Sentences with phrase «cells express high»

Studies show that human cancer cells express high levels of the fatty acid synthase enzyme, which is associated with aggressive tumor behavior and tumor - cell growth.

ES cell chromatin is open at a global level [3], and the stem cells express high levels of chromatin remodeling factors.

Furthermore, enhanced hiPS - HEP cells express high levels of the LDL receptor (Figure 5, Panel B) and take up fluorescently labeled LDL (Figure 5, Panel A).

Gene expression analysis suggests that club cells express high amounts of antiviral genes in response to infection.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

Using polymerase chain reaction methods that amplify DNA and Jones» assay that detects by - products of ALDH, the Johns Hopkins team found that regulatory T - cells express high levels of ALDH.

«Our work also suggests that cancer cells expressing high levels of BOK may be particularly sensitive to inhibitors that target the proteasome or the ERAD pathway.»

Further, consistent with T cell phenotypes in nontumor - bearing mice (Fig. 2), we observed an increased percentage of spleen - derived CD8 + T cells expressing high levels of the activation marker CD44 in DGKζ − / − or DKO mice that had been inoculated with tumor when compared with Cbl - b − / − or WT mice (Fig. 4C).

Thus while the majority of the V + population existing in ES cell cultures are indistinguishable from undifferentiated ES cells, we also observe differentiated cells expressing high levels of the Venus transgene (arrows in Figure 2B) that resemble the high - level Venus expressors generated in response to differentiation and that probably represent spontaneous PrEn differentiation.

Not exact matches

This protein is expressed at relatively high levels in proliferating precursors and non-neuronal cells but down - regulated in developing neurons by a brain - enriched regulatory RNA called miR - 9.

To test that idea in the ragworm, Tomer used a technique he had developed to examine the complex brains of small creatures with unprecedented clarity: He created a high - resolution map of the worm's brain cells according to the genes they express, not just their shape and location.

The work, which appears in the November 27, 2014, edition of Science Express, points to new avenues for producing single - site supported gold catalysts that could produce high - grade hydrogen for cleaner energy use in fuel - cell powered devices, including vehicles.

«Other miRNAs were being expressed in high levels in the more mature cells, but let - 7 had increased 1000-fold.

Lymphocytes in the grafts of undifferentiated iPS cells were also expressing relatively high levels of genes known to be involved in hostile immune responses.

In contrast, lymphocytes in both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerance.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

When the researchers used gene engineering techniques to knock out DDX3 expression in laboratory - grown cell cultures that highly expressed this protein, cell proliferation was half that of cell cultures with high DDX3 expression.

When the team looked at what gene signatures the RORγt - dependent ILCs expressed, they found high expression of major histocompatibility complex class II (MHCII) protein, which some cells use to display foreign proteins to the immune system and directly interact with T cells.

High - resolution microscope image of an invasive breast cancer cell (magenta) expressing Myosin - 10 induced «sticky - fingers» (green).

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

Consistent with that result, the researchers found that certain regions of the X chromosome in human female B cells, including regions that contain immunity - related genes, were expressed at higher levels than male cells.

While it is present on a number of different types of cells in the body, it is expressed at higher levels on metastatic tumour cells, including those which have spread from the lung.

«Sumudu has shown that liver cells that express high levels of the IFITM proteins are resistant to infection with the hepatitis C virus by blocking entry of the virus into the cells,» Associate Professor Beard says.

As these cells rapidly proliferate, they also express high levels of an enzyme known as activation - induced cytidine deaminase (AID), which induces mutations in their DNA.

The fact that Connexin 30 knockout mice had a higher number of grafted cells than normal mice, and that some of the grafted cells expressed CONNEXIN 30 is a very important finding when considering cell transplantation as a treatment for hereditary hearing loss caused by CONNEXIN deficiency.

Compared with non-human primate cells, human iPSCs expressed higher levels of these restrictors, called APOBEC3B and PIWIL2.

«Patients whose AML cells express FLT3 - ITD are among the highest risk group of patients with AML,» says the study's senior author, Kimberly Stegmaier, MD, of Dana - Farber / Boston Children's Hematologic Malignancies Center.

The explanation: Heat caused the HEV cells to express on their surface higher levels of two so - called «homing» molecules, ICAM - 1 and CCL21, which make lymphocytes tightly adhere to the HEV cells.

In a paper in the high - impact journal Cell Research, published April 4, 2017, researchers at the Hebrew University of Jerusalem report the discovery of an entirely new mechanism through which globin genes are expressed.

