Sentences with phrase «cells express more»

Then these founder cells express more proteins that keep them alive, allow them to divide and divide, bring them blood and nutrients, and help them grow into new metastatic tumor colonies.

Not exact matches

Conversely, if God is seen primarily as the expressed psychicalization in process of a multiplicity of event - cells, how can there be anything more than just that: psychicalized event - cells?

In the new study, the scientists expressed surprise that the early abnormal growth of brain cells they observed in the fish embryo specifically affected male hormones, potentially indicating why more boys than girls are diagnosed with certain neurodevelopmental disorders such as autism.

The trimer - expressing cells even died more quickly than cells expressing mutant forms of SOD1 that are found in severe hereditary ALS cases.

They found — as they did in the 2016 study — that when these cells expressed SOD1 mutants that predominantly form trimers, the cells died much more quickly than control cells containing normal SOD1.

«But if you have stem cells that are over expressing this protein TRAF6, they may proliferate longer and they may repair the muscle much more effectively.»

As cells differentiate, their DNA becomes more tightly packed, and genes that are no longer needed — or those which should not be expressed — are blocked.

«Other miRNAs were being expressed in high levels in the more mature cells, but let - 7 had increased 1000-fold.

In a previous related study published in the Journal of Materials Science: Materials in Medicine, the same team of NTU scientists found that fish scale - derived collagen would induce human umbilical vein endothelial cells to express 2.5 times more of a specific type of collagen responsible for blood vessel formation, as compared to endothelial cells cultured on bovine collagen.

The researchers then compared tumor cells isolated from multiple different breast cancer patients and found that cells expressing lower amounts of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.

Specifically, the bipolar neurons expressed more genes for membrane receptors and ion channels than non-bipolar cells, particularly those receptors and channels involved in the sending and receiving of calcium signals between cells.

The researchers found that, in test animals, modification of the blood - forming stem cells resulted in more than two years of stable production of CAR - expressing cells without any adverse effects.

More importantly, the fibronectin part of the complex is expressed during a cell's transition to cancer and plays a role in cell growth, migration and differentiation.

She's looking at all the genes — including the original 19 and many more — expressed by each cell in the connected regions.

When this clone was inserted into a mammalian expression vector and transfected into COS - 7 cells, a protein that specifically phosphorylated the agonist - occupied form of the beta 2 - adrenergic receptor and phosphorylated, much more weakly, the light - bleached form of rhodopsin was expressed.

In one experiment, the researchers created arrays of mammary epithelial cells and asked how adding one or more cells expressing low levels of the cancer gene RasG12V affected the cells around them.

What's more, the disrupted circadian oscillations in the MYC - expressing cancer cells could be partially rescued by inhibiting expression of REV - ERBα.

They found that normal cells grow faster when in an organoid with cells expressing RasG12V at low levels, but required more than one mutant cell to kick - start this abnormal growth.

A large body of research has reported that Nanog is allelically regulated — that is, only one copy of the gene is expressed at any given time — and fluctuations in its expression are responsible for the differences seen in individual embryonic stem (ES) cells» predilection to differentiate into more specialized cells.

The elongated fibroblasts reprogrammed to become more T - cell - like in shape and hundreds of T - cell genes were also expressed in these skin cells.

These inhibitors effectively targeted and blocked Msi expressing cells, resulting in halted tumor growth in animal models as well as in patient - derived cancer cells, which harbor more complex mutations and are uniformly drug - resistant.

The more it's expressed only on cancer cells, the more targeted the therapy becomes,» says Colin Weekes, MD, PhD, CU Cancer Center investigator and assistant professor in the Division of Oncology at the CU School of Medicine.

The sperm lack the green glow, Okabe has found, because the protein is expressed in the cell cytoplasm, and sperm are little more than nucleus and tail.

The scientists already knew how to encourage mouse embryonic stem cells to express nestin, and they wondered if they could coax their nestin - positive cells to take on more characteristics of pancreas cells.

This suggests that the instantaneous peak power delivered to the specimen may be an even more important metric of cell health than the total photon dose and should enable extended 3D observation of endogenous levels of even sparsely expressed proteins produced by genome editing.

The genomes of the aged macrophages expressed more genes that hinder a group of molecules that spread signals between nerve cells, called catecholamines.

It was even more surprising to observe that in absence of Sox9, pre-cancerous cells disappear over time, suggesting that we can eliminate oncogene expressing cells before cancer formation» comments Jean - Christophe Larsimont, the first author of this study.

