Sentences with phrase «cells apoptosis in»

Phosphatase and tensin homologue (PTEN)- induced putative kinase 1 reduces pancreatic β - cells apoptosis in glucotoxicity through activation of autophagy.

Because it more effectively induces cancer cell apoptosis in p53 - deficient tumors, FL118 is especially effective against late - stage cancers, which usually lose functional p53 and are resistant to DNA - damage drugs.

«These findings suggest that BES may thus be used as a strategy to improve cell survival and prevent cell apoptosis in stem cell - based transplantation therapies,» Fan explained.

A study published in the Journal of Agricultural and Food Chemistry showed that in addition to strawberries, blueberries and black raspberries, blackberries, cranberries and red raspberries also had anti-cancer benefits, inhibiting cancer growth and stimulating cancer cell apoptosis in vitro.

Not exact matches

But in the following hours and days, the body's self - defense mechanisms backfire: White blood cells come in to clean up dead tissue, which causes massive inflammation, which in turn triggers healthy cells in the surrounding tissue to self - destruct in a process called apoptosis.

In May 2007 Newsweek Healthcarried an article stating that heart cells can remain alive for several hours even without oxygen, and that it is the sudden resumption of the oxygen supply, as attempts are made to resuscitate the individual in hospital, that causes apoptosis, killing the cells and causing deatIn May 2007 Newsweek Healthcarried an article stating that heart cells can remain alive for several hours even without oxygen, and that it is the sudden resumption of the oxygen supply, as attempts are made to resuscitate the individual in hospital, that causes apoptosis, killing the cells and causing deatin hospital, that causes apoptosis, killing the cells and causing death.

Cucurmosin has been shown to induce apoptosis in various cancer cells tested.

It looks like capsaicin is able to pull this off by instructing the mitochondria in cancer cells to undergo apoptosis, cell suicide.

Their antioxidant activity is known to inhibit cell proliferation and invasion, and promote apoptosis (cell death) in various cancer cells.

While doing her Ph.D., Wang came across a defense mechanism in plants involving apoptosis, where «the plant cell is induced to die around the infection site so the pathogen can not be spread to other tissues,» Wang says.

Since the cancer cells in both types of tumors were the same, the researchers compared the noncancerous cells present in the induced and transplanted tumors to explore what might be causing the T cell apoptosis.

In a study published in 2006, he and other Johns Hopkins researchers tested two compounds similar to CGP3466B to see if they would block GAPDH from triggering cell death under the types of highly stressful conditions that would normally cause apoptosiIn a study published in 2006, he and other Johns Hopkins researchers tested two compounds similar to CGP3466B to see if they would block GAPDH from triggering cell death under the types of highly stressful conditions that would normally cause apoptosiin 2006, he and other Johns Hopkins researchers tested two compounds similar to CGP3466B to see if they would block GAPDH from triggering cell death under the types of highly stressful conditions that would normally cause apoptosis.

Their paper, which appears in Nature Communications, describes how an immune cell recruited to the tumor induces the programmed suicide, or apoptosis, of the killer T cells harnessed by many immunotherapies.

«Our results are saying that if cells in these experiments are senescing and undergoing apoptosis, any conclusions we draw from that might not apply to what drugs are being tested on them, but from how the cells were derived,» Lanza says.

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

In patients with ALL, this leads to a sharp fall in serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.&raquIn patients with ALL, this leads to a sharp fall in serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.&raquin serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.&raquin malignant cells and inducing apoptosis, or programmed cell death.»

In her experiment, Wang starved cultured rat muscle cells in order to trigger apoptosis, a genetic program that instructs cells to self - destrucIn her experiment, Wang starved cultured rat muscle cells in order to trigger apoptosis, a genetic program that instructs cells to self - destrucin order to trigger apoptosis, a genetic program that instructs cells to self - destruct.

Cells commit suicide all the time, a phenomenon called apoptosis, in which the body rids itself of old or unnecessary cells (see «Apoptosis,» on pageCells commit suicide all the time, a phenomenon called apoptosis, in which the body rids itself of old or unnecessary cells (see «Apoptosis,» on apoptosis, in which the body rids itself of old or unnecessary cells (see «Apoptosis,» on pagecells (see «Apoptosis,» on Apoptosis,» on page 73).

The research group in Israel showed «that the Spalax p53 suppresses apoptosis (programmed cell death), however enhances cell cycle arrest and DNA repair mechanisms,» he said.

If we introduced stem cells with nice, long telomeres in the first place, we could let them wind down and eventually be lost to apoptosis, senescence, or other sources of damage — and just top our tissues up with more stem cells before enough of those cells were lost to begin to impair tissue function.

In so doing the caspace cascade kills the cell — causing apoptosis.

Programmed cell death, or apoptosis, is a natural process that kills billions of cells in a typical human body each day.

