Sentences with phrase «cells engineered in»

Mapping the expression profiles of all genes one cell at a time revealed unexpected heterogeneity in the stem cell - derived lung cells, and the research team at the CReM used this information to improve the airway cells engineered in the lab.

In a boon to stem cell research and regenerative medicine, scientists at Boston Children's Hospital, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Boston University have created a computer algorithm called CellNet as a «roadmap» for cell and tissue engineering, to ensure that cells engineered in the lab have the same favorable properties as cells in our own bodies.

Unmatched performance — high transfection efficiency & cell viability in primary cells Fully scalable — from R&D to the clinic without reoptimization Safe — non-viral cell engineering in closed, sterile, computer - controlled environment Cell loading flexibility — mRNA, gRNA, siRNA, DNA, proteins, cell lysates, and small molecules into autologous or allogenic immune, stem / progenitor, or somatic cells Regulatory ease — Master File designation with the CBER Division of the U.S. FDA, cleared by NIH's RAC and Health Canada, cGMP - compliant, and CE - marked

Not exact matches

When Vancouver civil engineer James Dean started his greentech company, dPoint Technologies, in the early 2000s, he figured he could hitch his wagon to the promise of the hydrogen fuel cell sector.

One day in 2005, video - software engineer and entrepreneur Ted Schilowitz's cell phone rang.

Technology by Cellectis allows cellular engineering, and a human trial of the company's work in editing blood cells will be presented at the upcoming American Society of Hematology.

He earned degrees in cell biology and tissue engineering and eventually got a job in a lab run by Vladimir Mironov, who was investigating the use of bioprinting — 3 - D printing using living cells — to generate replacement organs.

The squeeze system Sharei then designed to temporarily disrupt cell membranes — for which he's been granted most of his 10 patents — is the basis for SQZ Biotech, the company he co-founded in 2013 with the pioneering MIT professors he worked for: Klavs Jensen, the school's head of chemical engineering, and Robert Langer, a renowned bioengineer and serial entrepreneur.

In Brooklyn, Modern Meadow, backed by $ 53 million from investors, creates «leather» using engineered cells rather than animal skins.

But in June, the Chan Zuckerberg Initiative — the philanthropic organization in Palo Alto, California, that funds the Biohub — contributed an undisclosed amount of money and software - engineering support to the Human Cell Atlas data platform, which will be used to store, analyse and browse project data.

In the second half of 2017, the United States Food and Drug Administration (FDA) approved two immunotherapies that use genetically engineered T cells (CAR - T cell therapy) to fight cancer.

We had two entrepreneurs in the cell phone industry, a Business Broker, a Hedge Fund Manager, Managers of a Trust, a Business Appraiser, an Engineer, a Financial Planner, a Bar and Grill Owner, a Computer Software Executive, A Nurse RN, an Equities Analyst, a Wine Vineyard owner, and a former Mortgage Broker.

February 2, 2017 By Ann Perry http://mbd.utoronto.ca/ When Arif Aziz learned last fall about a new independent study project that was bringing together MBA candidates and PhD students in health sciences and engineering to map the global market for stem cell therapies, he jumped at the opportunity.

It houses well - developed test cells where customers can work hand - in - hand with process engineers and technicians to evaluate equipment and processes under controlled, safe, pilot plant conditions.

The Chief of Army Staff, Lt Gen Tukur Yusufu Buratai has inaugurated the Multi — Cell box culvert linking Shema — Bakoshi — Matankari towns in Zuru local government Area of Kebbi State which was constructed by Army Engineers.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellIn experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellin the face of rising TNF - alpha signals than normal cells.

Because the human cells had been genetically engineered to express green fluorescent protein, the tiny blobs showed up in brilliant lime through the transparent window that the scientists glued into the mice's skull.

These experiments were complemented by genetic manipulations in which some mice were engineered to lack a gene known as Tap1, which is crucial for the MHC I complex to make its way to the cell surface.

Carlos Filipe, a chemical engineer at McMaster University in Hamilton, Canada, and colleagues have developed a new kind of flexible film that's coated in molecules that glow when they touch E. coli cells.

An implant of genetically engineered skin cells has been designed to grow darker in colour when it detects early breast, prostate and colon cancers

The implant, made of genetically engineered cells, has been designed to detect developing breast, prostate and colon cancers when they are only a few millimetres in size.

There is an engineering element to thinking about cell circuits that is a natural place for biologists that are interested in more physical chemistry and physical approaches to find a home.

The goal of synthetic biology, which combines biology with engineering, is to (re) program cells in order to improve their performance in a specific task, or so that they can efficiently perform a new task.

