«You should be able to convert any cell to
the cell type you like,» says the creator of a new biotech trick.
Essentially, they represent alternative ways of obtaining desired
cell types like heart cells, liver cells and, of course, neurons and glia.
Not exact matches
It's necessary to blend different
types of
cells to make lab meat that tastes
like the real thing.)
When you
type «= PV» in an Excel
cell, you get something
like what is shown in screenshot below:
Usually it's fatherly advice stuff
like «the 10 habits of financially secure people» or a list of the safest cities in America... sometimes it's cautionary stuff
like how my
cell phone might explode in my ear
type of thing — he usually circles the title of those to make sure I get the point — but lately he's gotten into sending me recipes, and I love it.
Certain infections,
like HIV; untreated, active tuberculosis (ok to pump); untreated brucellosis; active herpes lesions on her breast (ok to pump); and mothers who are positive for the human T -
cell lymphotropic virus
type I or II
These
cells protect many
types of tissues from infection, but they can also promote chronic inflammatory conditions
like Crohn's disease, which specifically targets the intestinal tract.
Despite that archaeal
cells were simple and small
like bacteria, researchers found that Archaea were more closely related to organisms with complex
cell types, a group collectively known as «eukaryotes».
Further ahead, he is looking to an emerging technology known as induced pluripotent stem
cells (iPSCs), in which adult
cells are reprogrammed to be
like embryonic stem
cells so they can transform into any
type of
cell.
This raises the possibility that,
like prion disease,
type 2 diabetes could be triggered by these deformed proteins spreading between
cells or even...
As the heart starts pumping a primitive blood -
like fluid around the body of an embryo, the change in pressure from the flowing liquid is the cue for
cells lining the aorta to change first into blood stem
cells, then into all blood -
cell types in the body.
«This reflects how
cells do not
like to change from one specialized
cell type to another and resist a change in
cell identity,» said Pasque.
«Just as normal
cells with the same genome differentiate into many different
cell types, a single tumor characterized by specific genetic mutations can contain many different
types of
cells — stem -
like and more differentiated
cells — with the difference being rooted in their epigenetic information.
The newly discovered human
cells, named «cord - blood - derived embryonic -
like stem
cells» or CBEs, are not quite as primitive as embryonic stem
cells, which can give rise to any tissue
type of the body.
In the latest study, the researchers hypothesize that the downregulation of these three genes reprograms the
cells so that they return to an embryonic -
like state, in which they have the potential to give rise to a number of different
cell types.
«We'd
like to extend this further to examine for driver genes in other
types of lung cancer, such as squamous
cell lung cancer.»
Other gene variants —
like mutations in FTO or the gene for leptin, an energy - balancing hormone — had been linked to overeating or fat
cell type.
By tweaking different fly genes and counting how many neuron
types were produced as the flies matured, the team identified a network of five genes that work together
like coordinated control switches to guide the precursor
cells» transformation to mature neurons.
«Disturbances to these processes may cause neuronal stem
cells to develop into different
types of
cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders
like schizophrenia.»
Now, with new kinds of technologies that are coming up, new
types of tissue engineering and, you know, some of the hopes that people have for stem
cells and [the]
like, it may be interesting to see if there are other ways, alternatives to dealing with really badly damaged hearts that would involve growing a new heart or replacing or repairing the damage d to a badly damaged heart that might make artificial hearts less important in the somewhat more distant future.
Energy - converting devices
like fuel
cells being developed to power some
types of electric vehicles rely on platinum's catalytic properties to transform
But
like the medieval alchemists, today's cloning and stem
cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a
cell's differentiation as smoothly as nature's program of development does every time fertilized egg gives rise to the multiple
cell types that make up a live baby.
In a related study, published in Cretaceous Research, OSU scientists announced the first fossil record of Rickettsial -
like cells, a bacteria that can cause various
types of spotted fever.
The drug's mechanism of action was entirely new: Instead of attacking cancer
cells (
like chemo), or indiscriminately revving up the immune system (
like IL - 2), ipilimumab blocked a single receptor on one
type of immune
cell.
«Maybe sour
cells are not directly linked to the unpleasant sourness that we perceive, but instead they may induce a different
type of taste,
like water, when stimulated.»
-
like cells, which produce insulin, to partially rescue a mouse model of
type 1 diabetes.
