When progranulin levels are low, brain
cells die more readily when exposed to toxins.
Not exact matches
One reason that taller people are
more likely to
die of many types of cancer is because they tend to have bigger organs, so there is a greater chance that one
cell in the organ will become cancerous, Batty said.
Because actual children — you know, the ones that are
more than just a collection of
cells, have an actual nervous system, and are outside the womb, wouldn't have to
die of starvation if the money that went to that Lexus SUV went instead to a charity?
That includes three settlements of $ 1 million or
more with families of inmates who
died on Rikers Island, including Jerome Murdough, who
died in an overheated
cell and whose case Mr. Stringer settled.
In experiments with mice, the researchers found that Paneth
cells engineered to lack a functional ATG16L1 gene were five times
more likely to
die in the face of rising TNF - alpha signals than normal
cells.
«
More women are postponing childbearing, but with age, the cumulus
cells that surround and nurture the eggs begin
dying; we've found that this is caused by lack of oxygen,» said senior author Pasquale Patrizio, M.D., director of the Yale Fertility Center and professor in the Department of Obstetrics, Gynecology & Reproductive Sciences.
The trimer - expressing
cells even
died more quickly than
cells expressing mutant forms of SOD1 that are found in severe hereditary ALS cases.
They found — as they did in the 2016 study — that when these
cells expressed SOD1 mutants that predominantly form trimers, the
cells died much
more quickly than control
cells containing normal SOD1.
When RCGD 423 was applied to joint cartilage
cells in the laboratory, the
cells proliferated
more and
died less, and when injected into the knees of rats with damaged cartilage, the animals could
more effectively heal their injuries.
Svendsen is
more optimistic about his team's work involving human tests of a novel stem
cell approach to treat ALS, a degenerative motor neuron disease in which
cells that transmit messages from the brain and spinal cord to the muscles wither or
die.
Buds went missing because mature taste bud
cells died off
more quickly, and fewer new
cells developed to take their place.
Brains of people who
died from various diseases caused by tangled tau had
more dead and damaged
cells if the people carried APOE4.
In fact,
more than 80 percent of their tumor
cells were
dying, the researchers reported.
They were also five to 10 times
more likely to wither and
die than unexposed
cells even if the vapour contained no nicotine, the addictive ingredient in conventional and most electronic cigarettes.
This led to a gradual increase in Spo0A activity as opposed to a spike, and such
cells were several times
more likely to fail or
die during sporulation.
While the patient eventually relapsed and
died more than a year after CAR T -
cell therapy, the brain tumor never recurred.
Researchers used the new therapy to inhibit a pathway in the cancer
cells known as mTOR signaling — putting the brakes on this pathway, combined with the current standard therapy, caused
more of the cancer
cells to
die.
In the course of the inflammatory process, the liver
cells (hepatocytes)
die more frequently due to programmed
cell death.
Without the Werner protein, the
cells in the body
die sooner, and you age
more rapidly.»
More recently, however, researchers have suggested that macrophages — specialized immune
cells that reside in the dermis — are attracted to the wound inflicted by the tattoo needle and gobble up the tattoo pigment just as they would normally engulf an invading pathogen or piece of a
dying cell.
Too little and
cells die much
more frequently.
A
more attainable goal may be regenerative tissue transplants, for example, replacing
dying liver
cells in someone with early - stage liver disease with chunks of healthy stem
cells from a personalized liver organoid.
When retinal
cells die they are much
more likely to
die in the center of the retina than in the periphery, which the researchers say is exactly what happens in humans with age and the problem with macular degeneration.
One of them was used to reproduce acquired aplastic anemia: due to various types of damage, some of the stem
cells die, and those that remain need to divide
more frequently in order to maintain the production of blood
cells; as a result of so many divisions, the telomeres shorten and the disease appears.
In healthy human
cells, the p53 protein helps prevent tumors by putting the brakes on the
cell cycle to give an ailing
cell time to fix itself — or
die — rather than spawning
more corrupted
cells.
In the first large study to look at how blood transfusions from previously pregnant women affect recipients» health, researchers discovered men under 50 were 1.5 times
more likely to
die in the three years following a transfusion if they received a red blood
cell transfusion from a woman donor who had ever been pregnant.
Since tumor
cells typically use NADPH to protect themselves from toxins, the
more NADPH they synthesize for protection, the faster they
die.»
Cells are programmed to
die: Fifty or sixty genes, maybe
more, regulate their expiration.
