Sentences with phrase «cell tumors produce»

More than half of islet cell tumors produce excessive gastrin, which stimulates the stomach to overproduce acid.

Not exact matches

Capsaicin additionally produced a significant deceleration of the development of prostate tumors created simply by those human cell lines grown in mouse models.

If the tumor that Jobs had removed in 2004 had begun to break down prior to the surgery, White says, the tumor's dead cells could have released protease and lipase enzymes that may have damaged beta cells in the pancreas, which produce insulin.

The team was surprised to observe that these very aggressive tumors arise from mature, pigment - producing cells called melanocytes.

They found that the tumor cells produce a protein that acts like Velcro to attach the cells to the outer wall of a blood vessel.

With that knowledge, they screened more than four dozen monoclonal antibodies — unique agents that can stop cells from growing or forming tumors and can be mass produced — before finding two that block tumor creation in both types of cancer.

«Tumor cells often produce suppressive factors which essentially turn the brakes on tumor - killing white blood cTumor cells often produce suppressive factors which essentially turn the brakes on tumor - killing white blood ctumor - killing white blood cells.

Cheung and his colleagues genetically engineered mice to produce fluorescently tagged tumor cells.

In mice, the Runx2 knock - in myeloma cells produced greater tumor growth and a wider spread of disease compared with the original myeloma cells; conversely, the Runx2 knock - down cells had less tumor growth and disease spread.

Another challenge is producing stem - cell - derived tissues or organs that don't develop teratomas — tumors that contain a variety of tissues found in different organs — when transplanted.

The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.

Researchers at the University of Southampton have engineered cells with a «built - in genetic circuit» that produces a molecule that inhibits the ability of tumors to survive and grow in their low oxygen environment.

Indeed, after Siddle added a squirt of interferon - gamma — a chemical messenger that activates numerous genes involved in producing MHC antigens — to cells cultured from devil tumors, the MHC genes functioned normally again, and the tumor cells» identity cards showed up, plain as day.

Their stem cell - like properties enable them to maintain a pool of cancer stem cells within the tumor, as well as to produce new mature tumor cells.

«Tumor cells produce larger quantities of H2O2 and use oxidative signals at higher levels than normal cells in order to drive their own growth,» says Mirko Sobotta, first author of the publication.

The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

A team of researchers led by Julie Y. Djeu, Ph.D., associate center director of education and training at Moffitt, discovered that TGF - β produced by tumor cells causes NK cells to make high levels of a molecule called microRNA - 183 (miR - 183).

However, tumors produce high amounts of a protein called Transforming Growth Factor - Beta (TGF - β) that suppresses the activity of NK cells.

The traditional method of culturing tumor cells produces a single layer of cells that behave much differently from the original tumor.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

They found that if autophagy — the intracellular recycling process — is blocked in tumor cells, they produce cytokines that attract NK cells.

The research suggests that a cytokine produced by inflammatory cells near a prostate tumor induces cancer cells to decrease production of a protein that blocks metastasis.

The tool sprays a microscopic stream of charged solvent onto the tissue surface to gather information about its molecular makeup and produces a color - coded image revealing the nature and concentration of tumor cells.

One study showed that ovarian tumors produce a signaling molecule that serves to attract regulatory T cells, a subclass of adaptive immune cells responsible for quieting other T cells.

The more CCL5 is produced, the stronger tumors are infiltrated with NK cells.

The central idea is to encode an antigen as RNA and inject that into the skin of the patient, whose own cells then produce the protein that triggers an immune response, either to kill tumor cells or to prevent an infection.

Encapsulated toxin - producing stem cells (in blue) help kill brain tumor cells in the tumor resection cavity (in green).

Lee's study results, which appear in the July 16, 2015 issue of Nature Communications, revealed new understanding about how 14 -3-3 sigma — a cell cycle «controller» - regulates cancer metabolic programming, thus protecting healthy cells from turning into tumor - producing factories.

A team led by neuroscientist Khalid Shah, MS, PhD, who recently demonstrated the value of stem cells loaded with cancer - killing herpes viruses, now has a way to genetically engineer stem cells so that they can produce and secrete tumor - killing toxins.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

«Additionally, this provides evidence needed to begin investigating a vaccine in human cancer clinical trials to determine whether genetically modified tumor cells producing IL - 15 and IL - 15Rα may induce anti-cancer responses.»

Morris says vaccination with modified tumor cells producing IL - 15 and IL - 15Rα slowed tumor growth and led to increased survival for animal models.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

Cincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body's immune system, could initiate the immune response to fight cancer.

We have shown that T cells can locally produce commercial therapeutics (such as antibodies) in a solid tumor.

By contrast, 16 out of 17 mice that produced annexin A2 in their cells developed metastatic tumors in the liver, lungs or abdominal cavity.

The results suggest the simultaneous activation of certain molecular pathways — actions among molecules in a cell that can lead to change — in particular the MAPK and PI3K cellular pathways, triggered tumor initiation and produced increasingly dense low - grade gliomas that quickly progressed to glioblastoma multiforme (GBM).

Bone marrow biopsies often produce limited numbers of tumor cells to test — as few as 50,000 tumor cells in this study — but for this technique that is enough to test many different drugs and drug combinations.

Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that affect the nervous system, have mutations in the ATRX gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.

Recent research has suggested that tumor - infiltrating myeloid cells are initially produced in the bone marrow.

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin — the active ingredient in chili peppers — produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Nor was it possible to attract T cells into the tumor when the researchers transplanted non-activated eosinophils, which do not produce attractants, into the mice.

If a cell fails to produce the ultraconservated RNA, microRNA gets altered and hundreds of genes that should maintain cellular balance does and thus contributes to the formation of human tumors,» concludes Manel Esteller.

Furthermore, only those fusion - derived IEC - 6 cell clones that had undergone the changes in cellular growth indicative of neoplastic transformation produced tumors in mice.

IL - 6 is a cytokine, a signal molecule that is produced and secreted both by immune cells and by tumor cells and binds specifically to a receptor (IL - 6R) that is found on the surfaces of many cell types.

When the PBRM1 gene was knocked out in experiments, the melanoma cells became more sensitive to interferon - gamma produced by T cells, and in response produced signaling molecules that recruited more tumor - fighting T cells into the tumor.

Like all cells, tumor cells produce energy in two different ways: respiration, which requires oxygen, and glycolysis, which does not.

For example, scientists could engineer T cells, sentinels of the immune system, with genetic circuits that initiate a response to wipe out tumors when they detect the presence of two or three «biomarkers» produced by cancer cells, Lu says.

The RNA molecules direct which proteins the cell produces, so the RNA sequences show how tumor cells behave differently to normal cells.