Sentences with phrase «cell tumors compared»

Boxers and bulldogs are more frequently diagnosed with mast cell tumors compared to other breeds.

Not exact matches

The favorable composition of flora were associated with a «higher activation status» of their killer T cells within the tumor compared to those who had an abundance of Bacteroidales.

Mouse tumors injected directly with the reprogrammed stem cells shrank 20 - to 50-fold in 24 — 28 days compared with nontreated mice.

Similarly, when these cells were injected into mice, the cells in which SLC13A5 was suppressed formed barely discernable tumors compared to the unmanipulated cancer cells.

By comparing the results to cells from paired normal tissue, researchers get a detailed molecular picture of the tumor environment, including the types and activity levels of T cells that are critical to the immunotherapy response.

Many more microchimeric cells are found in the blood of healthy women compared to those with breast cancer, for example, suggesting that microchimeric cells can somehow prevent tumor formation.

Analyzing a database of nearly 800 multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their tumor cells survived significantly longer over a three - year period compared to 159 patients with high ADAR1 levels.

Since the cancer cells in both types of tumors were the same, the researchers compared the noncancerous cells present in the induced and transplanted tumors to explore what might be causing the T cell apoptosis.

In mice, the Runx2 knock - in myeloma cells produced greater tumor growth and a wider spread of disease compared with the original myeloma cells; conversely, the Runx2 knock - down cells had less tumor growth and disease spread.

«Their immune systems may be less poised to detect foreign tumor cell grafts, compared to other species that have more genetic diversity.»

The team also compared the animals» responses to the therapy's effects in laboratory cell samples and found that in vitro studies did not predict how well the viral therapy and immune response would fight tumor cells in vivo.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

The tumors» recruitment of these inflammatory cells thus enabled them to resist what would otherwise have been a deadly dose of radiation, so that their growth slowed only modestly compared to control mice that had received no radiation.

Comparing the metastasized tumors with the original breast tumors, the researchers were surprised to learn that multiple, slightly genetically different cells from the original site had broken away together and established the new tumors.

Interphone compared surveyed cell phone use in 6,420 people with brain tumors to that of 7,658 healthy people in 13 developed countries — Australia, Canada, Denmark, Finland, France, Germany, Israel, Italy, Japan, New Zealand, Norway, Sweden and the U.K. — to try to determine whether people with brain tumors had used their cell phones more than healthy people, an association that might suggest that cell phones caused the tumors.

CNIO's Bioinformatics Unit has been key in comparing 900 cell lines derived from up to 35 tumor types in order to identify unique aspects of melanoma.

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

The researchers then compared tumor cells isolated from multiple different breast cancer patients and found that cells expressing lower amounts of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.

Tumor cells expressing p53 (left) have fewer focal adhesions (red) and lower levels of active p130Cas (green)-- rendering them noninvasive — compared with p53 - deficient tumor cells (riTumor cells expressing p53 (left) have fewer focal adhesions (red) and lower levels of active p130Cas (green)-- rendering them noninvasive — compared with p53 - deficient tumor cells (ritumor cells (right).

In tumors formed by human breast cancer cells, DNA damage (brown staining) is increased by simultaneous Olaparib treatment and PGAM1 suppression (right) when compared to either Olaparib treatment (left) or PGAM1 suppression (center) alone.

The protein seems to help cancers spread in people too: 50 % of colon cancer patients with high amounts of L1CAM protein in their tumors had the cancer spread within 5 years of treatment, compared to only 14 % of individuals with low amounts, the researchers reported here 13 December at a meeting of the American Society for Cell Biology.

Of all of these, one in particular caught the researchers» eyes: a microRNA called miR - 487b, which was consistently underexpressed in tumor tissue compared to healthy cells.

Using a very sensitive DNA analysis technique that can also be employed when only very small amounts of DNA from old tissue are available, the researchers could compare the two current cell lines with the tumor from which the cell line was established.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Investigators also demonstrated the malignant properties of tumor cells compared to the matched normal cells.

Their analysis showed that the diversity of T - cell receptors decreased among samples of T - cells taken closer to the tumor, compared with farther away.

