Sentences with phrase «cells engineered with»

Remarkably, CD26high T cells engineered with a first generation CD3?

A baby's leukemia was successfully treated in 2015 with CAR - T cells engineered with gene editors known as TALENs.

Not exact matches

Sharei says he is actively discussing partnerships with more drug companies to develop more ways to engineer cells to fight disease, but he declined to identify which drug companies or which diseases.

The squeeze system Sharei then designed to temporarily disrupt cell membranes — for which he's been granted most of his 10 patents — is the basis for SQZ Biotech, the company he co-founded in 2013 with the pioneering MIT professors he worked for: Klavs Jensen, the school's head of chemical engineering, and Robert Langer, a renowned bioengineer and serial entrepreneur.

It houses well - developed test cells where customers can work hand - in - hand with process engineers and technicians to evaluate equipment and processes under controlled, safe, pilot plant conditions.

Most foam crib mattresses have only a very small degree of breathability, but Colgate uses high quality, open cell foam and PE foam engineered with air channels to enhance circulation.

Planning board chairman Drew Boggess, a Rotron engineer and manager, was nominated by his wife Judith and again seconded by Horner, who noted his background as someone familiar with technical aspects of modern life... a theme quietly played out over the evening as some noted Rozzelle's unfamiliarity with and distaste for voice mail, cell phones and email.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

On an additional project with former MIT graduate student Eric Grovender, Ameer co-developed a cartridge filter that purifies blood, «based on protein and cell engineering,» for those suffering from chronic kidney failure.

Eight animals were treated with sphincters engineered from their own muscle and nerve cells, eight animals were not treated and four received a «sham» surgery.

An engineered bone that has its own marrow can encourage donor stem cells to produce blood, a feat that could help people with anaemia and rare immune diseases

The goal of synthetic biology, which combines biology with engineering, is to (re) program cells in order to improve their performance in a specific task, or so that they can efficiently perform a new task.

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body,...

Now that they've shown it's possible to encode and retrieve information sequentially in bacteria, Shipman hopes to create «molecular recorders» — genetically engineered cells with a time log of their activities.

To see whether this also applies to humans, the team engineered stem cells from people with and without Down's syndrome and injected them into mice.

The authors say that successfully linking digital signals with engineered cells represents an important step toward translating similar cell - based therapies into the clinic.

The researchers deployed this technology in yeast cells that are genetically engineered to overproduce a protein associated with Parkinson's disease, known as alpha - synuclein.

When injected into mice engineered with a tau mutation that makes the protein clump abnormally in brain cells, triggering memory and motor problems, the antibodies reduced the clumping and improved the animals» behavior.

Then, to boost the number of cells, which is another hurdle in tissue engineering, the researchers mixed the chondrocytes with human mesenchymal stem cells from bone marrow.

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

Production involves genetic engineering and working with live cells, and it is still mostly done by hand, by highly trained technicians.

«By treating with chemotherapy, we're driving cells through a transition state and creating vulnerabilities,» said first author Aaron Goldman, PhD, a postdoctoral fellow in biomedical engineering at BWH.

Dr. Zubair is working with engineers at the University of Colorado who are building the specialized cell bioreactor that will be taken to the ISS within a year for the experiment.

The virus, redesigned using sophisticated protein engineering techniques, works: With its shield and its adapter, these viral gene shuttles efficiently infected tumor cells in laboratory animals.

«This shows iPS cells have a lot of problems, but that doesn't mean they don't have potential — just not with the established methodologies used to create them,» says tissue engineer Anthony Atala, director of Wake Forest University Baptist Medical Center's Institute for Regenerative Medicine in Winston — Salem, N.C. «It's a solvable problem, but it looks as if one should look away from methods that don't genetically modify the cell.»

So far, researchers have mostly turned on genes with CRISPRa in cells growing in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not involved in the new study.

One of the 12 audience members was Ben Chao, a chemical engineer with a Ph.D. — not at all qualified to make a judgment on Scott's abilities in the area of «Approaches to Developing Serum - Free Media Formulations for Mammalian Cells in Culture.»

To understand that process, the Florida State group engineered a fruit fly to produce a mix of cells, some with normal Lgl and some with the altered version.

«We are the first to engineer a whole liver organ with human cells,» says Shay Soker, a co-developer of the livers at Wake Forest University Baptist Medical Center in North Carolina.

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.

«The combination of natural (leaves) and artificial (photovoltaic cell and electronic components), and the need to make these components communicate with each other, are complex engineering challenges that required us to join forces.»

With the engineered cells, researchers can screen new and existing drugs to see how they regulate alpha - synuclein level in patients.

Researchers at the University of Southampton have engineered cells with a «built - in genetic circuit» that produces a molecule that inhibits the ability of tumors to survive and grow in their low oxygen environment.

So far she has treated mice with the engineered cells, which give rise to HIV - resistant immune cells.

Researchers used molecular scissors called CRISPR / Cas9 to engineer immune cells that were then injected into a patient with lung cancer, Nature reports.

1) Protein and cells, from left to right: engineered protein with yellow - and - black CD3 - binding end and thick black HIV - binding end; latently HIV - infected helper T cell (blue); inactivated killer T cell (red).

Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron - like cells: treating them with exosomes.

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab) model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.

Previously, researchers have produced hydrogen gas in microbial - powered, batterylike fuel cells, but only when they supplemented the energy produced by the bacteria with electrical energy from external sources — such as that obtained from renewable sources or burning fossil fuels, says Bruce Logan, an environmental engineer at Pennsylvania State University, University Park.

Now, with new kinds of technologies that are coming up, new types of tissue engineering and, you know, some of the hopes that people have for stem cells and [the] like, it may be interesting to see if there are other ways, alternatives to dealing with really badly damaged hearts that would involve growing a new heart or replacing or repairing the damage d to a badly damaged heart that might make artificial hearts less important in the somewhat more distant future.

In March 2016, Penn researchers published a study in Blood that showed long - term ibrutinib treatment reverses the dysfunction of T cells in CLL and that combining CAR therapy with ibrutinib enhanced engineered T cell proliferation in mice.

«This paper is a great example of how chemistry can help make step changes in biology,» says Matthew Dalby, a professor of cell engineering at the University of Glasgow and co-senior author on the study with Ulijn.

«Starting with pluripotent stem cells that are not muscle cells, but can become all existing cells in our body, allows us to grow an unlimited number of myogenic progenitor cells,» said Nenad Bursac, professor of biomedical engineering at Duke University.

The researchers experimented with mice that were genetically engineered to have light - sensitive proteins on some of their nerve cells.

So we might just be able to deal with cell loss if we had a sufficiently sophisticated program of stem cell replenishment — using cells engineered to lack the one linchpin function for cancer, namely telomere elongation.

They were then infused with their own engineered «hunter» T cells.

Engineers at Rutgers - New Brunswick and the New Jersey Institute of Technology worked with a hydrogel that has been used for decades in devices that generate motion and biomedical applications such as scaffolds for cells to grow on.

To deliver the healthy gene, the team inserted it into an engineered virus called adeno - associated virus 1, or AAV1, together with a promoter — a genetic sequence that turns the gene on only in certain sensory cells of the inner ear known as hair cells.

Researchers have harnessed the CRISPR - Cas9 technology to correct mutations in the blood stem cells of patients with a rare immunodeficiency disorder; the engineered cells successfully engrafted in mice for up to five months.

The researchers then engineered E. coli cells to produce CsgA tagged with peptides composed of clusters of the amino acid histidine, but only when a molecule called aTc is present.