Sentences with phrase «cells the disease team»

Not exact matches

Frey's team did not train their system to predict diseases, but instead to take measurements of contents within a cell (metrics such as the concentration of a specific protein) and draw conclusions about the cellular system as a whole.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Jiachen Lee, Arooba Ahmed and Jillian Parker, a trio of young scientists from the Half Hollow Hills school district won the $ 100,000 top team award in the prestigious Siemens Competition in Math, Science & Technology for their research into cell division that could help find treatments to cancers, viruses and other diseases.

A related paper, involving Svendsen, his colleague Gad Vatine, PhD, and a team from University of California, Irvine, published the same day in the journal Cell Reports, used a similar approach to study Huntington's disease.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

In a study, his team found that female incest survivors had abnormalities in the ratios of immune cells, compared with untraumatised women, exposing them to autoimmune diseases.

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

The team also needs to figure out which types of cancer Th17 cells respond to, and at which stage of the disease.

A team of researchers at the Stanford University School of Medicine has used a gene - editing tool known as CRISPR to repair the gene that causes sickle cell disease in human stem cells, which they say is a key step toward developing a gene therapy for the disorder.

In this latest advance reported in PNAS, the Wyss team showed that the human gut - on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to human health and disease.

The Porteus team started with human stem cells from the blood of patients with sickle cell disease, corrected the gene mutation using CRISPR and then concentrated the human stem cells so that 90 percent carried the corrected sickle cell gene.

Teams conducting research into treatment methods for various chronically inflammatory autoimmune diseases are already using the link between IL - 6 and pathogenic T cells today.

Svendsen is more optimistic about his team's work involving human tests of a novel stem cell approach to treat ALS, a degenerative motor neuron disease in which cells that transmit messages from the brain and spinal cord to the muscles wither or die.

Adding two blood - borne proteins associated with cancer cell migration increases the predictive ability of the current biomarker for pancreatic cancer to detect early stage disease, a research team from The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.

Using animal models of precancerous polyps in the bowel, Chung and his team determined that certain types of immune cells within a chronically inflamed intestine can become rewired, causing them — paradoxically — to contribute to disease development rather than protect against it.

A team led by Ken Zaret, PhD, director of the Penn Institute for Regenerative Medicine and the Joseph Leidy Professor of Cell and Developmental Biology, and Gloria Petersen, PhD, from the Mayo Clinic, identified a pair of biomarkers that physicians could soon use to discover the disease earlier.

Instead of misfolding the healthy prion protein, PrP, into amyloid fibrils, which have been linked to disease, the team combined the PrP with various blends of lipids — fatty molecules believed to misfold it in the cell.

A team from the Spanish National Cancer Research Centre (CNIO) has determined for the first time the high - resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer.

Next, the research team will examine specifically whether these liver cells obtained from human embryonic stem cells in a dish help repair injured livers in preclinical animal models of liver disease.

Kingsley's team had no idea what the normal gene does, but a team at the University of Tokyo had recently identified the genetic defect behind a similar mouse disease — and determined that its protein product normally generates pyrophosphate on the outside of joint cells to keep the joints scale - free.

«It's fantastic news that they are going into the clinic with a cell therapy for eye disease,» says Pete Coffey of University College London, and head of a team developing tiny «patches» of RPEs for treating age - related macular degeneration.

Yesterday, another Harvard team announced that it had generated disease - specific cell lines for nine other genetic diseases, including Parkinson's disease.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

Although some teams have managed to produce nearly pure colonies of certain kinds of neural cells from ES cells, no one has managed to concoct a recipe that will direct the cells to become, say, a pure population of dopamine - producing neurons that could replace those missing in Parkinson's disease.

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

The goal of the multi-institutional team is to develop genome engineering - based methods for correcting the disease - causing mutation in each patient's own stem cells to ensure that new red blood cells are healthy.

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

Once the team derived the stem cells, they identified a cellular mechanism that drives abnormal bone growth in the thus - far untreatable bone disease, called fibrodysplasiaossificans progressiva (FOP).

