Sentences with phrase «cells evade»

Dr. Altieri also leads a research program that studies how tumor cells evade programmed cell death and the role of mitochondria, power plant of the cells, in tumor metabolism.

Like a stealth fighter jet, the coating means the cells evade detection by the early - warning immune system that should detect and kill them.

The Altieri laboratory is interested in how tumor cells evade apoptosis — also known as programmed cell death — which is the process that normally causes dysfunctional cells to self - destruct.

Dr. Campisi has found instead that a minority of senescent cells evade destruction by secreting high levels of matrix metalloproteinases (MMPs), which cleave MICA / B ligands and thereby prevent NKG2D binding.

Altieri is interested in how tumor cells evade the normal processes that cause cells with genetic faults to self - destruct.

«Scientists show how cancerous cells evade a potent targeted therapy: Significant antitumor activity was shown in cancers when this therapy was combined with an enzyme.»

A molecule that helps cancer cells evade programmed self - destruction, an internal source of death, might also help malignant cells hide from the immune system, an external source of death.

The 2016 People's Choice Award went to Emmanuelle Alaluf of the Free University of Brussels, for her video using ballet and other dance styles to show how tumor cells evade the immune system.

To dispose of one obvious objection, yes, it's proved we already know all six of the 4 - D regular polytopes — but the 11 - cell evaded attention by having an unusual form.

Not exact matches

This implies that cancer genes, and the mechanisms that allow tumour cells to evade apoptosis, «have deep evolutionary roots».

Some studies are pointing to the fact that the same systems that allow the fetal cells to help with milk production in a mother's breast tissue, also help evade her immune system.

The NYPD does not have to release specific information about «Stingrays,» the department's portable cell phone tracking devices, because the disclosure could help criminals evade detection by law enforcement, a judge ruled.

During the sessions, U.S. and Cuban scientists explored such topics as the molecular mechanisms cancer cells employ to evade the body's immune system, new tools to image and manipulate that system, and ways to rethink how such therapies can best be deployed to reach patients where they receive health services.

Based on the evolutionary idea that targeted epigenetic stochasticity can improve adaptation, these observations could explain how cancer cells are good at evading chemotherapy treatments and spreading from one part of the body to another, he adds.

The experiments point to an immune system cell that evades the toxic effects of cyclophosphamide and protects patients from a lethal form of GVHD.

The findings, in mice and in human stomach cells, also raise questions about how cancer cells may evade treatment.

«This study shows that NF - kB might coordinate a network of immune - suppressor genes whose products enable tumor cells to evade adaptive immunity,» he adds.

Mutations transform the genome of a tumor; its cells become genetic outlaws that spread, ignore normal stop - and - go signals and evade cancer - killing drugs or radiation.

Also, HIV evades the body's CD8 cells by constantly mutating, escaping recognition by CD8 cells and making them ineffective.

«Common cancers evade detection by silencing parts of immune system cells.»

It's evaded our detection so far, but now a hormone made by fat cells, discovered in two people with abnormally low fat, could help treat diabetes and obesity

The frenzied reproduction of cancer cells is also a key part of their ability to evade our assaults, because it is essential to their capacity to evolve new solutions to the challenges that we throw up against them.

After treatment with AZA, the epigenetic changes were reversed, rendering the cancer cells unable to evade the immune system any longer.

These genetic miscues can cause cells to grow out of control, evade the immune system, or fail to execute essential functions needed to maintain health.

Slusher teamed up with Johns Hopkins Kimmel Cancer Center immunologist Jonathan Powell, M.D., Ph.D., who has studied how cancer cells use different metabolic pathways to evade destruction by immune cells.

Now, thanks to the new mouse model, it will be possible to study how renal tumors are able to develop in an environment with a normal immune system, and how cancer cells manage to evade the immune system's attacks.

In a decades - long game of hide and seek, scientists from Sydney's Westmead Institute for Medical Research have confirmed for the very first time the specific immune memory T - cells where infectious HIV «hides» in the human body to evade detection by the immune system.

Some scientists have blamed so - called cancer stem cells, a subset of cancer cells that might be able to remain dormant, evading chemotherapy or radiation treatments, only to form new tumors months or years later.

But cancer cells put out signals that help them evade immune response, say the authors.

These patients were subsequently treated with the drug ketoconazole, which blocks the production of androgens outside of the testes (e.g., those developed by prostate cancer cells that are evading ADT treatment).

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

The new technique seemed to avoid the political pitfalls, and also to evade the perils of rejection since the cells were the patient's own.

Our best approach for battling these microbes is to better understand the tools and tactics used to co-opt our cells and evade the body's defenses.

HIV is also able to evade attack by hiding inside a person's immune cells.

Because diseases such as cancer tend to evade detection by T - cells» receptors, allowing a tumor to grow unchecked, scientists have long sought «intel» on this process as a means of developing therapies that target malignant cells, but leave healthy cells alone.

Cancer Research UK scientists have discovered a new line of defence used by cancer cells to evade cell death, according to research published in Nature Communications.

A new era of lung cancer therapy is close to dawning, using drugs that can prevent tumour cells from evading the immune system, experts have said at the 4th European Lung Cancer Congress.

In fact, researchers at Stanford are already collaborating on initial clinical trials of an antibody that blocks cancer cells from displaying one such death - evading signal — a molecule called CD47.

For a malignant tumor to form, cancer cells must evade the immune system's attack.

Analysis showed that these cells were remapping their routes and finding ways to evade the drug's effect long before any changes could be detected at the clinical level.

Tumor cells develop mechanisms to evade detection by the immune system by expressing a protein called PD - L1.

Considerable success has been achieved in engineering immune cells to evade the suppressive effects of cancer and kill malignant cells.

T. cruzi is already known to disguise its cell surface with human proteins and sugars: apoptosis would be yet another weapon in the arsenal that helps it evade the immune system.

«Brain cancer cells are very good at evading the host immune system, because they do not express specific targets that can be recognized by immune cells,» said Liau, professor and vice chair of neurosurgery.

Researchers found that the drugs, called Hsp90 inhibitors, specifically target and inactivate a mechanism commonly used by prostate cancer cells to evade the effects of standard treatment.

Disease - causing pathogens have been shown to manipulate or attack the ubiquitination process to disarm immune cells and evade the body's defense mechanisms, he said.

Immunologists have suspected that P. falciparum, the most deadly malaria parasite, uses several mechanisms to evade the human immune response and invade red blood cells.

Geneva, Switzerland, 26 March 2014 — A new era of lung cancer therapy is close to dawning, using drugs that can prevent tumour cells from evading the immune system, experts have said at the 4th European Lung Cancer Congress.

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treatment.

In the future, scientists hope to target stem - cell - like cells within cancers that may be responsible for most of the growth of some tumours, and evade existing drugs.