Sentences with phrase «cells by dendritic cells»

Previous studies found that viruses are ferried from infected to healthy cells by dendritic cells, which are cells that can transport germs without becoming infected themselves.

Mechanistic studies showed that IFN increases antitumor immune responses by enhancing antigen presentation to T cells by dendritic cells present in the tumor microenvironment.

Not exact matches

Since dendritic cells have a receptor for CCL21, they manage to sense the direction — by «smelling» the higher concentration of the mediator.

In larger lymphatic vessels, dendritic cells are passively transported by lymph flow.

Yu said the impairment of sensory nerve regeneration in diabetic corneas is due to decreased ciliary neurotrophic factor, as evidenced by the fact that dendritic cells express ciliary neurotrophic factor (CNTF) in normal and healing corneas but decrease in diabetic corneas due to the reduced infiltration of dendritic cells.

Immunologist Ralph Steinman was honored today by the Nobel Committee for his discovery of dendritic cells, a class of immune cells that help rally the body's natural defenses to fight disease.

«A personalised immunotherapy was prepared for each patient by taking a sample of their blood and extracting a particular type of immune cell called dendritic cells.

«It's very clear that ZOTEN facilitates the development of immunity by holding the virus and letting the dendritic cells get to it,» Shukla said.

Tanyi and colleagues made each patient's vaccine by sifting through the patient's own peripheral blood mononuclear cells for suitable precursor cells, and then growing these, in the lab, into a large population of dendritic cells.

The latter can be primed in tissue culture by providing small numbers of dendritic cells.

Since a primary function of the dendritic cells is to present an antigen to T - cells, to activate the T - cells and begin the immune response, the researchers suspected that T - cell activation in the heart tissue, and perhaps heart - tissue injury caused by T - cells, might be central to the pathological heart enlargement that is called remodeling.

Writing in 2014 in the European Journal of Neuroscience, Leuner and colleagues reported that in rats with symptoms of postpartum depression (induced by stress during pregnancy, a major risk factor for postpartum depression in women), nerve cells in the nucleus accumbens atrophied and showed fewer protrusions called dendritic spines — suggesting weaker connections to surrounding nerve cells compared with healthy rats.

Antigen - presenting cells (APCs), such as dendritic cells and macrophages, activate T cells by engaging protein receptors on the T cell surface.

TB is known for trying to block activation of T cells by infected dendritic cells, two kinds of which are primarily involved in fighting infection: dendritic cells that migrate from the lungs to the lymph nodes, and those that already reside in the lymph nodes.

Because the antigens were the only possible source of TB exposure, Dr. Srivastava says, antigen transfer from infected dendritic cells had to be the avenue for their absorption by other immune system cells in the lymph nodes.

In additional experiments, the NYU team showed that the TB - transporting dendritic cells had to first pass through the lungs — as would be expected in the natural course of the disease that is passed by someone breathing in infected droplets — before heading to the lymph nodes to elicit a strong immune response.

«Although right now we are focusing on developing a cancer vaccine, in the future we could be able to manipulate which type of dendritic cells or other types of immune cells are recruited to the 3D scaffold by using different kinds of cytokines released from the MSRs,» said co-lead author Aileen Li, a graduate student pursuing her Ph.D. in bioengineering at Harvard SEAS.

In a report to be published in the journal Cell Host & Microbe online June 11, researchers showed that immune - system - triggering TB proteins, or antigens, were able to prompt a larger, prolonged immune system response just by being transported from infected dendritic cells to uninfected ones.

«Our study shows a whole new route, or bypass mechanism, for triggering the body's adaptive immune response to TB infection, a means by which infected dendritic cells cooperate with uninfected dendritic cells to activate T cells and respond to the infection,» says infectious disease specialist and study senior investigator Joel Ernst, MD, a professor at NYU Langone Medical Center.

Moffitt researchers wanted to determine if it would be possible to activate the cancer - fighting properties of T cells indirectly by targeting another type of immune cell called a dendritic cell.

One is the «spine pruning theory,» supported by the observation that the frontal brain regions of people with schizophrenia have fewer dendritic spines, the tentacles on the receiving ends of neurons that process signals from other cells.

Antibodies only bind to target cells Peptide antibodies developed by Kwak and co-discoverer, Hong Qin, Ph.D., assistant professor of Lymphoma / Myeloma, wipe out MDSCs in the blood, spleen and tumor cells of mice without binding to other white blood cells or dendritic cells involved in immune response.

Duke scientist are learning more about the process in which melanoma cells hijack dendritic cells, allowing cancer to avoid detection by the immune system.

In a 2009 paper published in Nature Materials, Mooney demonstrated that this could be achieved by loading a porous scaffold — about the size of a dime — with tumor antigen as well as a combination of biological and chemical components meant to attract and activate dendritic cells.

One way to do this is by manipulating dendritic cells, the coordinators of immune system behavior.

The current study found that Tregs have their effect by keeping a second cell type, dendritic cells, from activating a third cell type, CD8 + T cells, which would otherwise kill cancer cells.

