Sacha Escamez concludes in his doctoral dissertation that different
cell types work together to build the...
A complete Human Cell Atlas would give us a unique ID card for each cell type, a three - dimensional map of how
cell types work together to form tissues, knowledge of how all body systems are connected, and insights into how changes in the map underlie health and disease.
The organization of these tissues let different
cell types work together, to enable organs in the body to perform their functions.
Not exact matches
The squeeze mechanism Sharei and his colleagues came up with could also be more effective than other existing ways of getting materials into
cells, he says, because it
works for more
types of
cells and materials, and presents fewer risks.
They are an umbrella
type stroller but a little more durable with a basket underneath and a «cup holder» (although the cup holder
works better to hold your boarding pass and
cell phone vs. a hot drink).
«For example, brain enhancers will not typically
work in heart
cells, which means that you must test your enhancer sequence in the correct
cell type,» Dickel says.
Braun and Fan plan to test other ceramic -
type materials and determine if the experimental thermal emitters can deliver infrared light to a
working solar
cell.
Working with human breast tissue, the new study's authors attempted to induce EMT in normal
cells; they figured they would just get fibroblasts, a
type of connective tissue that is important in wound healing.
«To treat most forms of hearing loss, we need to find a delivery mechanism that
works for all
types of hair
cells,» said neurobiologist David Corey, co-senior investigator on the study and the Bertarelli Professor of Translational Medical Science at HMS.
«Different
types of cancer
cells with different strengths and weaknesses are both present in the tumor at the same time and can
work together to spread faster and more efficiently.
«Novel
type 1 diabetes treatment shown to
work on human beta
cells transplanted into mice.»
The first hESC was isolated in 1998, and researchers are still
working to find the strengths and nuances of each
type of stem
cell.
Once the animals had eliminated the parasites, both
cell types started
working again.
In the first practical application for the machine learning, the team
worked with Assistant Professor Jim Cahoon, Ph.D., in the UNC Department of Chemistry to design a new electrode material for a
type of low - cost solar
cells.
By tweaking different fly genes and counting how many neuron
types were produced as the flies matured, the team identified a network of five genes that
work together like coordinated control switches to guide the precursor
cells» transformation to mature neurons.
This
type of behaviour of the white blood
cells served as an inspiration for the postdoc, Daniel Ahmed, who was
working in Professor Bradley Nelson's research group at ETH Zurich.
«Our
work suggests that the neural pathology of autism manifests in the earliest cortical circuits, formed by a
cell type called subplate neurons,» said UMD Biology Professor and senior study author Patrick Kanold.
Previous
work from Dekker and colleagues had shown that points of interaction along the chromosome influence gene expression and are the reason why different
cell types are organized differently in three dimensions.
«The challenge is finding targets that exist on other
types of cancer
cells but not on normal
cells,» says pediatric oncologist Stephan Grupp of the Children's Hospital of Philadelphia, who
worked with Porter on testing the treatment in mice.
To make sure she understood how nuclei, dendrites, and axons came together to form different
types of brain
cells, she pulled out her crochet hook and went to
work.
The latter
type of research, in which human
cells or tissue are integrated into animals, was given the green light in the United Kingdom in October 2008, when the British House of Commons approved a bill that expanded the country's rules governing
work with human embryos.
X-ray-like imaging without the harmful radiation and
cell phones with more bandwidth are closer to reality now that researchers have developed a novel
type of lens that
works with terahertz frequencies.
New
types of solar
cells and flexible transistors are also in the
works, as well as pressure and temperature sensors that could be built into electronic skin for robotic or bionic applications.
But exactly how the immune system
works remains, in many ways, a mystery, as there are numerous
cell types whose functions and interactions with our immune systems have not been well understood.
But like the medieval alchemists, today's cloning and stem
cell biologists are
working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a
cell's differentiation as smoothly as nature's program of development does every time fertilized egg gives rise to the multiple
cell types that make up a live baby.
