Researchers in the Departments of Biomedicine and Nephrology at the University Hospital and the University of Basel have discovered that the immune system uses a molecular biological clock to target intolerant T
cells during their maturation process.
Not exact matches
In order to locate all gene switches, the Freiburg research team used modern sequencing methods to examine the entire genome — DNA, epigenetic markers and RNA —
during the development,
maturation and disease of human cardiac muscle
cells.
During their
maturation process, T
cells in the thymus undergo various tests requiring T
cell's antigen receptor to bind the body's own molecules.
Their findings outlined four distinct cellular phases of sperm stem
cells maturation, revealing how the stem
cells progress from a «quiescent» state, to a «proliferation» state
during which stem
cells divide, to a final «differentiation» state when stem
cells mature to become sperm.
In order to locate all gene switches, the Freiburg research team used modern sequencing methods to examine the entire genome - DNA, epigenetic markers and RNA -
during the development,
maturation and disease of human cardiac muscle
cells.
LOCATING PRE-HEMATOPOIETIC STEM
CELLS Researcher: Fuchou Tang, Assistant Professor, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University Project: In a study published in Nature, Tang and his collaborators isolated pre-hematopoietic stem cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their maturation into HSCs (533:487 - 92, 2
CELLS Researcher: Fuchou Tang, Assistant Professor, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University Project: In a study published in Nature, Tang and his collaborators isolated pre-hematopoietic stem
cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their maturation into HSCs (533:487 - 92, 2
cells (HSCs) for the first time and showed their unique transcriptome signatures before and
during their
maturation into HSCs (533:487 - 92, 2016).
Flavio Donato's work has revealed that,
during development, stellate
cells in the medial entorhinal cortex are the source of an activity - dependent instructive signal necessary for the
maturation of those neurons that give us a sense of where we are.
In the thymus, expression of CD4 and CD8 varies
during T
cell maturation, such that
cells initially do not express CD4 or CD8 (double negative [DN]-RRB- after arriving to the thymus, then express both CD4 and CD8 (double positive [DP]-RRB- after TCR rearrangement, and finally downregulate either CD4 or CD8 to generate mature single - positive
cells that exit into the periphery.
Non-cardiomyocytes influence the electrophysiological
maturation of human embryonic stem
cell - derived cardiomyocytes
during differentiation.