Chronic oxidative stress — meaning chronic presence over overly reactive oxygen - containing molecules and cumulative damage to
our cells by these molecules — is a risk factor for development of most cancer types.
Not exact matches
The theory developed that perhaps lightning struck a pond of water causing several
molecules to combine in a random way which
by chance resulted in a living
cell.
Molecular biology, contrary to the article, does not support evolution
by natural chance because evolution can not occur without inheritance, inheritance can not occur without DNA and DNA is so complex it could not have evolved
by chance unless we are to assume that
molecules just happened to arrange themselves into the DNA
molecule at the same times as a nucleus formed to hold the DNA, at the same time as the
cell membrane just happened to form around it, at the sametime as all the
cell maintaining process in the cytoplasm just happened to come into existence to form a single
cell and that all these aspects just happened to come together and work harmoniously.
Scientific reductionism, however, wants to reduce biology to physics and chemistry, to explain the properties of «life»,
by thorough specification of the particulars (atoms and
molecules) that are integrated into
cells and organisms.
Biology can be designated as a science logically distinct from physics and chemistry because its heuristic field is constituted
by questions directed toward whole organisms (plants and animals),
cells and their «achievements» rather than toward atoms and
molecules as such.
Thus, at the lowest level, electrons tend to unite and converge in the atom; atoms converge
by molecularization, crystallization;
molecules unite
by polymerization;
cells unite
by conjugation, reproduction, association; nerve ganglions concentrate and localize to form a brain
by what might be called a process of cephalization; the higher animal groups form colonies, hives, herds, societies, etc.; man socializes and forms civilizations as foci of attraction and organization.
First x object was created out of nothing, then combined with other things created out of nothing, then magically an atom, yhen a
cell, a
molecule, then bacteria, single
cell creatures, followed
by simple sea creatures with organs, then more advanced creatures, next red blooded mammals, then primates, and finally human.
One may then generalize this intuition and, employing the criterion of «active singularity,» further argue
by analogy that whatever is experienced to act as one must also feel as one, whether this be an animal or a
cell, a
molecule or an atom (1970a, 36, 143f.
The chemical environment of the
molecule and the
molecule itself are in constant, dynamic interaction, influenced
by the magnitude of physical forces and configuration of chemicals within the
cell.
«What we have described as globalization is remarkably close to Teilhard de Chardin's planetization, in which «[mankind, born on this planet and spread over its entire surface, come [s] gradually to form round its earthly matrix, a single, major, organic unity, enclosed upon itself.4 Thus the globalization of humankind could lead to the formation of a new kind of living entity — a social organism — on the same cosmic principle as that
by which atoms join to form
molecules,
molecules join to form mega-
molecules, mega-
molecules unite to form living
cells, and innumerable
cells constitute an organism.
Mutations are indeed not, so far as we know, selected
by any overall purpose favoring evolution; but this is compatible with there being short - run and very naive purposes, desires, or feelings in the atoms and
molecules constituting the genes, as well as in every
cell and every metazoan with a nervous system.
RS: According to the hypothesis of formative causation, outlined in my book A New Science of Life, systems such as
molecules, crystals,
cells, organs and organisms are organized
by specific morphogenetic fields, which give them their characteristic form and organization.
As one moves up levels of organization — electrons, atoms,
molecules,
cells, and so on — the properties of each larger whole are given, not merely
by the units of which it is composed, but
by the new relations among these units.
Waddington's paper in Towards a Theoretical Biology follows on from one
by Brian Goodwin («A Statistical Mechanics of Temporal Organization in
Cells») in which Goodwin looks at the question of how ordered systems like cells, and still more macro-organisms, supervene on the movements of their constituent molecules, and how one is to close the gap between molecular biology and cell physio
Cells») in which Goodwin looks at the question of how ordered systems like
cells, and still more macro-organisms, supervene on the movements of their constituent molecules, and how one is to close the gap between molecular biology and cell physio
cells, and still more macro-organisms, supervene on the movements of their constituent
molecules, and how one is to close the gap between molecular biology and
cell physiology.
The objects of his study range from a class of
molecules that have the basic self - duplicating property of living things, through
cells which suggest purely physical systems, through animals which give increasing evidence of having minds, to human beings in whom streams of consciousness seem to involve continual choices of action, at the opposite pole from control
by impersonal laws of nature.
Spontaneous self - organization is invoked
by biochemists in the evolution of the prebiotic world in which a variety of atoms assembled into organic
molecules eventually giving rise to
molecules of RNA, DNA and proteins which led to further complex assemblies and eventually to
cells.
Lewontin, Rose and Kamin discuss the different levels at which atoms assemble to make
molecules,
molecules assemble to make
cells and so on: «as one moves up a level the properties of each larger whole are given not merely
by the units of which it is composed but of the organizing relations between them... these organizing relationships mean that the properties of matter relevant at one level are just inapplicable at other levels» (NG 278).
The good ecologist goes further
by taking into account the fact that organisms (including
cells and
molecules) are not simply at the mercy of the environment they happen to be in.
«It felt like my body stubbornly clung to each and every last fat
molecule in my
cells as if they were all that stood between my baby and a miserable, slow death
by starvation.»