Professor Dan Davis and his team at the Manchester Collaborative Centre for Inflammation Research,
working in collaboration with global healthcare company GSK, investigated how different
types of immune
cells communicate with each other — and how they kill cancerous or infected
cells.
Although primed, post-implantation embryonic stem
cells can still turn into any
type of human
cell, they are more difficult to
work with than the pre-implantation, naive
cells.
Working with an animal model, the researchers found that a
type of
cell present in the brain's primary processing area during early development, long thought to form structural scaffolding with no role in transmitting sensory information, may conduct such signals after all.
«By identifying the full set of genes in each of these two
cell types, we provide detailed information that taste scientists can use to help understand how these
cells work, both when healthy and also when affected by damage or disease.»
The three genes, Cas, Eya and Hh,
work in various combinations, sometimes repressively, to determine which
types of
cells are formed.
With regard to taste, the findings will allow researchers to create a complete map of all the genes expressed in every
type of taste
cell within a taste bud, leading to a better understanding of how the taste system
works.
«Because of the Harvard Stem
Cell Institute, we were able to
work with other researchers to make patient
cells into any
type of neuron,» said Young - Pearse, whose lab spent two years fine - tuning protocols with collaborators to generate the neurons needed for her early onset Alzheimer's study.
Researchers do not know if the same thing would
work for other
types of cancer or cancer
cells lodged in other body organs.
Little has been known about the ways in which many diabetes genes
work, but a study published in the journal
Cell sheds light on a genetic risk component of
type 1 diabetes and a new approach for keeping beta
cells strong.
Lanza is also
working with hemangioblasts, intermediate
cells derived from embryos that can make all blood and vascular
cell types.
This could be a good way to test new
types of drugs that target cancer
cells specifically and spare patients the side effects from treatments if they are not
working.»
She is
working on a special
type of solar
cell that is made of organic - inorganic hybrid perovskites.
This allows users to determine either where their solar
cell would
work best or what
type of solar
cell they should use in their location.
Warnke's technique circumvents these limitations and could be adapted to
work with other
types of
cells.
Though a range of developmental scenarios in multiple brain regions is surely at
work in ASDs, the researchers said the ability to place these specific genetic mutations in one specific set of
cells — among hundreds of
cell types in the brain, and at a specific point in human development — is a critical step in beginning to understand how autism comes about.
«We don't yet know if this
type of coordination and control
works in stem
cell niches of other tissue
types,» says DiNardo.
Working with colleagues from the Center for Coastal Studies and NOAA Fisheries, van der Hoop used a load
cell to measure the drag forces on various
types of fishing gear collected from past right whale entanglements.
He is also
working on new receptor
types that could allow
cell therapies to more effectively penetrate disease sites and reside there for the duration of the treatment.
Kozai's lab is currently
working with Franca Cambi, professor of neurology at Pitt, on a project to understand the role of another
type of glial
cell on brain injury and neuronal activity.
In people with
Type 2 diabetes, the process appears to not
work properly, contributing to the destruction of beta
cells.
Professor Sheila Krishnadath from the Academic Medical Center in Amsterdam said: «We have been
working for over 10 years on collecting and
typing single
cells of this large group of Barrett's patients.
Medical researchers have been
working to use stem
cells, immature
cells that can develop into various
types of tissue, to regenerate cartilage.
Type I cells form the gas diffusing barrier and type II produce a mixture of lipids and proteins that work as a surfactant, regulating surface tension in the lu
Type I
cells form the gas diffusing barrier and
type II produce a mixture of lipids and proteins that work as a surfactant, regulating surface tension in the lu
type II produce a mixture of lipids and proteins that
work as a surfactant, regulating surface tension in the lungs.
This
work, which appeared online in
Cell, sheds light on the development and function of a cell type that is increasingly recognized as having an important role in the body's immune defe
Cell, sheds light on the development and function of a
cell type that is increasingly recognized as having an important role in the body's immune defe
cell type that is increasingly recognized as having an important role in the body's immune defense.
«Our
work is pointing to reserve stem
cells as being the critical players in conferring the benefits of intestinal - tissue regeneration after these
types of insults.»