Sentences with phrase «cells accumulate damage»

Some researchers consider normal aging to be a disease, where our cells accumulate damage over time.

Not exact matches

These «triggers» can cause unwelcome byproducts to accumulate in the body and damage red blood cells.

Nishimura's team proposes that the same process leads to the reduction in stem cells in the follicles of older people, especially as DNA damage accumulates as we age.

His research interests encompass the characterization of all the «damage» accumulated in the molecules and cells of aging mammals, as well as the design of interventions to repair and / or counteract that damage.

The cells can accumulate a lot of damage,» Nair explains.

If the yeast's ribosomes jammed on the oxidized mRNA but were rescued by no - go decay, very little damaged mRNA would accumulate in the cell.

But if the factors involved in this quality - control system were absent, damaged mRNA accumulated in the cell, just as it does in Alzheimer's.

What these illnesses have in common is that they're caused by abnormal proteins that accumulate in or between brain cells to form plaques, producing damage that causes mental decline and early death.

Prof. Umeda says that the study provides a new paradigm for how plant cell division ceases upon DNA damage, thus preventing damaged cells from accumulating under stressful conditions.

These stressors can also cause XBP - 1s to accumulate in the cell's nucleus, which promotes the UPR and helps cells withstand the damaging effects of mis-folded proteins.

A group of researchers led by Kosuke Fujita, Visiting Researcher and Akito Maeda, Specially Appointed Professor at the HP Skin Regeneration, PIAS Collaborative Research, Osaka University clarified that cinnamtannin B - 1, or vegetable - based polyphenol, promotes the migration of Mesenchymal Stem Cells (MSCs) in blood circulation and accumulates them in damaged tissues (Fig. 1) to improve wound healing.

Green spots indicate a transcription factor that accumulates and inhibits cell division upon DNA damage.

In Alzheimer's, this protein — present in all healthy brains — can accumulate and clump, developing into cell - damaging plaque.

During sleep, a newly discovered network of water channels in the brain, called the glymphatic system, becomes active and functions as a waste disposal system, carrying toxins away which would otherwise accumulate and damage brain cells.

In HGPS, Progerin accumulates in cells and causes progressive massives molecular defects including nuclear shape abnormalities, chromatin disorganization, DNA damages and delaay in cell proliferation.

Does it look like this medicine would actually protect or nourish the nerve cell at the time or parallel to when the damage is accumulating?

The scientists think that phosphorylation enables neurons to remove more of the harmful protein so it does not accumulate and damage the cell.

In essence, the job of p53 is to make sure the cell does not accumulate DNA damage, or DNA mutations, which could eventually make the cell cancerous.

One of the characteristics of aging is that despite the panoply of repair efforts, cells accumulate random nuclear DNA damage.

Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Mcells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Mcells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MCells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to Mcells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).

When this happens, damages to DNA accumulate over time, causing cell damage, mutation and eventually, death.

Primary aging is what your body does to you even under the best of circumstances: cell and tissue damage that accumulates as a form of biological wear and tear, created as a result of the normal, healthy operation of metabolism.

If not degraded and removed, glycosaminoglycans can accumulate in cells and tissues, resulting in progressive, permanent damage affecting appearance, physical abilities, organ function and often mental development in young children.

Moreover, somatic mutation burden increases during a lifetime as a result of accumulating errors occurring either during cell division or because of environment - induced DNA damage.

On the other hand, such cells usually accumulate physical and chemical damage in the DNA - chain breaks, oxidized or otherwise modified bases.

The aim of WICT is the removal from the organismal environment of accumulated cellular and intracellular damage present in the patient's endogenous cells, including telomere depletion, nuclear DNA damage and mutations, mitochondrial DNA damage and mutations, replicative senescence, functionally - deleterious age - related changes in gene expression and accumulated cellular and intracellular aggregates.

Aging cells and tissues accumulate point mutations and genomic rearrangements, consistent with a failing ability to defend their genomes against DNA damage.

Despite the presence of the cell's antioxidant defense system to counteract oxidative damage from ROS, oxidative damage accumulates during the life cycle and has been implicated in aging and age - dependent diseases such as cardiovascular disease, cancer, neurodegenerative disorders and other chronic conditions.

When enough damage accumulates, cells can't survive properly anymore and they just simply give up.»

The human lifespan simply reflects the level of free radical damage that accumulates in cells.

These damaged cells accumulate in the body and cause inflammation.

When the cells are unable to detoxify, they end up accumulating excessive toxins and oxidative stress that damages the mitochondria and DNA.

Also, when glutamate, an excitatory neurotransmitter, accumulates in synapses in high concentrations, it may cause cell damage especially in the parts of the brain responsible for memory and learning.

The symptoms that you normally associate with aging (decreased mobility, decreased mental function, aches & pains, wrinkles, etc.) are also the result of accumulated damage from free radicals to your cells.

Science has now proven that almost every disease is the result of accumulated damage from free radicals to affected cells.

Flavonoids, which are found in a variety of fruits and vegetables as well as in tea, red wine, chocolate and berries, are thought to boost health in part by combating oxidation, a process in which cell - damaging substances called free radicals accumulate.

More damage could accumulate over time as the cell divides, which could lead to colorectal cancer.

According to the free radical theory of aging (FRTA), organisms age because of accumulated free radical damage to cells and DNA.

Solar cells don't self - replicate (yet) their performance degrades over time as damage accumulates.