Sentences with phrase «cells at high concentrations»

Not exact matches

Nanog appears in both the morula (12 - cell stage) and in high concentration at an advanced stage of normal embryonic development, the blastocyst (150 - cell stage).

«Instead of promoting infection, at higher concentrations, BX795 actually helped cells clear the infection.»

At the end of the study, children who lived in neighborhoods with the highest concentrations of nitrogen dioxide and particulates had experienced greater declines in insulin sensitivity and had signs of impaired pancreatic beta cells, which produce insulin.

At even higher formaldehyde concentrations of 3.0 milligrams per cubic meter, however, the researchers observed an unexpected decrease in cilia beating frequency, possibly due to irreversible cell damage caused by the formaldehyde.

After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the body.

At much higher concentrations, chlorine could damage the cells in our body.

But at higher concentrations, and under the right conditions, melittin molecules group together into rings creating large pores in membranes, weakening a cell's protective barrier and causing the entire cell to swell and pop like a balloon.

Capture experiments were also performed on whole blood samples, and the capture efficiency was in a high range of 81 - 95 %, at different tumor cell concentrations.

Physicists of Ludwig - Maximilians - Universitaet (LMU) in Munich now show that, at high concentrations, a crucial protein can assemble into ring - shaped filaments that constrict the cell, giving rise to two daughter cells.

They found high concentrations of sensors known as Merkel cells at the base of tiny hairs that cover the wings, they report online today in Cell Reports.

In addition, LDD patients had abnormally high concentrations of the CILP protein in their lumbar disks.To see what effect the mutated CILP protein has at the cellular level, the researchers added it to rabbit disk matrix cells grown in a Petri dish.

These nanomembranes maintained their structure in water or alcohol, at different temperatures, in solutions with high or low pH, or high concentrations of salts, a feat that few cell membranes could accomplish.

Antibiotics can be categorized based on whether they directly kill bacteria (bactericidal) or slow growth / prevent cell division (bacteriostatic); however, the distinction between the two categories may be a bit of a gray area as some bacteriostatic reagents can kill bacteria when used at high concentrations (and vice versa).

Further, although we could detect enhancement of granzyme B production in DKO T cells relative to WT, DGKζ − / −, or Cbl - b − / − T cells at early time points (Fig. 3B, upper panels), we did not observe enhanced granzyme B production in DKO relative to DGKζ − / − or Cbl - b − / − T cells at later time points (Fig. 3B, lower panels), at higher or lower concentrations of anti-CD3 Ab, or with addition of anti-CD28 Ab (Supplemental Fig. 2B).

Elevated TRF2 expression in clonospheres at high concentration of Bleomycin may contribute to increased expression of stem cell factors.

Similar indolone compounds had been found to inhibit cell death but were toxic at higher concentrations.

Since we know the Gal4 - UAS system is sensitive to temperature and in fact, expression levels of these transgenes differ at 22 °C and 25 °C, Drosophila GBPs might also suppress ILP secretion from the insulin - producing cells when expressed at high concentrations.

Moreover, annexin V / propidium iodide staining showed that VPA only marginally decreased the viability of in vitro — differentiated Th1 and Th17 cells at a relatively high concentration (1 mM)(Supplemental Fig. 4A, 4B), whereas VPA readily inhibited the differentiation of Th1 and Th17 cells at a low concentration (0.2 — 0.5 mM), indicating that apoptosis induction was not the primary mechanism for Th1 and Th17 cell differentiation inhibition (28, 29).

At low concentrations, the cells» photosynthesis apparatus recovered within five hours, and recovery mechanisms were sufficient to deal with all but the highest concentrations tested.

despite its controversy in mainstream medicine that antioxidants counteract chemotherapy, at the high concentrations achieved intravenously, vitamin C acts as a prooxidant and is toxic to tumor cells.

* Oddly enough, however, the experiments with fresh pancreatic islets and fat cells taken from the mice suggested that the positive effects of uncarboxylated osteocalcin on insulin only occurred at concentrations extremely low compared to those of undercarboxylated osteocalcin normally present in mice, while the effects on adiponectin and energy expenditure only occurred at normal to high concentrations.

The addition of sacha inchi oil slowed down glucose production in 16 (38.1 %) participants that showed a higher concentration of triglycerides before meals (fasting hypertriglyceridemia), whereas an improved expression of sirtuin - 1 (SIRT1), a gene responsible for regulating energy within the cells and coordinating cellular functions, was registered four hours after ingesting the meal enriched with sacha inchi oil, and linked to lowered levels of blood sugar measured at the same time.

The results showed that BPS exposure triggered the formation of fat cells at all levels, with higher concentrations doing the worst damage.

Normally, a high concentration of Vitamin C aims at a visible effect, because it tends to operate as a peeling by loosening dead and old cells.