Sentences with phrase «cell vaccines in»

Cyclophosphamide, doxorubicin, and paclitaxel enhance the antigen - specific anti-tumor immune response of GM - CSF - secreting whole cell vaccines in tolerized mice.

A paper he published early this year in the Journal of Clinical Oncology describes a dendritic cell vaccine in advanced glioma, an aggressive form of brain cancer.

Not exact matches

DPX - RSV is a small, B - cell epitope peptide vaccine targeting the unmet medical needs in respiratory syncytial virus (RSV).

An ND in Mountlake Terrace, WA who created my OWN cancer vaccine from my own immune cells.

While other papers have examined these mutations using expensive and time - consuming experiments on live ferrets and laboratory cell cultures, Deem and Melia Bonomo used the pEpitope method to rapidly calculate how much the egg - passage mutations would decrease vaccine efficacy in humans.

The long - term persistence of CD8αα + T cells where initial infection occurs may explain why patients have asymptomatic recurrences of genital herpes because these cells constantly recognize and eliminate the virus, according to Jia Zhu, Ph.D., corresponding author, research assistant professor in Laboratory Medicine at the University of Washington and an affiliate investigator in the Fred Hutch Vaccine and Infectious Disease Division.

And a new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

Not all vaccines are produced using the same antiquated system; for example, the HPV vaccine known as Gardasil, which was approved by the FDA in 2006, is made in yeast cells.

Managing pertussis outbreaks Aside from the difference in antigens, though, scientists remain unsure what made the whole - cell vaccine so effective.

«The best explanation for what we are seeing is that frequently, after exposure to HIV, a few cells in the genital tract are infected, without establishment of a systemic infection,» says senior investigator Eric Hunter, PhD, professor of pathology and laboratory medicine at Emory University School of Medicine, Emory Vaccine Center, and Yerkes National Primate Research Center.

The so - called STEP trial, sponsored by pharmaceutical giant Merck & Co. and the federally funded HIV Vaccine Trials Network (HVTN), was the first to test the idea of stimulating the immune system's killer T cells to hunt for the virus more aggressively, in this case using a weakened form of the cold virus to carry three genes from HIV.

The vaccine's effectiveness suggests there must be pre-existing cell - mediated immunity, possibly because of similarities between the surface proteins on swine flu and the seasonal H1N1 flu that emerged in 1977.

Both vaccines were based on live, weakened strains of polio virus grown in monkeys» kidney cells.

The momentum started building in 2010 when the FDA approved Provenge, a cancer vaccine that rallies male patients» immune systems to attack prostate cancer cells, allowing patients with an advanced form of the cancer to live several months longer.

Essentially, he's looking for immune cells with barcodes that proliferate in individuals with a good response, as opposed to those in whom the vaccine is ineffective.

Like all cancer vaccines, it's been a challenge to get dendritic cell immunotherapy to destroy tumors in people.

Schlesinger visited him only a week ago with data about an HIV clinical trial of a dendritic cell vaccine, and Steinman was absorbed in what she had to share.

«I'd love to have a stockpile of vaccine with both antibody and cell - mediated capabilities,» says Thomas Reichert of the Entropy Research Institute in Lincoln, Massachusetts.

For their research, Pekosz and his team, using human nasal tract cells, studied the weakened strain of the flu virus that is used in the nasal spray vaccine and compared its behavior with that of the flu virus itself.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

The personalized vaccine is made from patients» own immune cells, which are exposed in the laboratory to the contents of the patients» tumor cells, and then injected into the patients to initiate a wider immune response.

The vaccine also induced a sharp rise in CD4 T - cells, whose job is to mobilize the antibody response and other immune elements against viral infections.

Rewinding skin cells back to their origins in the womb could provide a powerful new vaccine against multiple types of cancer.

Using the findings from this study, the team has designed vaccine immunogens to selectively trigger the cooperating antibody - producing B cells to cooperate to make broadly neutralizing antibodies in a manner that mimics broadly neutralizing antibody development in natural HIV infection.

Tanyi and colleagues made each patient's vaccine by sifting through the patient's own peripheral blood mononuclear cells for suitable precursor cells, and then growing these, in the lab, into a large population of dendritic cells.

Fact: The WI - 38 and MRC - 5 cell lines, derived from two fetuses that were aborted, respectively, in 1962 in Sweden and in 1966 in the United Kingdom, are used to produce the following vaccines, all licensed and marketed in the United States:

In 1967 and 1968, Yugoslavia conducted a mass polio vaccination campaign using polio virus propagated in WI - 38 cells; Sweden and Switzerland had already run trials of the same vaccinIn 1967 and 1968, Yugoslavia conducted a mass polio vaccination campaign using polio virus propagated in WI - 38 cells; Sweden and Switzerland had already run trials of the same vaccinin WI - 38 cells; Sweden and Switzerland had already run trials of the same vaccine.

