Sentences with phrase «cells after injury»

He also studies how nerve cells can form new connections to neighboring nerve cells after injury.

«We were surprised that it was expressed in only a fraction of glial cells after the injury.

Not exact matches

LC - PUFAs are thought to be important for cognitive development because they are required for efficient neurotransmission (22) and are involved in neurite outgrowth, dendritic arborization, and neuron regeneration after cell injury (23).

The Regenerative Research Foundation in Rensselaer, an affiliate of the Neural Stem Cell Institute, will receive nearly one - fifth of the funds, or almost $ 1.1 million, for work aimed at promoting spinal cord regeneration after injury.

Most groups have focused on detecting proteins released from dying brain cells, but those proteins are not always abundant after injury and often require exotic or proprietary antibodies to measure, said study corresponding author Adam Chodobski, associate professor (research) of emergency medicine in the Alpert Medical School of Brown University.

Immune cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the nervous system clear debris, clearing the way for nerve regeneration after injury.

«We came up with a list of potential cellular candidates that could be compensating for the loss of these specific macrophages and used several different tests to determine which cells were clearing away the nerve debris after injury,» Lindborg said.

«We found that, contrary to popular belief, tissue stem cells derived from sick hearts do not contribute to heart healing after injury,» said Prof. Leor.

The findings suggest that damage to brain cells called interneurons disrupts neurotransmitter levels and plays a role in the development of epilepsy after a traumatic brain injury.

Together, studies in zebrafish and mammalian models could inform new ways to manipulate glial cells after human spinal cord injury.»

After a spinal cord injury, blood cells that normally couldn't enter the nervous system breech the protective blood brain barrier and flood the injury site.

Normally, after injury, immune cells invade the spinal cord and cause destructive and irreparable tissue damage.

To find out, Deb and his co-authors genetically tagged cardiac fibroblasts in mice and watched as they transitioned into bone - forming, osteoblast - like cells after heart injury.

Studying laboratory rats, Rutgers scientists found, however, that within a month after experimental brain injury, the number of new brain cells declined dramatically, below the numbers of new neurons that would have been detected if an injury had not occurred.

The excessive burst of new brain cells after a traumatic head injury that scientists have traditionally believed helped in recovery could instead lead to epileptic seizures and long - term cognitive decline, according to a new Rutgers New Jersey Medical School study.

While the regenerative capability of brain cells, in the hippocampus — the part of the brain responsible for learning and memory — slows down as part of the aging process, the Rutgers scientists determined that the process that occurred after a head injury was related to injury and not age.

A study published by Cell Press November 7th in the journal Cell has revealed that an evolutionarily conserved gene called Lin28a, which is very active in embryos but not in adults, enhances tissue repair after injury when reactivated in adult mice.

Partially paralyzed rodents walk almost normally after human embryonic or fetal brain stem cells repaired their spinal cord injuries in recent studies.

After other researchers reported that bone marrow stem cell therapy led to a modest but promising 5 percent improvement in the regeneration of sensory nerve fibers in rats with spinal cord injuries, he performed a critical reality check.

Since the same stem cells are responsible for helping heal the skin after injury, the study raises the possibility that Tregs may play a key role in wound repair as well.

If these niche cells can not make Wnts, mice do not develop adult intestines, and if these niche cells can not make RSPO3, mice can not repair the intestine after injury.

By using a dye that highlights damaged brain cells, they were able to monitor injury development in the slices up to three days after blast exposure.

The study introduced here focused on a population of support cells in the spinal cord that helps to protect surviving nerve cells (neurons) after injury: oligodendrocytes and their precursor cells.

Understanding the coordinated development of motor neurons and glia may inform ways to prod stem cells into generating more glia after someone suffers an injury with nerve damage.

This research provides new insights into the structure of the stem cell niche in health and after injury.

Akassoglou and her colleagues thought they had a good candidate in the gene for the p75 neurotrophin receptor (p75NTR), a regulator of cell death in the brain that also switches on soon after liver injuries.

Muscle stem cells are responsible for muscle repair after normal injuries and exercise.

The researchers picked one such experimental drug called RITA — Reactivation of p53 and Induction of Tumor cell Apoptosis — and used it to treat mice for a few days after cardiac injury.

«Using donor stem cells to treat spinal cord injury: Immune cells populating spinal cord after injury affect ability of stem cells to promote recovery.»