Particularly prominent in the RNA - Seq analysis was the up - regulation of a number of granzymes, a group of proteinases secreted by immune cells that were originally thought to be involved in killing (via apoptosis) virus infected cells or other target cells.

Researchers at Texas Woman's University have shown that a diterpene geranylgeraniol found in linseed oil, Cedrela toona wood oil, sucupira branca fruit oil and more recently, annatto seed oil, suppressed the viability of human DU145 prostate carcinoma cells via cell cycle arrest at the G1 phase and the initiation of apoptosis.

New research shows that microRNA - 486 is a potent tumor - suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung - cancer cells, and the induction of programmed cell death, or apoptosis, in those cells.

JAK1 is part of a well - studied regulatory network of proteins that is involved in the control of cell growth, differentiation, apoptosis, inflammation, and immune response.

UJ3 appears to target the mitochondria, resulting in programmed cell death to kill cancer cells — a process called apoptosis.

Researchers were able to quantify the protective effect of dexamethasone treatment in protecting both satellite glial cell and neuronal apoptosis; in contrast, meloxicam treatment was only effective in protecting against satellite glial cell apoptosis and only after prolonged administration.

One of the genes that MM41 blocks — the BCL - 2 gene — is involved in regulating apoptosis, the body's natural process which forces cells to die if they become too damaged or unhealthy to be repaired.

The distinction between apoptosis and cell lysis is important in immunology - lysing a virus - infected cell would only release the virions, whereas apoptosis leads to destruction of the virus inside.

BCL - 2 is present in high amounts in many tumors and helps cancer cells to survive, but when the BCL - 2 gene is blocked by MM41 in mice, the cancer cells succumb to apoptosis and die.»

And if apoptosis fails to destroy damaged cells in adults, it can lead to cancer.

ABT - 737 targets proteins known as B - cell lymphoma 2 (Bcl - 2) and Bcl - xL, which prevent apoptosis, a form of cell suicide, in cancer cells.

Finnish scientists from the University of Helsinki, investigating how Myc re-engineers metabolic pathways in cells, have identified an unexpected branch in the pathway - a branch that ends to cell death (apoptosis).

The figure shows a confocal microscopy image of a mammalian cell undergoing apoptosis with the mitochondria stained in magenta and the protein Bax in green.

This pathway, the investigators report in Nature Medicine, is very similar to apoptosis (the controlled cell death program thought to exist only in multicellular organisms), but with subtle differences suggesting that it could be specifically targeted for anti-parasitic or - microbial drug development.

Jon Tilly, the director of the Vincent Center for Reproductive Biology at Massachusetts General Hospital in Boston, has been studying genetically altered mice to better understand the process of apoptosis, or natural cell death.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damagIn addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damagin CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

In the current issue of Nature Medicine, John Pezzuto of the University of Illinois at Chicago and his colleagues report that a compound called betulinic acid triggers apoptosis or programmed cell death, in cultured melanoma cellIn the current issue of Nature Medicine, John Pezzuto of the University of Illinois at Chicago and his colleagues report that a compound called betulinic acid triggers apoptosis or programmed cell death, in cultured melanoma cellin cultured melanoma cells.

Dr. Su and her collaborators at University of Colorado, Boulder used ionizing radiation (IR) to induce DNA damage and apoptosis in cells of the wing imaginal disc, the immature form of the fly's wings.

Activation of the Fas receptor then induces apoptosis in these cells.

In the process, the plasma membrane receptor Fas (CD95) is key; this cell receptor occurs in almost all human cells and is involved in programmed cell death (apoptosisIn the process, the plasma membrane receptor Fas (CD95) is key; this cell receptor occurs in almost all human cells and is involved in programmed cell death (apoptosisin almost all human cells and is involved in programmed cell death (apoptosisin programmed cell death (apoptosis).

«This suggests that cancer cells that acquire mutations in genes that drive apoptosis will lose sensitivity to BET inhibitors and thus will be able to survive treatment, leading to disease relapse.»

Specifically, they are required in processes in which mammary cells lose their normal polarity, or spatial orientation; and in which the cells lose the ability to commit preprogrammed suicide, or apoptosis, upon detection of gross abnormalities.

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

They found that Fusobacterium nucleatum in the gut can stop chemotherapy from causing a type of cancer cell death called apoptosis.

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

«In modern biology mitochondria are considered to be much more than the powerhouse of the cell; they integrate multiple intracellular signals to regulate progression through the cell cycle and into apoptosis.

However, in developing brain cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished stem cell differentiation into brain cells and increased cell suicide, a carefully controlled process known as apoptosis.

«BOK is an effector of mitochondrial apoptosis that appears to work in a different way to known proteins that initiate mitchondrial cell death,» said Fabien Llambi, Research Laboratory Specialist at St. Jude and the first author of the paper.