According to the researchers, stem
cells, which can generate all
types of intestinal
cells, are typically located deep within tube -
like crevices — called crypts.
Because biologists
like Daley are convinced that embryonic stem
cells — the most generic, versatile
type — may not only lead to dramatically different new treatments but can also uniquely illuminate the origins of disease in a way adult stem
cells never will.
«Use of induced pluripotent stem
cell (iPSC) technology» — which involves taking skin
cells from patients and reprogramming them into embryonic -
like stem
cells capable of turning into other specific
cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.
It plays an important role in how
cells sense their neighbors and, by controlling gene expression, determines which
cells should develop into different
types and how much they should grow -
like a master controller.»
The team found that individuals with long - standing
type 1 diabetes and diabetic enteropathy have altered colonic stem
cells (CoSCs) and increased blood levels of a regulatory protein called insulin -
like growth factor binding protein 3 (IGFBP3), which is produced in the liver.
«There are several diseases,
like certain
types of cancer and asthma, where stiffness of the
cell is known to be linked to the phenotype of the disease,» says Ming Guo, the Brit and Alex d'Arbeloff Career Development Assistant Professor in MIT's Department of Mechanical Engineering.
Low voltage T -
type channels generate tiny pulses of current at regular intervals by selectively passing positively charged cations across the
cell's membrane through a gate -
like channel.
This study shows that in conditions
like toxic shock syndrome, toxins from such bacteria can trigger one
type of immune
cells (MAIT
cells) to turn against the host.
The team learned that the
cells from the group of obese patients suffering from
type 2 diabetes had been reprogrammed and therefore did not function
like normal, healthy fat
cells.
At the time, Bell Labs was developing liquid - junction photovoltaics (a
type of solar
cell that employs liquid electrolytes), which seemed
like a nice fit for her electrochemical training.
The
cells transformed into the six major
types of retinal
cells and spontaneously arranged themselves into a layered cup -
like structure, mimicking the adult retina (Nature, DOI: 10.1038 / nature09941).
Their stem
cells, which can mature into any
type of tissue, were isolated and cultured in a dish around dots of gel -
like growth medium.
A potential solution to this problem is to reprogram other
cell types into functional beta -
like cells, which can produce insulin but are distinct from beta
cells and therefore are not recognized or attacked by the immune system.
Of course, it makes sense that viruses would choose to turn off genes that the immune system needs to fight the virus, «
like interferon - b, which is a highly anti-viral gene expressed in virtually all
cell types; or genes that T
cells need to recognize virus - infected
cells,» Kuss - Duerkop says.
At the same time, the organelles inside them looked
like those in
type II
cells.
Depositing the
cells with the micro-fabricated, funnel -
like insert allows the insert to be used with any
type of chip platform or
cell type, because it doesn't require patterning the chip's surface with different chemicals to adhere the
cells to it.
That single
cell contains all the genetic information needed to develop into a human, and passes identical copies of that information to each new
cell as it divides into the many diverse
types of
cells that make up a complex organism
like a human being.
By comparing hippocampal and cortical neurons in mono - culture (with other
cells of the same
type) and in co-culture (both
cell types deposited within one device), the research showed that some features from hippocampal
cells,
like the percentage of action potential spikes found in bursts, were significantly higher when cultured together with cortical
cells.
«
Like the gene itself, this region of the genome enables these stem
cells to maintain their ability to become any
type of
cell, a property known as pluripotency.
Jiang estimates that human clinical trials could begin within a decade: «At first, the
cells could be used to treat diseases with single missing or malfunctioning
cell types,
like hemophilia, diabetes, Parkinson's disease, and muscular dystrophy.
One potential treatment involves injecting the wound with stem
cells, which can change into other
cell types, such as skin
cells like keratinocytes, to help with the healing process.
The Mosers also found that the different
cells in the entorhinal cortex generate grids of many different
types,
like overlapping honeycombs — big, small and in every orientation and position relative to the box's border.
Although myeloma is,
like leukemias and lymphomas, a cancer involving white blood
cells known as lymphocytes, myeloma
cells don't traditionally express CD19 on their surface because they arise from the most mature
type of lymphocytes — plasma
cells.
The engineered
cells contain an antibody -
like protein known as a chimeric antigen receptor (CAR), which is designed to bind to a protein called CD19 found on the surface of B
cells, including the cancerous B
cells that characterize several
types of leukemia.