Sentences with phrase «cells change from»

The cortex cells change from a round into a flattened appearance.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Many of these mutants are likely non-viable; however, many will have subtle changes to their functional components, including the HA gene which allows the virus to bind host cells, and NA gene which allows the virus to escape from host cells.

The evolutionary, ecological perspective insists that we are, in the most profound way, «not our own»: we belong, from the cells of our bodies to the finest creations of our minds, to the intricate, ever - changing cosmos.

Thus, the transition from instinct to reason results in the radical transformation of the animal into man; matter as it evolves toward the cell becomes radically transformed into living matter; and vegetative life becomes qualitatively changed into conscious life.

... yeah suzy and others... I just happen to realize that when monkey devolving didn't quite work out on paper it all changed to single cells and from the slime off of the worlds garbage can and so on... I just happen to know more than you think... In another ten or twenty years the science books will all have a new teaching... the Bible has been around and hasn't changed one word in over two thousnad years..

A clump of cells with no brain, and no neural tube is no more «a human life» than cells from your skin layer, or a sperm cell with no change of fertilizing an egg.

(Cf. the phenomenon of the «runners» at first connected with the mother plant and then separated from it; the fluid transition between various plants and animals which appear to be one; the germ - cell inside and outside the parent organism, etc.) Living forms which present what are apparently very great differences in space and time can ontologically have the same morphological principle, so that enormous differences of external form can derive from the material substratum and chance patterns of circumstance without change of substantial form (caterpillar - chrysalis butterfly).

Random mutation allows cells to escape from the engineered change.

Such was the comfortable vista which, less than a century ago, began abruptly to change beneath our gaze, something in the fashion of those organic tissues in the living body which, after long remaining harmless and dormant, their cells apparently indistinguishable from those of the surrounding tissue, suddenly burst into dangerous growth.

We belong, from the cells of our bodies to the finest creations of our minds, to the intricate, ever changing cosmos.

Under Child's theory there is complete continuity from the reaction of the cell with its environment, which constitutes the primary metabolic gradient, and from the later reactions, by which the pattern of the developing embryo is laid down in accordance with the changing gradient pattern, to the intellectual processes by which the adult organism adjusts its relations to the outside world.

Instone - Brewer's own narrowing of the question of individual life -LRB-»... when does an embryo change from being a bundle of undifferentiated cells into a living human individual?»)

Ecological perspective insists that we are in the most profound ways, «not our own» we belong from the cells of our bodies to the finest creation of our minds, to the intricate, constantly changing cosmos.

Extracts from this garlic even protected cells in a laboratory dish from certain types of damage.13 This isn't really surprising when you consider the nutritional changes that typically occur in plants when they sprout.

This module is developed for customers that want the benefits from using Eilersen digital load cells but can not change existing equipment designed for analog strain gage load cells [more]

During intense or extensive exertion, the sickle hemoglobin can change the shape of red blood cells from round to quarter - moon, or «sickle.»

I was coming onto the highway from the on - ramp and some jack - ass woman on her cell phone driving a red sporty car couldn't be bothered to slow down or change lanes to let me in.

Change has come fast in 50 years — from the mop to electrical gadgets, cell phones, ipods, computers, blackberries, and internet.

It has an easy - to - access pocket, holder or pouch for everything from bottles, diapers, wipes, a change of clothes, cell phone, keys, laptop.

A breast biopsy involves the removal of a small tissue sample from the breast for lab testing to determine if any cancerous cell changes are present.

Some of these changes happen in the final weeks of pregnancy, including the stage when red blood cell production is transferred from the liver to the bone marrow.

Scientists must seek a new, more energetic engagement with Americans if they are to overcome public skepticism on issues ranging from climate change to stem cell research, AAAS CEO Alan I. Leshner writes in a commentary in The Chronicle of Higher Education.

The Cincinnati Children's team suspects that the EBNA2 transcription factor from EBV is helping change how infected B cells operate, and how the body responds to those infected cells.

