen with a splenic aspirate might be particularly useful as tumor cells in these locations have not altered prognosis.

Although they were once categorized as basal cell tumors, they have since been reclassified.

Although when first discovered, most dogs with OSA have «clean» thoracic radiographs (chest X-rays), there are usually tumor cells present in the lungs, but the masses are too small to be seen in routine radiographs.

Although tumors of the urinary tract are relatively uncommon in dogs, transitional cell carcinomas account for more than 75 % of bladder related cancer.

Although I am not a veterinarian, based on your description I believe there is a good chance that your ferret has insulinomas, which are small tumors of the beta cells of the pancreas that make a ferret's blood sugar drop.