Lin found that, in mice, about 3 - 5 percent of all liver cells express unusually high levels of telomerase.

The researchers showed that the iPS cell teratomas expressed high levels of certain genes that could trigger immune cells to attack.

B, Histograms of GFP and P2X3 normalized immunoreactivity of individual cells showing that whereas the P2X3 staining shows a unimodal normal distribution (mean 0.58), the GFP population is bimodal suggestive of high - expressing (mean = 0.69) and low - or nonexpressing populations (mean 0.12).

E, Histograms of GFP and FG normalized fluorescence intensity of individual cells showing bimodal distributions suggestive of a high - expressing population (mean GFP: 0.59, FG: 0.62) and a nonexpressing population (mean GFP: 0.08, FG: 0.08).

Recently, several observations suggested that, besides monocyte - derived macrophages, dendritic cells, a distinct myeloid lineage, also express PPARγ at high levels.

The authors discovered that FGF2 treatment forced a high percentage of astrocytic cell - cycle re-entry via FGF receptor - induced phosphorylation of ERK and mediated the generation of self - renewing Nestin - expressing NSCs.

Using white fat tissue from liposuction or weight - loss surgery, «we might purify a population of these progenitor cells from an obese individual expressing C29 with high potential to become energy - dissipating cells,» she explains.

Being stably and constitutively expressed at high levels in most tissues and cells, GAPDH is considered a housekeeping protein.

When T cells expressing LIGHT were introduced into the mice, lipid levels rose, both when the mice were fed a regular diet, and also when fed a high - fat, high - cholesterol diet.

In addition, the organs and tissues that possess high levels of SDF - 1, such as liver, lung, bone marrow, and lymph nodes, attract the migration of CXCR4 - expressing cancer cells [22].

Coukos, who is currently leading an ovarian cancer clinical trial sponsored by CRI's Clinical Accelerator, sought to understand why PD - 1 / PD - L1 immunotherapies are often ineffective for these patients, even though ovarian tumors are often infiltrated by «killer» T cells that recognize tumor - specific neoantigens and express high levels of PD - 1.

Sun found that the fat stem cells actually express higher starting levels of two of the four reprogramming genes than do adult skin cells — suggesting that these cells are already primed for change.

We have established stably transfected HEK 293 cell lines expressing high levels of functional human ether - a go - go - related gene (HERG) channels.

High throughput injection of poly (A) + RNAs into Xenopus oocytes (in collaboration with Biopredic International) to obtain cells expressing molecules characteristic of certain cell types on their surface.

Expression of the familial PD - linked A53T or A30P mutant ASs in cell models results in an increased proportion of CTTAS being produced than is the case when expressing the WT protein; consistent with this, a higher proportion of the total soluble AS in human brain tissue with AS neuropathology is CTTAS, and a higher proportion yet of the total AS in insoluble AS deposits.

Our older data had shown that the molecules B7 and ICAM could costimulate naïve T cell activation when expressed in isolation, but an efficient response, including high levels of CD40L, IL - 2, and short - term proliferation, resulted only when both B7 and ICAM were able to signal through CD28 and LFA - 1 at the same time (Dubey, 1995, J Immunol; Jaiswal, 1996, Int Immunol; Rogers, 1998, J Immunol).

(6) Following this initial test of abrogating the early, age - related rise in p16Ink4a - expressing cell burden, the investigators probed the effects of leaving BubR1H / H; INK - ATTAC to undergo 5 months of rapid «premature aging» (and thus, to the attendant accumulation of high levels of p16Ink4a - positive cells and onset of «early - aging» phenotypes), and only then inducing ablation of senescent cells with the INK - ATTAC drug - activated system (see Figure 2 (g) below).

Since murine NSCs already express high levels of Sox2 [14]--[16], it was tested whether these cells could be reprogrammed into iPS cells by only a few critical factors.

Since we know the Gal4 - UAS system is sensitive to temperature and in fact, expression levels of these transgenes differ at 22 °C and 25 °C, Drosophila GBPs might also suppress ILP secretion from the insulin - producing cells when expressed at high concentrations.

Inventors at MUSC have identified a unique human CD4 + T cell population that expresses high levels of surface CD26, termed CD26high T cells, which mediate durable antitumor immunity in vivo, and have immediate clinical relevance for designing new vaccines and cellular therapies.

Cells that express high levels of the transcription factor myc up - regulate glutaminase expression more than 10-fold [105].