Twelve months after being injected with brain - derived stem cells near the injury site, one of the three human participants has regained some feeling in the lowest portions of his spine.

When scientists gave mice an oral drug called LM11A - 31 (designed to prevent neural degeneration in Alzheimer's patients) just hours after a complete spinal cord injury, it limited the death of cells that protect nerve fibers, allowing test rodents to retain their ability to walk and swim.

In a new study published in Restorative Neurology and Neuroscience, researchers found that inosine, a naturally occurring purine nucleoside that is released by cells in response to metabolic stress, can help to restore motor control after brain injury.

Dr. Gabriel Ferguson, a postdoctoral fellow in the lab of Dr. Martinez - Agosto and first author of the study, built upon the lab's previous research that utilized the blood system of the fruit fly species Drosophila, showing that a specific set of signals must be received by progenitor cells to activate their differentiation into cells that can work to fight infection after injury.

Many tissues contain a reserve of stem cells that help them heal and self - renew after injury or inflammation.

A new study in mice published in The Journal of Neuroscience details a potential therapeutic strategy that uses stem cells to promote recovery of motor activity after spinal cord injury.

The heart holds its own pool of immune cells capable of helping it heal after injury, according to new research in mice at Washington University School of Medicine in St. Louis.

In this study, the researchers found that conditional deletion of Sox2 — the gene encoding the SOX2 stem cell transcription factor — and the associated dampening of astrocyte reactivity appear to promote functional recovery, including behavioral recovery, after traumatic brain injury, said Dr. Zhang, a W.W. Caruth, Jr..

Studies in animals suggest that mesenchymal stem cells play important roles in the body's ability to heal after an injury, although researchers are still working out the signals and steps required to steer their differentiation into one type of tissue or another.

Normally, in the absence of injury, the tissue can tolerate the loss, due to the presence of the active stem cells, but, when you injure the animal, the regeneration is compromised and the enhanced regeneration after calorie restriction was compromised in the absence of the reserve stem cell pool.»

The researchers say their next step is to transplant the cells into mice with spinal cord injuries to see if the V2a interneurons can help to restore movement after damage has occurred.

«This is a clean demonstration that the physiological and metabolic benefits of exercise radiate to skeletal muscle satellite cells, the adult stem cells responsible for repair after injury, even in senescent animals,» said Thoru Pederson, Ph..

The Food and Drug Administration approved the trial in January 2009 but put it on hold last September because of safety concerns after lab animals injected with stem cells developed small cysts at the injury site.

Previous research has described at least some of the fundamental processes involved in healthy, on - going peripheral nerve growth regeneration, including the critical role of mitochondria — cellular organelles that produce adenosine triphosphate (ATP), the energy - carrying molecule found in all cells that is vital to driving nerve recovery after injury.

«A stem cell's job is twofold: to replace or recreate mature cells that are lost over time, both through normal aging and after injury, and to replace themselves so that the process can continue over the life of the animal,» said senior author John Ngai, the Coates Family Professor of Neuroscience and a member of UC Berkeley's Helen Wills Neuroscience Institute and the Berkeley Stem Cell Cencell's job is twofold: to replace or recreate mature cells that are lost over time, both through normal aging and after injury, and to replace themselves so that the process can continue over the life of the animal,» said senior author John Ngai, the Coates Family Professor of Neuroscience and a member of UC Berkeley's Helen Wills Neuroscience Institute and the Berkeley Stem Cell CenCell Center.

After spinal cord injury, axons try to cross the injury site and reconnect with other cells but are stymied by scarring that forms after the inAfter spinal cord injury, axons try to cross the injury site and reconnect with other cells but are stymied by scarring that forms after the inafter the injury.

Neuroscientists have long believed that scar tissue formed by glial cells — the cells that surround neurons in the central nervous system — impedes damaged nerve cells from regrowing after a brain or spinal cord injury.

After injuries of healthy tissues, we would like to accelerate the migration of healthy cells that move to close the wound.

«New insights on how cells regrow after being sliced in half: Researcher discovers method to speed up cell healing after injury.»

Best known for his Superman films, Reeve had long advocated research into embryonic stem cells to repair the kind of spinal cord injury that left him paralyzed from the neck down after a horseback riding accident 10 years ago.

Because of the work of several other collaborators, Haughey says, his team knew that some sort of inflammation - promoting molecule was released from brain and targeted to the liver after brain injury to send immune system cells to the damaged area, but the identity of this go - between had been elusive for years.