Sentences with phrase «cells and tissue samples»

Pathologists examine cells and tissue samples to diagnose disease.

Counsel for a university in a dispute with licensee and in subsequent successful license negotiations involving patents related to the diagnosis and analysis of cells and tissue samples.

These results were also confirmed on human cells and tissue samples.

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

To address this gap in knowledge, Mirabello and Schiffman teamed up with co-senior author Robert Burk of Albert Einstein College of Medicine to sequence the whole genomes of 5,570 HPV16 - infected cell and tissue samples from women around the world and to identify associations between HPV16 genetic variants and the risk of cervical precancer and cancer.

Not exact matches

Scientists can create tissue to see how it will respond to chemicals or medicines, and an individual's own cells can be used to create a replica tissue sample for a more accurate forecast of how that person's body will react.

But scientists published in Cell Reports that they've discovered a way to regenerate those cells in mouse, primate and human tissue samples.

In cancer research, our goal is to be able to start with a sample of human tissue, extract many cells of interest, and perform genetic analysis upon each of them separately.

The biobank of MedUni Vienna and Vienna General Hospital is a central service facility dedicated to the storage of human tissue, cell material and body fluids for more in - depth diagnosis, academic research projects and clinical tests, as well as working - up samples by way of a medical service.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

In this study, rather than studying one iPS cell line, the researchers derived and sequenced 10 iPS cell clones from each patient tissue sample to get a better understanding of mitochondrial DNA mutation rates.

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab) model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.

They took cells from those tissue samples and successfully grew them on a three - dimensional scaffold to produce new vocal cords.

From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the lab.

But with this technique, we can just take a small sample of non-muscle tissue, like skin or blood, revert the obtained cells to a pluripotent state, and eventually grow an endless amount of functioning muscle fibers to test.»

Over the course of three years, Horvath and his team analyzed nearly 8,000 tissue samples from these datasets, which included blood, saliva and cells from organs like the brain and the colon.

They treated a variety of healthy tissues and 23 samples of cancer cells taken from leukemia patients with AG1295, a drug known to selectively block the kinase.

Scientists aim to freeze a sample of the boys» testicular tissue so that when they reach adulthood, spermatogonial stem cells (SSCs) found in the tissue can be reproduced and transplanted back into the patients.

«Our study addressed an important safety issue — whether cancer cells that might be present in testicular tissue samples can survive the process to replicate the sperm - producing stem cells,» said lead author Hooman Sadri - Ardekani, M.D., Ph.D., an instructor in urology and regenerative medicine at Wake Forest Baptist Medical Center.

The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.

The scientist tested their set - up using frozen human skin cells, segments of pig heart tissue, and sections of pig arteries in volumes almost 20 times larger than previously attempted samples.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

The solutions include better validation of tissue samples and cell lines.

Another popular technique for 3D cell imaging called spinning disc confocal microscopy can't image samples nearly as long as Betzig's technique, but it is still better for imaging thick cells and tissue.

Once they had established the chemical and physical details about the nanocrystals, the team then tested the particles as «staining» agents on a tissue sample containing liver cancer cells held on a microscope slide.

For the new study, described in the October 23rd issue of Nature Communications, scientists at the Johns Hopkins Kimmel Cancer Center and Dana Farber Cancer Institute in Boston collected tissue samples containing normal cells, ovarian cancers, metastases that had spread elsewhere, and small cancers found in the fallopian tubes, which included single cell layers of cancer called «p53 signatures» and serous tubal intraepithelial carcinoma, or STIC lesions.

Working with the brains of six normal children and seven autistic children ages 2 to 16, most of whom died of drowning, Courchesne has studied neurons under the microscope and even counted the number of neural cells in different tissue samples.

The study of human astrocytes has faced issues related to access (samples of living tissue must be obtained from brain cancer or epilepsy surgeries or fetal tissue) and purification (breaking apart astrocytes away from other cells often killed them and many experiments ended in failure).

They observed similar results in ART - controlled, HIV - infected patients who had undergone elective abdominal surgery: their SVF samples are positive for HIV DNA, and the researchers could show the presence of infected and virus - producing cells within the patients» adipose tissue and more specifically among adipose CD4 + T cells.

The rate of JAK2 amplification in these tissues was similar to samples obtained after chemotherapy, suggesting that JAK2 plays a supporting role in drug resistance and cancer stem cell - like features.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

UNISI provides expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a flow cytometric bead assay.

The major goal of the Animal Models and Cell Isolation Core will be to make available to members of NOAC tissue and cellular samples from control and ethanol - exposed animals.

Samples matrixes suitable for metabolomics analyses include in vitro: cell lysate and medium, and in vivo: Plasma, serum, urine, CSF, micro-dialysate and tissues

The researchers took healthy tissue and tumor samples from mice, and trained the nanoparticle - GFP sensors to recognize the bad cells, and for the GFP to fluoresce in the presence of metastatic tissues.

TNGB collects, stores and distributes high quality biological materials (nucleic acids, cell lines and tissue samples) linked to relevant clinical and genetic data from patients affected by inherited diseases.

Tissues being sampled include biopsy material from target organs, peripheral blood cells and serum / plasma, germline DNA, and stool for microbiota analysis.

To that end, Sharma gave an overview of MD Anderson's efforts to comprehensively characterize the activity of the immune cells in the patients they treat, and they've already analyzed over 42,000 tumor tissue samples, from both before and after treatment, looking for clues regarding how treatment outcomes relate to immune cell infiltration into tumors.

Guided by a camera and the ultrasound probe, Waxman carefully positioned the endoscope over the tumor and passed a fine needle into the pancreatic lesion to sample tissue cells for biopsy.

For setting cancer in the context of ageing tissue, study of normal adult homeostasis is important — we are studying mutational processes, clonal dynamics and cellular competition in thousands of non-cancerous cells and samples from a range of tissue types, in health and disease.

After more than a year of planning, the project had an easy - to - use, online consent form in which MBC patients could agree to share medical records, treatment history and tumor tissue and donate saliva samples (allowing researchers to analyze both their cancerous tumors and noncancerous cells).

The technique is insensitive to the level of mutated cancer cells in the sample, and the information about mutations can be linked directly to the way the tumour cells are growing in the tissue sample.

Researchers will be able to study samples ranging from engineered nanoparticles and nanostructures to naturally occurring biological polymers, tissues and plant cells.

3/24/2008 Non-Invasive Imaging Provides Window Into Genetic Properties of Brain Tumors Doctors diagnose and prescribe treatment for brain tumors by studying, under a microscope, tumor tissue and cell samples obtained through invasive biopsy or surgery.

There are many more glial cells in the brain than neurons, and astrocytes are the most abundant of the glia, so if you take a sample of brain tissue, you're fairly sure to get some astrocytes as part of the bargain.

At the heart of mass spectrometry is the ability to precisely measure tiny samples of substances such as chemicals in soil and water or cancer cells in a tissue sample.

For each cell line and tissue type, the average TPM value for replicate samples were used as abundance score.

Just fill up the vat with embryonic stem cell fluid, pop in a tissue sample and set the dial to «gestate.»

For a total number of 131 cell line samples and 172 tissue samples, mRNA sequencing was performed on Illumina HiSeq2000 and 2500 machines (Illumina, San Diego, CA, USA) using the standard Illumina RNA - seq protocol with a read length of 2x100 bases.