Sentences with phrase «cells as model systems»

We investigate cellular and molecular mechanisms of retinal degeneration and regeneration using rodents and human cells as model systems.

Not exact matches

Using the mouse as an experimental model, LMU neurobiologist PD Dr. Conny Kopp - Scheinpflug and her research group have now demonstrated that the activity of nerve cells in the auditory system has a direct effect on myelinization — higher levels of activity correlate with the formation of thicker myelin sheaths.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

The NB activity in Alberta is far ranging, with such research as self - assembled nanostructures (M. J. Brett), single - cell cancer analysis (L. M. Pilarski), computational modeling (D. Wishart), micro-total analysis systems or lab on a chip (D. J. Harrison), cell identification and manipulation (K. Kaler), and microsystems and medical diagnostics (Backhouse).

A second type of immune system cell, called regulatory T cells (Tregs), are a model of constancy, remaining stable even as Teffs go into battle mode.

However, he added, the patient - derived iPSCs are highly useful as a model cell system for investigating blood disorders.

More recently, researchers have induced stem cells from diseased human somatic cells, which may serve as new model systems for various illnesses.

Here they used the UK - developed EPOCH «particle - in - cell» code, where particles are modeled as «chunks» that describe the bigger reality of the dynamics of the plasma system.

Dr Sottile added: «This new system gave us an advantage over previous rodent models as we could study more accurately how specifically human cells would be affected by a decrease in temperature.

We have been using cell culture models and zebrafish as an assay to determine the effects of BMP on signaling, but we also want to be able to understand what the effect of the mutation is in the tissue and organ systems.

«With Teresa Woodruff's research using Draper's human organ system platform, we have a compelling demonstration of the importance of a microenvironment that permits cells to function in vitro as they would in vivo, and the power of being able to interconnect organ models on a platform and operate them in a stable and precise manner for weeks to months,» said Jeffrey T. Borenstein, a biomedical engineer at Draper.

«As a powerful model system for studying adult stem cells, Drosophila female GSCs have revealed many novel regulatory strategies which have been later confirmed to be generally true,» adds Su Wang, a co-first author of the paper and also a graduate student in Department of Anatomy and Cell Biology at University of Kansas Medical Center.

By using fruit fly as a model system, Minna Poukkula working at the Institute of Biotechnology, University of Helsinki, has found out how actin - rich protrusions contribute to cell migration in animal tissues.

Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.

The research group, led by Erika Matunis, Ph.D., a professor of cell biology at the Johns Hopkins University School of Medicine, has been using the fruit fly as a model living system in which to study stem cells in their natural state.

«We've shown, in a model bacterial system, that the chemistry of cadmium allows it to bypass the mechanisms that prevent other metals, such as iron and zinc, from freely entering cells.

In recent years cultured Drosophila S2 cells have been used extensively as a model system to study infection and immune responses.

This murine model system offers a superior source of immortalized cell populations as many of the difficulties associated with the in vitro transfection process are eliminated (e.g., initial requirement for many cells, different sites of gene integration, multiple copy number; Ref.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

Researchers from the Gladstone Institutes, in collaboration with scientists at UC Berkeley, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.

He uses the paradigm of nuclear hormone receptor activation / signaling and the contribution of this process to myeloid cell differentiation, function, and to diseases, involving these cells, such as atherosclerosis, tissue regeneration, metabolic, and various inflammatory disorders, as his model systems.

Lindquist, who started as a fruit fly cell biologist, now tracks warped proteins and their consequences through model systems spanning millions of years of evolution

Teachers appreciate this facility, because it allows students to model Hardy - Weinberg equilibrium in gene systems under selective pressure — such as the sickle cell mutation.

The Polonis lab has also employed both cell line - based model systems, as well as primary cell types from uninfected humans, to investigate virus - antibody - host cell interactions and cross-subtype reactivities amongst the major subtypes of the HIV pandemic.