(In seeming contradiction, the report goes on to state, one page later, that «11 [current vaccines]... are produced using historic, fetal - derived cell lines.»)

Currently, most influenza vaccines in the United States are produced using chicken eggs, while a few are made in cell culture or by using recombinant DNA technologies.

Based at the Wistar Institute in Philadelphia, he was a gifted young scientist who reasoned that fetal cells derived from a normal pregnancy would be a virus - free and safe alternative for vaccine development.

Protein chemist Michael Way, cell biologist Sally Cudmore, and their colleagues at the European Molecular Biology Laboratory in Heidelberg and at the Pasteur Institute in Paris have found that vaccinia — a virus used in smallpox vaccines — surfs through cells on piles of actin, one of the basic structural proteins in the cellular skeleton.

This is important, because as the immune cells absorb CpG, they're also taking in the vaccine, which has been added to the package, much like your mother may have wrapped a bitter pill around something tasty to get you to swallow it.

CTL119 manufacturing begins with a patient's own T cells, some of which are removed and then reprogrammed in Penn's Clinical Cell and Vaccine Production Facility with a gene transfer technique designed to teach the T cells to target and kill tumor cells.

Crotty says the ability to measure Tfh cells in the blood will assist AIDS vaccine researchers by serving as an indicator of antibody response.

This seminal finding led to his recognition as an important scientist in vaccine design, and to his inclusion as a T cell expert in the CHAVI - ID vaccine consortium.

Bach2, an important gene for inducing memory B cells, may become an important target in vaccine strategies.

Then you activate the killer T cells with the dendritic - cell vaccine, so now you've got all your smart bombs and your cruise missiles coming in from outside.

Ups and downs of Ebola vaccines, home - brewed heroin, better solar - cell material, why lobsters turn from blue to red, and the first new class of antibiotics in years top a banner year for chemistry

The powerful, durable protection conferred by the candidate vaccine is due in large part to its strong stimulation of CD4 helper T cells, which are important for maintaining long - term antibody immunity.

These are «not the typical virus - fighting cells,» says co-author Gregory Poland, head of the Mayo Clinic's vaccine research group in Rochester, Minnesota.

The study included 124 newly diagnosed patients at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.

In particular, the researchers must ensure that their vaccine does not result in an autoimmune response to cells that produce ghrelin, which could trigger severe swelling and inflammatioIn particular, the researchers must ensure that their vaccine does not result in an autoimmune response to cells that produce ghrelin, which could trigger severe swelling and inflammatioin an autoimmune response to cells that produce ghrelin, which could trigger severe swelling and inflammation.

In Britain, in 1991, researchers led by Jim Stott at the National Institute of Biological Standards and Control in north London, stunned their colleagues by announcing that they had apparently protected monkeys from infection with the monkey virus SIV — the simian equivalent of HIV — with a vaccine based simply on human T cellIn Britain, in 1991, researchers led by Jim Stott at the National Institute of Biological Standards and Control in north London, stunned their colleagues by announcing that they had apparently protected monkeys from infection with the monkey virus SIV — the simian equivalent of HIV — with a vaccine based simply on human T cellin 1991, researchers led by Jim Stott at the National Institute of Biological Standards and Control in north London, stunned their colleagues by announcing that they had apparently protected monkeys from infection with the monkey virus SIV — the simian equivalent of HIV — with a vaccine based simply on human T cellin north London, stunned their colleagues by announcing that they had apparently protected monkeys from infection with the monkey virus SIV — the simian equivalent of HIV — with a vaccine based simply on human T cells.

In test - tube experiments with hamster cells, the DNA vaccine created mRNA that both copied itself like it would in the alphavirus and produced antigeIn test - tube experiments with hamster cells, the DNA vaccine created mRNA that both copied itself like it would in the alphavirus and produced antigein the alphavirus and produced antigen.

And a new analysis of the stopped STEP trial, published online Monday in Proceedings in the National Academy of Sciences, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development) used to distribute the inactive HIV strains can actually prime the immune system to be infected by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

Sun is currently conducting collaborative research with hydrogels for applications and efficiency with anticancer drugs screening and delivery, stem cells and wound healing, as well as being used in vaccines for H1N1 influenza and animal diseases, such as the porcine reproductive and respiratory syndrome virus, or PRRS.

And the key to vaccine success is that, afterward, the immune system starts to create fast - response infection fighters called memory cells that will circulate throughout the body and be able to recognize (and fend off) that same pathogen in the future.

The lab of co-author Rafi Ahmed, director of Emory Vaccine Center, has reported analogous cells in mice with chronic viral infections.

In theory, the ideal vaccine might mimic both antibody and T cell responses to block an infectious disease.

Researchers used IL - 15 to develop a whole tumor cell vaccine to target breast (TS / A) and prostate (TRAMP - C2) cancer cells in animal models; results showed that tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL - 15Rα was co-produced by the vaccine cells.