Sentences with phrase «cells express functional»

Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.

A team of researchers led by Rodrigo Lacruz, MSc, PhD, assistant professor in the Department of Basic Science and Craniofacial Biology at NYU College of Dentistry, has published a paper in Scientific Reports (5:15803) titled «Dental enamel cells express functional SOCE channels,» which reports the results of a study showing for the first time the mechanism of calcium transport essential in the formation of dental enamel.

In a subsequent study, they used CRISPR with two gRNAs to delete exon 51 or exons 45 - 55 in patient myoblasts; when injected into DMD mice, these cells expressed functional dystrophin.

Not exact matches

Functional glutamate receptor (GluRs) were transiently expressed in cultured mammalian cells from cloned complementary DNAs encoding GluR - A, - B, - C, or - D polypeptides.

In the current study, Dr. Rudnicki and his team discovered that muscle stem cells also express the dystrophin protein, and without this protein, they produce ten-fold fewer muscle precursor cells, which in - turn generate fewer functional muscle fibres.

Lastly, the team identified a gene, calretinin, in the hippocampal cells which was not expressed in the neocortical cells — suggesting the possibility that these cells exhibit different functional properties as well.

When Lin engineered the telomerase - expressing hepatocytes to die in response to a chemical signal and gave the mice with a liver - damaging chemical, he found that those animals in which the telomerase cells had been killed exhibited much more severe liver scarring than those in which the cells were functional.

For cells to have major functional differences they need to express many genes together that are specific to the function, which will be reflected on a whole tissue level.

EFTF - expressing pluripotent cells form functional retinal cells and eyes when transplanted to the developing embryo, but can these induced retinal cells also differentiate into all the functional retinal cell classes in a mature normal or damaged retinal environment?

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

Transplant of insulin - like growth factor - 1 expressing bone marrow stem cells improves functional regeneration of injured rat uterus by NF -?

When transplanted to the subretinal space of mice lacking functional photoreceptors, human embryonic stem cells directed toward a retinal lineage integrate into the outer nuclear layer, express photoreceptor markers, and restore a light response as determined by the electroretinogram (ERG)[5].

This can come in many different aspects, misfolded proteins located in the cell, expressed too much or too little cell functional defects, premature death when put in proliferation, etc..

In prior work in fruit flies, Haase, Hannon and others demonstrated that when Zucchini was not expressed, single - stranded RNAs that are the precursors for functional piRNAs accumulated in germline cells.

By delivering mRNA drugs via IV to the liver, and directing liver cells to express functional proteins, Moderna can potentially stimulate production of therapeutic proteins in ways that can not be achieved with other current technologies.

We have established stably transfected HEK 293 cell lines expressing high levels of functional human ether - a go - go - related gene (HERG) channels.

Interestingly, cells from both iPS cell lines expressed early cardiac differentiation markers and transcription factors, implicating that there could be a lack in functional cardiomyocyte maturation in line 4.1.

We found that the V+S + population expressed sets of genes that fell into major functional categories that were associated with «Cell adhesion» and «Cell migration.»

The proteins displayed on the merozoite cell surface have long been considered attractive vaccine targets because of their direct exposure to host antibodies; however, progress in understanding the functional role of these targets has been hindered by technical challenges associated with expressing these proteins in a functionally active recombinant form.

Here we report that HB1.F3 NSCs can be engineered to express and secrete functional full - length HER2 - specific human immunoglobulin molecules that can selectively bind to and inhibit the proliferation of HER2 - positive breast carcinoma cells.

The development of a standardized method to express large panels of P. falciparum cell surface and secreted proteins in their native conformation would enable comprehensive protein libraries to be systematically screened in parallel so that direct comparisons between antigens can be made in functional assays such as vaccine screening and immuno - epidemiology studies.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, Doi T, Sone A, Suzuki N, Fujiwara H, Yasukawa M, Ishikawa F. Generation of functional human T - cell subsets with HLA - restricted immune responses in HLA class I expressing NOD / SCID / IL2r ɣnull humanized mice.

In addition, a functional BBB is manifested by a number of permanently active transport mechanisms, specifically expressed by brain capillary endothelial cells that ensure the transport of nutrients into the CNS and exclusion of blood - borne molecules that could be detrimental to the milieu required for neural transmission.