Sentences with phrase «cell tumors appear»

Mast cell tumors appear to be more common in Siamese cats.

Not exact matches

Their paper, which appears in Nature Communications, describes how an immune cell recruited to the tumor induces the programmed suicide, or apoptosis, of the killer T cells harnessed by many immunotherapies.

Certain enzymes in normal skin cells deactivated 6 - HAP, the researchers found, and the tumor cells tested appeared to lack those enzymes.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

«Rac1 levels in invadopodia of invasive tumor cells appear to surge and ebb at precisely timed intervals in order to maximize the cells» invasive capabilities,» said Dr. Hodgson.

Pembrolizumab, or pembro, an immunotherapy drug that unmasks cancer cells and allows the body's own immune system to help destroy tumors, appears to be safe in treating lung cancers, according to a study by Cancer Treatment Centers of America ® (CTCA) at Western Regional Medical Center (Western) in Goodyear, Arizona.

Circulating tumor cell (CTC) clusters — clumps of from 2 to 50 tumor cells that break off a primary tumor and are carried through the bloodstream — appear to be much more likely to cause metastasis than are single CTCs, according to a study from investigators at the Massachusetts General Hospital (MGH) Cancer Center.

«While these tumors appear to be muscle cells under the microscope, and clinicians had thought that they arose from muscle progenitor cells, that didn't explain why the tumors can occur in tissues that don't have skeletal muscle, like bladder, prostate and liver,» he continued.

Lee's study results, which appear in the July 16, 2015 issue of Nature Communications, revealed new understanding about how 14 -3-3 sigma — a cell cycle «controller» - regulates cancer metabolic programming, thus protecting healthy cells from turning into tumor - producing factories.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

They found that cancer stem cells seemed to appear in the highest numbers along the edges of the engineered tumor environments, particularly where there were corners and convex curves.

In the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appeared.

The study, which appears August 3 in the peer - reviewed journal Nature Communications, showed that pairing the chemotherapy with an experimental drug eliminates the deadly population of cells believed to be responsible for repopulating the tumor.

Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the nervous system, have mutations in the ATRX gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.

Building on research recently published in Cell Reports, the researchers identified new mutations that appeared to be driving the strong drug resistance exhibited by these tumors.

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

When the first laser of light hits the circulating tumor cells, they appear to be fluorescent green.

The researchers also found that lymph node metastases appear to have developed from several different tumor cells that lodged in the nodes, not from a single tumor cell as is the case with many but not all distant metastases.

The mice appeared after surgery to be apparently «tumor - free»; yet, metastatic cells had already seeded from the small tumors.

«Most other tumors have a mutant p53, but in these testicular cell tumors, the p53 is functioning properly, and the drugs used for testicular cancer appear to work in concert with p53's tumor suppression function to kill the cancer cells.»

Scientists have known that LPA is secreted by many types of cancer cells, appears to promote the growth and spread of tumor cells, and that immune cells known as CD - 8 «killer» T cells have several receptors for LPA.

Viewed through the glasses, cancer cells appear to glow blue under a special light, thanks to a fluorescent marker injected in the tumor that attaches only to cancerous and not to healthy cells.

Part of that is because cancer cells in solid tumors appear to have learned how to «hide» better.

In a paper appearing online November 9, 2008 in the journal Nature, David Cheresh, Ph.D., professor and vice chair of pathology at the UC San Diego School of Medicine and the Moores UCSD Cancer Center and his co-workers mimicked the action of anti-angiogenesis drugs by genetically reducing VEGF levels in mouse tumors and inflammatory cells in various cancers, including pancreatic cancer.

In the new study, published online March 27, 2018, in Cell Reports, a team led by UCSF's David Raleigh, MD, PhD, found that increased activity of a gene known as FOXM1 appears to be responsible for the aggressive growth and frequent recurrence of these tumors.

Stimulation of the STING pathway appears essential to generate a de novo immune response comprising tumor cell death, generation of antigens, and activation of the innate and adaptive immune system.

«It appears that a conspiracy among three proteins is required to drive this most aggressive form of medulloblastoma, but the precise details of interaction still need to be worked out,» said co-author Charles J. Sherr, M.D., Ph.D., chair of the St. Jude Department of Tumor Cell Biology and a Howard Hughes Medical Institute (HHMI) investigator.

Specifically, some tumor cells appeared to express PD - L1, essentially «wrapping» themselves in it to avoid immune recognition and destruction.

Then, with the use of special equipment, the tumor cells will fluoresce or appear as bright blue tissue in the bladder.

In some cases, they even appeared to grow initially, as immune cells flocked to the tumors.

Possible reduction in certain types of cancer: «It appears to work primarily by blocking the growth and metastatic spread of tumors, controlling the cell cycle, and by reducing inflammation.»

The numerous flavonoids found in astragalus appear to enhance cell - mediated immunity by increasing the number of T - helper cell type 2 cytokines, increasing levels of tumor necrosis factor and interleukin - 6, which stimulates the activity of macrophages, responsible for killing potentially harmful cells.

It appears theanine competitively inhibits glutamate transport into tumor cells, which causes decreased intracellular glutathione (GSH) levels.

While canine mast cell tumors often appear small and insignificant, they can be a very serious form of cancer in dogs.

The tumors appear as sold growths which begin in the lymph nodes or bone marrow or as individual cells freely circulating in the blood, in which case they are called leukemia.