It is still not entirely clear whether the cancer
cells migrate directly through the resulting gap in the vascular wall or whether there is an indirect effect: «We have evidence that many
more molecules are released when the vascular wall
cell dies and that they render the surrounding area
more permeable to cancer
cells,» says Offermanns.
Rattan joined the Clark group in 1984 and started exploring what happens when skin, bone, and connective tissue
cells grow old and enter a state of limbo — called senescence — in which they neither divide nor die (see «More Than a Sum of Our Cells&raq
cells grow old and enter a state of limbo — called senescence — in which they neither divide nor
die (see «
More Than a Sum of Our
Cells&raq
Cells»).
Previous attempts to maintain cultures of the so - called nephron progenitor
cells often failed, as the
cells died or gradually lost their developmental potential rather than staying in a
more medically useful precursor state.
One of the paper's co-authors, Hugh Willison, who studies GBS at the University of Glasgow in Scotland, says it's possible that something
more subtle is happening: Like other viruses, the one that causes Zika hijacks a
cell's own replication machinery to make new copies of itself, which then break out of the
dying cell and infect neighboring
cells.
When tested in laboratory samples of leukemia
cells and in animals with human - like leukemia, the approach caused cancer
cells to
die much
more quickly than with conventional targeted therapies.
Ever since Antonie van Leeuwenhoek peered through his crude microscope and confirmed that life is indeed packaged in very small containers, biologists have recruited physicists to focus stronger lenses, train
more powerful rays and run ever tinier probes on
cells and the molecules that make them live — and
die.
The third treatment regimen — NMD - inhibiting compound followed by doxorubicin — was the most effective:
cells were two - and - a-half times
more likely to
die compared to doxorubicin alone.
When the brain is harmed by injury or disease, neurons often
die or degenerate, but glial
cells become
more branched and numerous.
When Lin engineered the telomerase - expressing hepatocytes to
die in response to a chemical signal and gave the mice with a liver - damaging chemical, he found that those animals in which the telomerase
cells had been killed exhibited much
more severe liver scarring than those in which the
cells were functional.
The virus selectively infects
cells that form the brain's cortex, or outer layer, making them
more likely to
die and less likely to divide normally and make new brain
cells.
Its assault made those
cells more likely to
die and less likely to divide normally and make new brain
cells.
They used yeast
cells to model the disease, which allowed them to look at over 5,000 genes to map out which ones caused
more or fewer
cells to
die.
As tumors proliferate, they often outgrow their blood supply so that many
cells die, sending
more PS into circulation.
The goal is to understand why some cancer
cells more or less lie dormant, while others grow aggressively and why do some cancer
cells die from chemotherapy, while others spread unhindered despite treatment.
Included among the numerous recipients of Mr. Sanford's gifts, that total
more than one billion dollars, are: the Edith Sanford Foundation for Breast Cancer that was created in 2012 by a gift of $ 100 million in honor of Mr. Sanford's mother who
died of breast cancer when he was four years old; the Sioux Valley Hospitals and Health System, which renamed itself Sanford Health in 2007, in recognition of a $ 400 million gift; a $ 125 million gift in 2014 to establish Sanford Imagenetics, a program that will integrate genomic medicine into primary care for adults; the University of California San Diego which received a $ 100 million gift for the creation of the Sanford Stem
Cell Clinical Center in 2013 to accelerate the translation of stem cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Medic
Cell Clinical Center in 2013 to accelerate the translation of stem
cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Medic
cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Medicine.
The researchers hypothesize that in older people, many of the
cell lineages in the blood have reached their maximum number of
cell divisions and
died off, leaving the ones that have divided
more slowly and, therefore, have accumulated fewer mutations.
An abnormal mass of tissue that results when
cells divide
more than they should or do not
die when they should.
Greene told The Scientist that these «bystander»
cells are not active enough to facilitate viral replication; they typically
die off without producing
more HIV.
As Parkinson's progresses,
more dopamine - producing brain
cells die.
Self - renewal, the ability of a stem
cell to divide repeatedly, is crucial to perpetuate a pool of pluripotent
cells that can differentiate to supplant
cells that
die during the lifespan of... >>
MORE
One of them was used to reproduce acquired aplastic anaemia: due to various types of damage, some of the stem
cells die, and those that remain need to divide
more frequently in order to maintain the production of blood
cells; as a result of so many divisions, the telomeres shorten and the disease appears.
«The final live - or -
die moment in the
cell's life has
more to do with the composition of the proteins in its
cell than the loss of the chromosome.»