However, the Connexin 30 knockout mice had more grafted cells than the normal mice, and some of the grafted cells were found to express CONNEXIN 30.

When Lin engineered the telomerase - expressing hepatocytes to die in response to a chemical signal and gave the mice with a liver - damaging chemical, he found that those animals in which the telomerase cells had been killed exhibited much more severe liver scarring than those in which the cells were functional.

Kaplan - Meier analysis demonstrated that most of the mice injected with cells expressing wild - type PREX2 or GFP exhibited tumor - free survival for more than ten weeks.

These cells express common and unique extracellular matrix and tendon genes that are more specialized to support the mature scar.

Dr. Zhu said loss of the gene and the protein it expresses may accelerate regeneration by reorganizing how genes are packaged in the genome so that the cells can more easily switch back and forth toward a more regenerative state, sort of like a toggle switch.

These results indicate the eye field and EFTF - expressing pluripotent cells are more closely related to each other than to either the PNP or LE tissues (Figure S1).

The endothelial cells in insulin - receptor knockout mice expressed more of the VCAM - 1 adhesion molecule that helps white blood cells grab onto the growing plaques, and blood vessels gathered four times as many white blood cells.

Immunological Invisibility Cloak Among them is Joel Linden, Ph.D., who recently reported that jamming signals transmitted by membrane proteins called adenosine receptors, which are expressed on T cells and on specialized cell - killing cells called NK cells, made both cell types more effective in halting lung metastasis of melanoma cells.

To develop a more general strategy of cell targeting, the researchers coupled nanoparticles to antibodies that target other highly expressed proteins in neurons.

Two other more mature brain cell types, astrocytes and microglia, which can migrate in the brain, also express the AXL gene.

Vesicles in the cells expressing BNPI loaded two to four times more glutamate than those from the unaffected cells.

Included among the numerous recipients of Mr. Sanford's gifts, that total more than one billion dollars, are: the Edith Sanford Foundation for Breast Cancer that was created in 2012 by a gift of $ 100 million in honor of Mr. Sanford's mother who died of breast cancer when he was four years old; the Sioux Valley Hospitals and Health System, which renamed itself Sanford Health in 2007, in recognition of a $ 400 million gift; a $ 125 million gift in 2014 to establish Sanford Imagenetics, a program that will integrate genomic medicine into primary care for adults; the University of California San Diego which received a $ 100 million gift for the creation of the Sanford Stem Cell Clinical Center in 2013 to accelerate the translation of stem cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative MedicCell Clinical Center in 2013 to accelerate the translation of stem cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Mediccell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Medicine.

By comparing the V. carteri germ and somatic cell transcriptomes, Matt and Umen found that the somatic cells had more transcripts from young, lineage - specific genes, whereas the germ cells had more transcripts from ancient genes that are similar to those expressed in stem cells from animals and land plants.

(6) However, it would be useful to see a more thorough analysis of the effect of ablating p16Ink4a - expressing senescent cells, and whether there may instead be evidence of a short - term rejuvenation of tissue function that is slowly lost over time to rising levels of other kinds of aging damage that INK - ATTAC activation does not address.

Although counterintuitive, this is reminiscent of the way certain pluripotent stem cells in other systems express a greater number of genes — including more ancient genes — than their somatic daughter cells do.

The germ cells also expressed more genes overall than the somatic cells did, despite being specialized for reproduction.

In addition, brains cultured with the conditioned media from GBP1 or GBP2 expressing cells revealed that diluted media induced ILP2 and ILP5 secretion more effectively.

Turning their attention to the single - cell level, they mapped more than 12,000 proteins to 30 subcellular structures, in turn defining the proteomes — the complete sets of expressed proteins — of more than a dozen major organelles.

Cells that express high levels of the transcription factor myc up - regulate glutaminase expression more than 10-fold [105].

Tang wondered if he could use previously established mouse lines expressing GFP in specific cell types to do more than just label cells.

A major scientific puzzle, said Singh, has been how and why immature hematopoietic stem cells initially express genes that are characteristic of more than one cell lineage.

* tilapia do not express alpha (1,3) gal, a carbohydrate structure present on mammalian cells that causes hyperacute rejection Read more

Although none of the genes were exclusively expressed in the annelid mesodermal midline, their combined coexpression was unique to these cells (implying that mesodermal midline in annelids and chordamesoderm in vertebrates are more similar to each other than to any other tissue).