When Stein eliminated Nampt from neural stem cells, several significant changes took place.

Many of the mutations in ASD, Yan explained, result from chromatin remodeling factors, which are involved in dynamically changing the structure of chromatin, the complex of genetic material in the cell nucleus that condenses into chromosomes.

Faced with an often - hostile Congress, Obama enacted many of his signature policies by executive order — from reversing restrictions on research with human embryonic stem cells to helping communities prepare for climate change.

The cell membranes changed from green fluorescent to a faint red glow, which indicates damage.

Other researchers have tried changing cell behavior by creating protein switches from scratch, but Lim's approach — mixing and matching naturally existing proteins — may be more versatile and practical: «It can be useful as a biotechnology device or for repairing cells in humans.

Dr. Lobo said that this latest research could help researchers better understand changes in brain cells and mitochondria from other addictive disorders.

«By the use of high magnification we show that the skin cells suffer from shrinkage and therefore change their surface.

Now Bruce Spiegelman at the Dana - Farber Cancer Institute in Boston and colleagues have shown that foreskin cells from mice can be changed into brown fat cells.

As the heart starts pumping a primitive blood - like fluid around the body of an embryo, the change in pressure from the flowing liquid is the cue for cells lining the aorta to change first into blood stem cells, then into all blood - cell types in the body.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

«This reflects how cells do not like to change from one specialized cell type to another and resist a change in cell identity,» said Pasque.

«This is the first study, to our knowledge, that demonstrates the mechanical continuity, strain transfer, and conformational changes that result from chemical energy release from the atomic scale up through the whole - cell level, as well as how tensegrity guides those changes to drive cellular movement,» says Ingber.

They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.

Somewhere along the way, certain molecular changes, including a deletion of 29 base pairs from the original virus, allowed SARS to infect and replicate in human cells.

Electromagnetic signals from cell phones can change your brainwaves and behavior.

Previous work from Shenoy's group has shown that the relationship between cancer cells and the extracellular matrix is dynamic, containing feedback mechanisms that can change the ECM's properties, including overall stiffness.

Bowel cancer, also called colorectal cancer, results from a series of genetic changes (mutations) that cause healthy cells to become progressively cancerous, first forming early tumors called polyps that can eventually become malignant.

Preliminary data from another study of theirs suggest that Fresno youth, by moving elsewhere to attend college, might see a reversal of some epigenetic changes to their immune cells.

The cells from the ovaries, on the other hand, showed no change in their production of the hormones progesterone and oestradiol.

The detector developed at UNH, known as DoSEN, short for Dose Spectra from Energetic Particles and Neutrons, measures and calculates the absorbed dose in matter and tissue resulting from the exposure to indirect and direct ionizing radiation, which can change cells at the atomic level and lead to irreparable damage.

Analyzing tissue specimens from 10 people with stomach cancer, the researchers found evidence that those same mature cells in the stomach also had reverted to a stem cell - like state and had begun to change and divide rapidly.

The researchers discovered that two members of a class of ion channels that can sense a change in temperature were present in neural crest cells from chickens and mice.

Almost all of these pathways work by protein handshakes — one protein «talking» to another in order to, for example, encourage the import of a needed nutrient, to block a compound from accumulating to a toxic level, or to alert the cell's interior to changes in the outside environment.

One would culture thin sheets of meat, seeded by cells from a living animal, on a reusable polymer scaffold; the other would grow meat on small edible beads that stretch with changes in temperature.

By analyzing chemical changes of the IRS - 2 protein in immortalized cultures of human white blood cells, it determined that IRS - 2 appeared in two different forms — «on,» which allows the signal to pass through, and «off,» which stops the signal from activating the cells into M2 macrophages.

Sen and his colleagues tested sucralose, a popular low - calorie sweetener, on stem cells — cells that could change into mature fat, muscle, cartilage or bone cells — taken from human fat tissue.