Images taken with a fluorescent microscope show the activity of a kinase (green) in tumor cells (bottom) compared to normal cells (top).

«We discovered that the BRD4 gene has more of a gene - expression - guiding compound attached to it in tumor cells of a rare carcinoma (and several other cancers) compared to non-cancerous cells,» You said.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

But by sequencing the entire genomes of seven prostate tumors and comparing them with genomes from the patients» normal cells, the researchers discovered an unexpected phenomenon.

Injecting the TRAIL - expressing stem cells into the carotid artery, a likely strategy for clinical application, led to significantly slower tumor growth and increased survival, compared with animals receiving unaltered stem cells or control injections.

The study compared multiple techniques — or assays — used to analyze genomic data from a glioblastoma patient's tumor cells and normal healthy cells.

The importance of stromal POSTN was also demonstrated in another study in which orthotopic inoculation of gastric cancer cells into Rag2 − / −; Postn − / − mice reduced tumor size, decreased invasiveness, and decreased growth compared to Rag2 − / −; Postn + / + mice (Kikuchi et al., 2014).

The results of our limiting dilution analysis confirmed that the isolated CSCs (CD24 − / CD44 + / ESA +) population has significantly stronger ability of generating tumors compared with non-stem cell population (Table 1).

CRI: How does that level of tumor cell killing compare to non-engineered T cells?

We further determined that T cells deficient in DGKζ exhibit greater control of murine pancreatic tumor growth as compared with T cells deficient in Cbl - b.

Collectively, these data indicate that DGKζ − / − mice exert improved control of orthotopically implanted KPC1242 tumors, compared with WT mice, in a manner that may result from changes in the number of intratumoral activated CD8 + T cells in DGKζ − / − mice.

DGKζ - deficient mice also had enhanced control of pancreatic tumor cell growth compared with Cbl - b — deficient mice.

We sought to compare the signaling and functional effects that result from deletion of DGKζ, Cbl - b, or both (double knockout) in T cells and to evaluate tumor responses generated in a clinically relevant orthotopic pancreatic tumor model.

In a reciprocal manner, tumor - inoculated DGKζ − / − or DKO mice demonstrated a decrease in percentages of naive (CD44hiCD62Llo) CD8 + T cells within the spleen when compared with WT mice and, in the case of DGKζ − / − mice, when compared with Cbl - b − / − mice (Fig. 4C).

Further, consistent with T cell phenotypes in nontumor - bearing mice (Fig. 2), we observed an increased percentage of spleen - derived CD8 + T cells expressing high levels of the activation marker CD44 in DGKζ − / − or DKO mice that had been inoculated with tumor when compared with Cbl - b − / − or WT mice (Fig. 4C).

Compared with the untreated group and the groups treated with single agents, the number of apoptotic tumor cells was increased following combined treatment (Figure 4D).

When infused into mice bearing human tumors, CD26high T cells more efficiently reconstituted immunodeficient hosts and persisted long - term compared to other subsets.

To develop the methodology, the group analyzed the molecular profiles of human embryonic stem cells and compared them with data for 12,000 samples of 33 different tumor types held by The Cancer Genome Atlas (TCGA), a U.S. public database.

The Effect of p53 Status of Tumor Cells on Radiosensitivity of Irradiated Tumors With Carbon - Ion Beams Compared With γ - Rays or Reactor Neutron Beams

ONC201 combined with bortezomib in a Burkitt's lymphoma xenograft model reduced tumor cell density and improved CHOP induction compared to either agent alone.

One cohort study in Denmark looked at billing information from 358,000 cell phone users and then compared it to brain - tumor data from a national cancer registry.

Closely monitoring several markers of cell damage (including creatine kinase, lactate dehydrogenase, prostaglandin - E and tumor necrosis factor - alpha) in their sample of 18 male athletes (who used 20 grams of creatine monohydrate per day for five days, mixed with 60 grams of maltodextrine), the researchers found levels of these markers were reduced after the race, compared to 16 control subjects who took only the maltodextrine.

The apple extracts with skin significantly reduced the tumor cell proliferation when compared with the apple extracts without skin.