Consisting of optimized media and reagents, MimEX ™ Tissue Model Systems provides an alternative to current 3 - D cell culture modes, such as organoids, with the added benefit of...

Single - cell technologies will be applied to experimental model systems such as organoids, miniature organs grown in the petri dish from one or more cells.

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.

We study the cell biology, binding proteins, structure and regulation of these important enzymes, using neuroendocrine cell lines as model systems.

We also aim at understanding how different cilia are built and we use drosophila as a model system to understand the specialized function of ciliary genes in different ciliated cells and ciliary sub-compartments.

Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment.

However, hiPS cell - derived hepatocytes are only useful as an in vitro model system and for gene editing applications if they recapitulate critical hepatocyte functions.

His research focus is the theoretical analysis of stem cell organization using system biological approaches such as mathematical modelling and computer simulation.

Previosly in a preclinical study BRAF inhibitor - resistant mutated BRAF melanoma cells were developed as an experimental model system to mimic BRAF inhibitor - resistant melanoma patients and to study the mechanisms of resistance.

The authors note that the formation of each different organ bud type may require some fine tuning to optimize tissue self - organization, and further addition of neural cell types may be necessary, but this research may soon provide exciting model systems for the study of basic biology and pathology as well as providing appropriate replacement tissues for the treatment of many patients with no other viable options.

Biocellion is being used to model a variety of biological system behaviors, such as biofilm formation and wrinkling, microbial growth dynamics in complex soil structure, brain tumor growth and invasion, formation of complex bacterial colonies, and changes in blood vessels and skin cells.

Our lab uses a variety of model systems, such as the nematode C. elegans, as well as in vitro culture systems, to address fundamental questions in cell cycle control during development and tissue formation.

Today, analyzing and editing genomes, proteomes and metabolomes has become a standard for many model systems; imaging beyond the diffraction limit of light and new technologies for studying protein structures provide insights deeper than ever before; the characterization of large populations of cells or organisms brings unprecedented statistical power; and studying nearly all organisms of an ecosystems as a whole allows generating comprehensive models.

Her research focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

His research utilizes molecular biology, cell culture, and animal models to study your body's cannabinoid system in an attempt to further our understanding of Cannabis as a medicine, and possibly lead to the development of new drug compounds.»

My lab is investigating basic mechanisms of patterning and morphogenesis in epithelia — we use the developing wing of drosophila as a model system and apply genetic, cell biological and physical tools to its analysis.

Chlamydomonas is used as a model system for research on many very fundamental questions in cell and molecular biology: how do cells move?

Enriched by the rapid evolution of these technologies, TEFOR - TACGene has developed a solid expertise in the design, production and use of TALE - N and CRISPR / Cas9 systems, both for its own research projects in cultured cells and in collaboration, in many model organisms, including the rat, zebrafish, Drosophila, and Xenopus as part of the National Infrastructure in Biology and Health TEFOR supported by Investissement d'Avenir programme (2012 - 2019).

The researchers first discovered ascarosides as a signaling molecule in C. elegans, a nematode used as a model organism to study cell, developmental and nervous system biology, as well as human aging and diabetes.

Using the oral microbial community as a model system, we are applying functional genomic approaches including Stable Isotope Probing (SIP), metatrascriptomics and directed single cell genomic approaches to enable us to overcome this limitation.

In particular, I focus on chromosome segregation and cell division, using the nematode C. elegans as a model system.

Modeling how blood and cells, such as cancer, flow in that system offers insight into disease diagnosis and treatment.

SAN FRANCISCO, CA — Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.

We use gut as model system to study cell migration in homeostasis, wound healing and cancer invasion (Fig. 1).

Researchers gain valuable information about the strengths and weaknesses of our immune system using mouse cell models such as used here.

Dr. Locksley's laboratory focuses on tracking cytokine expression in model systems, as a mechanism to investigate complex functional interactions between innate and adaptive cells in the immune system.