T cell activation by dendritic cells takes a long time, he says; anthrax kills so fast that it's questionable whether the microbes would even profit from blocking this system.

In vitro experiments indicated that the antihistamines work by suppressing the accumulation and function of dendritic cells, which take up peanut protein and present it to T cells of the immune system.

The team found that inflammatory damage in the heart can not occur without the help of macrophages and dendritic cells made by the spleen, and that heart failure is to some degree an autoimmune disease.

In this study, published in the journal Cell Reports, and led by Dr. Esteban Ballestar (IDIBELL), the comparison of the epigenetic profiles between dendritic cells and myeloid - derived suppressor cells has allowed them to identify the existence of specific epigenetic alterations that associated with the development of myeloid - derived suppressor cells as a result of exposure to prostaglandin E2.

In another set of experiments, the researchers found that fetal dendritic cells could block the production of TNF - alpha by adult T cells as well.

Carriage of HIV - 1 by dendritic cells may facilitate the lysis and loss of antigen specific CD4 + T cells in acquired immunodeficiency syndrome.

The research team selectively overexpressed a transcription factor, Klf9, only in older neurons in mice, which eliminated more than one - fifth of their dendritic spines, increased the number of new neurons that integrated into the hippocampus circuitry by two-fold, and activated neural stem cells.

Innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high - level IL - 12 secretion by dendritic cells.

Toll - like receptor 9 - dependent and - independent dendritic cell activation by chromatin — immunoglobulin G complexes.

By analyzing the role of PPARγ in dendritic cells using molecular, genomic, and pharmacologic approaches, we identified genes and gene networks regulated by this receptoBy analyzing the role of PPARγ in dendritic cells using molecular, genomic, and pharmacologic approaches, we identified genes and gene networks regulated by this receptoby this receptor.

Kobuka S, Kremers GJ, Cobb JG, Baheza R, Xie JP, Kuley A, Zhu M, Pham W. Induction of Antitumor Immunity by Dendritic Cells Loaded with Membrane Translocating MUCIN - 1 Peptide Antigen.

Ralph M. Steinman, Gerold Schuler, and colleagues find that large numbers of dendritic cells can be mobilized by specific cytokines from progenitors in the blood stream.

When stimulated by immunization, they migrated to different areas in the spleen: the 33D1 dendritic cells into the CD4 + T cell area and the XCR1 dendritic cells to the CD8 + T cell area.

Sequence - specific potent induction of IFN - α by short interfering RNA in plasmacytoid dendritic cells through TLR7.

Selective contribution of IFN - α / β signaling to the maturation of dendritic cells induced by double - stranded RNA or viral infection.

Tracking The Migration of Dendritic Cells By In Vivo Optical Imaging.

One of these checkpoints is antigen presentation, which is accomplished primarily by mature dendritic cells.»

Antonio Lanzavecchia finds that efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte / macrophage colony - stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

This mechanism allows dendritic cells to respond to altered lipid homeostasis by changing gene expression and immunophenotype.

By showing that ligands associated with innate immunity enable dendritic cells to initiate T cell responses, this work provided the key missing link between the innate and adaptive immune responses.

Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin — radixin — moesin (ERM) proteins.

Regulation of STAT signaling in mouse bone marrow derived dendritic cells by respiratory syncytial virus.

By integrating the sequence data and the associated metadata, we have established laboratory and bioinformatics - based methods that enable us to investigate scientific questions including: the tropism of ZIKV for dendritic cells and the antiviral response of the cells during infection (Bowen et al. 2017); investigating the phylogenetic diversity of strains obtained by Biodefense and Emerging Infections (BEI) Resources and distributed to virologists (manuscript in preparation); the genetic determinants of ZIKV host adaptation in C6 / 36 mosquito vs. Vero cells; and the diversity of ZIKV circulating in limited geographic regions, including Barbados, Colombia, and the state of Chiapas, MexicBy integrating the sequence data and the associated metadata, we have established laboratory and bioinformatics - based methods that enable us to investigate scientific questions including: the tropism of ZIKV for dendritic cells and the antiviral response of the cells during infection (Bowen et al. 2017); investigating the phylogenetic diversity of strains obtained by Biodefense and Emerging Infections (BEI) Resources and distributed to virologists (manuscript in preparation); the genetic determinants of ZIKV host adaptation in C6 / 36 mosquito vs. Vero cells; and the diversity of ZIKV circulating in limited geographic regions, including Barbados, Colombia, and the state of Chiapas, Mexicby Biodefense and Emerging Infections (BEI) Resources and distributed to virologists (manuscript in preparation); the genetic determinants of ZIKV host adaptation in C6 / 36 mosquito vs. Vero cells; and the diversity of ZIKV circulating in limited geographic regions, including Barbados, Colombia, and the state of Chiapas, Mexico.

When activated by VTX - 2337, TLR - 8 prompts dendritic cells within tumors to secrete factors that fuel a cascade of immune responses.