Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately
after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood
volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial
cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart
cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain
cells.96
Audi spent a couple of days in the hospital on supportive care
after starting chemotherapy to help avoid side effects of tumor lysis, a syndrome that can occur and make the patient very ill when a large
volume of tumor
cells are rapidly killed by chemotherapy.