Fussenegger created his biological calculator by engineering an embryonic kidney cell to respond to two different chemicals: erythromycin (an antibiotic) and phloretin (a compound found in apple trees).

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body,...

The new technology, described in the journal Molecular Cell, offers a new way to seek drug targets for many diseases, not just Parkinson's, says Timothy Lu, an MIT associate professor of electrical engineering and computer science and of biological engineering.

Some of the other projects involve the development of proton exchange membrane for fuel cell application, a gyroscope based on micro-electromechanical technology and research on innovative engineering materials to fabricate ceramic membranes that can partially oxidize methane to syngas used as feedstock in commercial methanol production.

Now that they've shown it's possible to encode and retrieve information sequentially in bacteria, Shipman hopes to create «molecular recorders» — genetically engineered cells with a time log of their activities.

The discovery, published today in Cell, came about when postdoctoral fellow Akhila Rajan of Harvard Medical School in Boston and her adviser, Norbert Perrimon, engineered flies that lacked a nutrient - sensing protein called Upd2.

The researchers deployed this technology in yeast cells that are genetically engineered to overproduce a protein associated with Parkinson's disease, known as alpha - synuclein.

In an amazing feat of tissue engineering, Anthony Atala and his research team at the Children's Hospital in Boston are creating new organs in the laboratory using patients» own cells and by employing the same technology used to clone Dolly the sheeIn an amazing feat of tissue engineering, Anthony Atala and his research team at the Children's Hospital in Boston are creating new organs in the laboratory using patients» own cells and by employing the same technology used to clone Dolly the sheein Boston are creating new organs in the laboratory using patients» own cells and by employing the same technology used to clone Dolly the sheein the laboratory using patients» own cells and by employing the same technology used to clone Dolly the sheep.

When injected into mice engineered with a tau mutation that makes the protein clump abnormally in brain cells, triggering memory and motor problems, the antibodies reduced the clumping and improved the animals» behavior.

Then, to boost the number of cells, which is another hurdle in tissue engineering, the researchers mixed the chondrocytes with human mesenchymal stem cells from bone marrow.

Cells engineered to produce insulin under the command of a smartphone helped keep blood sugar levels within normal limits in diabetic mice, a new study reports.

Letian Dou, a chemical engineer at Purdue University, and colleagues were only able to form these light - harvesting crystals in their solar cells by cranking the heat to 105 ° Celsius, much hotter than your average sun - blasted window.

Dr. Llovet and colleagues demonstrated that the expression of mutant IDH in the adult liver of genetically engineered mice impairs liver cell development and liver regeneration — a process in which the liver responds to injury — and increases the number of cells to form a tumor.

To solve this problem, Smadar Cohen, a tissue engineer at Ben - Gurion University of the Negev in Beersheba, Israel, and colleagues seeded rat cardiac cells onto scaffolds which they transplanted into the omentums of eight rats.

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

«We concluded that stem cells used in cardiac therapy should be drawn from healthy donors or be better genetically engineered for the patient.»

«By treating with chemotherapy, we're driving cells through a transition state and creating vulnerabilities,» said first author Aaron Goldman, PhD, a postdoctoral fellow in biomedical engineering at BWH.

The engineered cells will circulate and, the team hopes, home in on the cancer, says Lu.

For some cancer patients, viruses engineered to zero in on tumor cells work like a wonder drug.

They use a near - infrared laser beam, which can penetrate deep — in this context, deep means a centimeter or two — into the tissue, where a nanoparticle turns the near - infrared light into blue light, and that directs the activity of genetically engineered immune cells.

The virus, redesigned using sophisticated protein engineering techniques, works: With its shield and its adapter, these viral gene shuttles efficiently infected tumor cells in laboratory animals.

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

Only stem cells from healthy donors or genetically engineered cells should be used in treating cardiac conditions.»

«This shows iPS cells have a lot of problems, but that doesn't mean they don't have potential — just not with the established methodologies used to create them,» says tissue engineer Anthony Atala, director of Wake Forest University Baptist Medical Center's Institute for Regenerative Medicine in Winston — Salem, N.C. «It's a solvable problem, but it looks as if one should look away from methods that don't genetically modify the cell.»

So far, researchers have mostly turned on genes with CRISPRa in cells growing in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not involved in the new study.

The modified cell nuclei were then inserted into unfertilized eggs to create engineered pig embryos, which were implanted in a normal sow.

One of the 12 audience members was Ben Chao, a chemical engineer with a Ph.D. — not at all qualified to make a judgment on Scott's abilities in the area of «Approaches to Developing Serum - Free Media Formulations for Mammalian Cells in Culture.»