Not exact matches
At other times the
cell would be just an
aggregate.
To determine how
aggregates can arise in mitochondria and cause damage to
cells, they cooperated with the team led by F. - Ulrich Hartl
at the Max Planck Institute of Biochemistry.
The scientists, Nicole King and Arielle Woznica of the University of California, Berkeley, with collaborators Jon Clardy and J.P. Gerdt
at Harvard Medical School in Boston, discovered that within minutes after exposure to a chonodroitin sulfate (CS) lyase produced by V. fischeri, S. rosetta
cells aggregate into mass mating swarms, entering into
cell and nuclear fusion while duplicating and recombining their genetic material.
Intriguingly, brain
cells (neurons) with decreased complex I levels are significantly less likely to contain Lewy bodies, the abnormal protein -
aggregates that characterize Parkinson's disease,» says researcher Charalampos Tzoulis
at Department of Clinical Science, UiB.
By sweeping away AS
aggregates before they get a chance to spread, AS immunotherapies have the potential to hold the nonmotor symptoms of PD
at bay, slowing the overall progress of the disease, and — when combined with mature
cell therapy — eventually preventing the disease altogether, and potentially even reversing it.