The hCG (human chorionic gonadotropin) hormone is a remarkable
molecule, which is very unusual because it is produced only
by the
cells that will become the placenta of the developing embryo (trophoblast
cells).
These
molecules are absorbed
by your blood, and when they get close to the breast they are transported into the milk making
cells of the breast via diffusion.
The
molecule — called VCP — is a component of the infected
cell rather than a substance produced
by the virus itself.
The new study suggests that MDR1 is responsible for protecting TH17
cells in the gut from bile acids — detergent - like
molecules produced
by the liver that break down fats.
This type of sensor also glows in the presence of
molecules secreted
by E. coli, so the material doesn't have to be in direct contact with bacterial
cells to flag food contamination.
Imai and Stein also found they could prevent the loss of the neural stem
cells missing Nampt
by giving the mice NMN, the next
molecule in the chain of events leading to NAD.
Researchers found that NAD +, a natural
molecule found in living
cells, plants and food protects against autoimmune diseases
by altering the immune response and turning «destructive»
cells into «protective»
cells.
The protein expressed
by the gene is thought to bind to serotonin receptor
molecules and ferry them to the
cell surface, positioning them to receive serotonin's signals from neighboring
cells.
«Since this is a natural
molecule found in all living
cells, including our body, we hope that it will be well - tolerated
by patients,» said ElKhal.
A viral epitope inserted into the complementarity - determining region 3 (CDR3) loop of the heavy chain of a self immunoglobulin (Ig)
molecule was generated from the Ig context and was presented
by I - Ed class II
molecules to virus - specific, CD4 + T
cells.
It is emerging that the chemical structure of RNA
molecules is extensively modified
by specific enzymes normally present in our
cells, which are commonly found to be altered in severe medical syndromes and various types of cancers.
«We have found that the bone marrow production of immune
cells is affected
by high blood sugar and have identified a possible
molecule mediating this effect.
Now 24, he is a first - year graduate student in the department of cellular and structural biology at the University of Texas Health Science Center in San Antonio (UTHSCSA), where he is studying the role of oxidative damage — the wear and tear inflicted upon the
cell by toxic
molecules called free radicals — in the aging process.
«It binds highly affine and very specific to sugar
molecules that sit in the
cell wall of the fungi and which are normally recognized as «foreign»
by the plant,» explains Professor of Molecular Biology Alga Zuccaro from the University of Cologne.
Fischetti and his colleagues used a phage - encoded
molecule to identify a bacterial target enzyme called 2 - epimerase, which is used
by Bacillus anthracis to synthesize an essential
cell wall structure.
A class of small
molecules found in grapes, red wine, olive oil, and other foods extends the life of yeast
cells by approximately 70 % and activates genes known to extend life span in laboratory animals.
The experiments included sorting immune
cells found at injury sites
by molecules on their cellular surfaces, and many hours looking at mouse
cells through the microscope.
But it's only because it's on the microscopic level that this structure can overcome the problem of maintenance: the
molecules that control the wheel and axle reach it
by diffusing through the
cell's cytoplasm.
Led
by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern of
molecules called microRNA (miRNA) in tumor
cells might predict patients» response to radiation therapy.
The drug lowers blood pressure
by altering the flow of calcium
molecules in and out of
cells.
Thus, transport of peptide — MHC II complexes
by DCs not only accomplishes transfer from late endocytic compartments to the plasma membrane, but does so in a manner that selectively concentrates TCR ligands and costimulatory
molecules for T
cell contact.
Targeted cancer treatments are designed to attack
molecules produced
by mutations, but if the targeted mutation occurs on an evolutionary branch and not the trunk, the treatment will fail as other branches dominate and treatment resistant
cells spread.
«That upheld our hypothesis, which was that biochar could interfere with
cell signaling, most likely
by binding with the fatty - acid
molecules that the speakers were using to broadcast their message.»
Now research in rodents suggests that gut microbes may alter the inventory of microRNAs —
molecules that help keep
cells in working order
by managing protein production — in brain regions involved in controlling anxiety.
A panel of small
molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human
cell types, was discovered
by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Loss of LKB1
by regulatory T
cells was also associated with increased levels of signaling
molecules or cytokines associated with the Th2 immune response, Kai said.
Because of their importance in
cells, fatty acids» functions and metabolism, or breakdown have been widely studied
by biologists, but the standard techniques makes it difficult to visualize precisely where these
molecules are located within the
cells.
Designing
molecules that selectively target thiols produced
by cancer
cells that cause drug resistance is the focus of many years» work
by Dimmock, Das and their collaborators.
Therefore, having less MHC I
molecules may allow cancer
cells to hide better and escape detection
by the immune system.
Varghese and her team showed that they could control the differentiation of human pluripotent stem
cells into functional osteoblasts — bone - building
cells — simply
by adding the
molecule adenosine to their growth medium.
The BPEC
cell developed
by the researchers is based on the naturally occurring process of photosynthesis in plants, in which light drives electrons that produce storable chemical energetic
molecules, that are the fuels of all
cells in the animal and plant worlds.