Findings from the study could help improve understanding of the causes of some diseases — including cancer — that are triggered by errors in the cell division process, the team says.

Haute's team plans to use the cells they created to study lung diseases, such as cystic fibrosis.

Using a yeast model of Parkinson's disease, Lee and his team discovered two of the compounds prevented the AS protein from clumping, effectively allowing the cells to grow normally.

The National Heart, Lung, and Blood Institute (NHLBI) has released the first comprehensive, evidence - based guidelines for management of sickle cell disease from birth to end of life, based on recommendations developed by a nationwide team of experts co-chaired by a UT Southwestern Medical Center hematologist.

The team led by Professor Bozec turned off the oxygen sensor HIF in B cells and observed that this prevented the resolution of inflammation, leading to chronic inflammatory diseases.

In order to locate all gene switches, the Freiburg research team used modern sequencing methods to examine the entire genome — DNA, epigenetic markers and RNA — during the development, maturation and disease of human cardiac muscle cells.

Johan Auwerx's team showed that the disease leads to a second cycle of events inside the cells, a series of reactions that exacerbate the disease's damaging effects.

The team generated stem cells from three people with Parkinson's and four without the disease.

British newspapers reported this weekend that Ian Wilmut, the University of Edinburgh biologist who led the team that in 1997 cloned Dolly the sheep, is getting out of the cloning business in light of the new findings, which seem to offer researchers a likely new source of stem cell lines for basic research that could one day lead to new treatments and perhaps cures for spinal injuries, diabetes and debilitating disorders such as multiple sclerosis and Parkinson's disease.

A team of researchers from Australia and France have uncovered new insights into how to prolong the lifespan of the body's disease - fighting natural killer (NK) cells.

«Endothelial cells play a very important role in multiple steps of many diseases, from initiation to the onset of clinical complications,» says Aikawa, who was not part of the research team.

Last May in Nature Neuroscience, his lab and a team at Columbia University reported that embryonic stem cells could be used to shed light on the origins of amyotrophic lateral sclerosis (ALS), the progressive neurodegenerative disease in which motor neurons in the brain die.

The team is now working with doctors at Massachusetts General Hospital, who hope to use the new, noninvasive technique to study cells involved in cancer, asthma, and other conditions in which cell properties change as a disease progresses.

In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone, published in Cell Host and Microbe, a scientific team led by the University of Wisconsin - Madison has identified signatures of Ebola virus disease that may aid in future treatment efforts.

The team found that most of the genetic changes in the original breast tumour were also present in the metastatic tumours, showing that the cancer cells spread late in disease development.

«Secondary benefits of this trial include the significant improvement in clinical care for children with sickle cell disease at each of the 29 sites because each location had a designated hematologist, neurologist, neuroradiologist and psychologist working as a team to identify and decrease further injury to the brain in this vulnerable population.»

Now that they have identified the long lived, skin resident T cell population that appears to be driving recurrence, the team plans to search for new therapies that can deplete these resident T cells, potentially driving the disease into long term remission.

An international research team led by biochemists at The University of Texas Health Science Center at Houston (UTHealth) reduced the sickling of red blood cells in a mouse model of the disease.

In additional experiments, the NYU team showed that the TB - transporting dendritic cells had to first pass through the lungs — as would be expected in the natural course of the disease that is passed by someone breathing in infected droplets — before heading to the lymph nodes to elicit a strong immune response.

The team discovered that a unique subpopulation of heart cells in diseased hearts activate gene programmes related to heart cell division, uncovering the gene expression heterogeneity of diseased heart cells for the first time.

A team of investigators led by Rohit Kohli, MBBS, MS, of Children's Hospital Los Angeles, has identified key inflammatory cells involved in nonalcoholic fatty liver disease.

«We believe that HO - 1 is a very early marker of metabolic disease,» says Esterbauer, whose team reports its findings today in Cell.