Sentences with phrase «cells and tissues where»

That means the antioxidants must be taken up by the digestive tract, enter the bloodstream and be delivered to cells and tissues where they can have an impact.

Not exact matches

To discover these targets, the team determined when and where each gene is turned on or off in the cells and tissues of H. contortus to reveal new insights into the worm's lifecycle.

Now, the team has examined whether sepsis has the same impact on tissue resident memory T cells (TRM), which do not circulate but stick to the skin, lungs, and gut — where infections often enter the body.

Skin TRM (seen in red) «sense» infections and «alarm» host tissue to recruit effector cells (green) to the skin where they contribute to viral clearance.

As might be expected of an autoimmune disease, where the immune system turns on healthy tissue, all the genes play a role in controlling the growth and multiplication of cells in the immune system.

To determine local immune control, where the invasive tissue interfaces with normal cells, post-birth placentas and stage - four melanoma tumors were examined.

Compared with unheated mice, the animals with the faux fever had twice as many white blood cells migrating out of the blood vessels and into the lymph tissue that lines the skin and gut, which is where they need to be to attack incoming pathogens.

They use a near - infrared laser beam, which can penetrate deep — in this context, deep means a centimeter or two — into the tissue, where a nanoparticle turns the near - infrared light into blue light, and that directs the activity of genetically engineered immune cells.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

The virus then enters and hijacks muscle and nerve cells where it replicates and travels up the nerves to infect the brain and other tissues.

But cancer biologists and immunologists have begun to realize that the progression from diseased tissue to full - blown invasive cancer often requires cells that normally participate in healing cuts and scrapes to be diverted to the environs of the premalignant tissue, where they are hijacked to become co-conspirators that aid and abet carcinogenesis.

As fat cells bulge, the body tries to store glucose in other tissues, including the liver, kidney, heart, muscles, and blood vessels, where the rotting process takes hold.

Proteomics researchers in Sweden plan to release a database next week containing hundreds of thousands of images of where different proteins are located in human cells and tissues.

«This is a unique platform to study interactions between drugs and cells or tissues, specifically in the kidney, where current models were lacking,» said Sakolish.

These pathologies fall broadly into four categories: coagulopathy, where abnormal blood clotting is caused; haemorrhaging, where bleeding occurs; neurotoxicity, which damages the nervous system causing paralysis, and cytotoxicity, where the bite causes death of cells and destruction of tissue.

Previous research conducted by Dr. Badylak's team suggested that ECM also could be used to regenerate lost muscle by placing the material in the injury site where it signals the body to recruit stem and other progenitor cells to rebuild healthy tissue.

There is evidence that chronic disabilities such as spinal cord lesions, diabetes, and Parkinson?s disease, where replacement of just one cell type restores tissue function, can be treated with differentiated embryonic stem cells.

When you're using certain tissue types that can't replicate multiple times outside of the body — liver and nerve cells, for example — «that's where stem cells are most relevant.»

To search for such cells, the Mosers and their team delved into the medial entorhinal cortex (MEC), a slim arc of deep brain tissue where they had discovered the grid cells in 2005.

The team detected neural tissue, cartilage, and liver cells in the areas of the scaffold where corresponding hormones had been applied.

And if the cells reach a tipping point where they completely block inflammation in fat tissue, they can cause fat deposits to build up inside unseen areas of the body, including the liver, leading to insulin resistance.

«Some cells that we call cancer stem cells adopt deadly characteristics where they can travel through the bloodstream to other tissue and form new tumors.

In this transition, cells lose the ability to adhere strongly to each other, enabling them to disperse and invade tissues, where they can become established and multiply.

Prins took human prostate stem cells from deceased young adult male organ donors and implanted the cells into mice, where they formed human prostate tissue.

These components then slip out of the fat cells and into the bloodstream, where they are accessible to tissues throughout the body.

These bacterial films may have duped researchers by growing into the channels and spaces where the T. rex's blood vessels and bone cells (osteocytes) had once been, mirroring both the shape and elasticity of soft tissue.

However, in animal tissues cells predominantly migrate in a three - dimensional environment, where they have to push through adjacent cell - layers and extracellular matrix.

Inflammation after tissue injury has two steps — an acute response, where white blood cells rush to the heart to remove dead tissue, and a resolving phase, where inflammation is dampened, reparative macrophages arrive, and scar tissue forms.

Immunologist Sharon Evans of Roswell Park Cancer Institute in Buffalo, New York, and coworkers are studying how fever affects the movement of white blood cells, or lymphocytes, from the blood into lymphoid tissue, where they learn to recognize and fight pathogens.

Infection happens in peripheral tissues, then the virus particles enter axons and zoom into the distant cell nucleus, where the viral genetic information can become latent, sleeping for days or even years.

The safe use of a stem - cell - based therapy against brain metastasis would require preventing the engineered cells from persisting within the brain, where they could affect normal tissue and possibly give rise to new tumors.

This is where vascular cells, connective tissue cells and hepatic cells engage in a complex communication.

Researchers at Whitehead Institute have uncovered a framework for regeneration that may explain and predict how stem cells in adult, regenerating tissue determine where to form replacement structures.

These cells line the mucosa, where they allow helpful substances to pass through to tissues in the body and also provide a barrier against harmful substances.

This might be feasible for muscle, where there are stem cells that are responsible for cell turnover within the tissue, but it will be very difficult for heart and brain cells, where cell turnover is very low or non-existent.

The new editorial policy for all APS journals requires the reporting of sex for cells, tissues and experimental animals and humans (i.e. male and female) or gender where appropriate and suitable for the experimental design of the research effort.

Scientists have found it difficult to distinguish between the cells that make up the entire mammary tissue and those where cancer begins, and have even debated whether there was anything to distinguish.

In pathological conditions, MSCs migrate preferentially into lymphoid organs, allografts, injured and / or inflammatory tissue sites after systemic transfusion, where they interact with the activated immune cells and modulate their function 51, 52.

Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.

On the other hand, there are many other tissues — notably, the kidney and articular cartilage — where p16Ink4a - expressing senescent cells appear to be a contributing factor to human and murine degenerative aging, but which were not evaluated in treated or control mice in this study, and it would be of interest to see the effects of ablation of p16Ink4a - positive senescent cells.

In a disease where human tissue is an essential resource, standardisation of cell lines and making them available to the community is incredibly important.

According to recent research, the most common solid tumors (that is, cancer that occurs as clusters of cells in or on organs, rather than in liquid form within the blood or lymphatic system) have up to 66 mutations that influence how the cancer cells operate — how fast they divide, whether they are susceptible to the signals that would normally cause a cell to die, when they detach from the main tumor to colonize another organ in the body, when and where they attach blood vessels to healthy tissues.

PD - 1 is a receptor present on activated T cells, which mediates immunosuppression primarily in peripheral tissues, where PD - 1 ligands, PD - L1 and PD - L2 share an immunosuppressive activity and may be produced by either tumor cells or stromal / tumor - infiltrating immune cells.

And in a certain case by Deepak Srivastava, where he could take skin cells and put them into a - make them into a heart, he actually took the master regulators of the heart cells themselves, these cell - specific regulators that tell a gene to turn on in a heart cell, and that turned these cells into a beating tissAnd in a certain case by Deepak Srivastava, where he could take skin cells and put them into a - make them into a heart, he actually took the master regulators of the heart cells themselves, these cell - specific regulators that tell a gene to turn on in a heart cell, and that turned these cells into a beating tissand put them into a - make them into a heart, he actually took the master regulators of the heart cells themselves, these cell - specific regulators that tell a gene to turn on in a heart cell, and that turned these cells into a beating tissand that turned these cells into a beating tissue.

March 31, 2018 - Some healthcare centers might showcase a shortage of organ donations, and this is where tissues regenerated using patients» own cells are highly helpful.

Multiplexed Imaging Here the goal is to add spatial resolution to cytometry - data in order to understand, in a tissue, WHERE immune and cancer cells interact We design, develop and apply methods for multiplexed visualization of protein and RNA molecules in tissue sections.

However, cancer cells often invade other tissues where the availability of certain nutrients is drastically different or grow so quickly that the blood supply, and the accessibility to oxygen and other nutrients that comes with it, becomes scarce.

Cancer cells often travel to other body parts where they grow and replace normal tissue.

Soft Tissue Sarcoma Opportunity: in both our monotherapy single arm Phase 1 and combination randomized Phase 2 studies, we are focusing on two types of sarcoma where we believe there is significant unmet need: synovial sarcoma and Myxoid round cell liposarcoma.

Sten Linnarsson (Karolinska Institutet / SciLifeLab), Joakim Lundeberg (KTH / SciLifeLab) and Mats Nilsson (Stockholm University / SciLifeLab) is leading the investigations, which aims to characterize cell types of brain, lung and heart tissue using single - cell RNA sequencing, and and make a three dimensional map of where the different cell types are located in the embryo.