Sentences with phrase «cells expressed cxcr4»

In the R5 - ZFN control group, with intact cxcr4 genes, 88 % of CD4 + T cells expressed CXCR4 protein at day 27 post engraftment, compared to 84 % of cells in the X4 - ZFN mice (∼ 24 % cxcr4 gene disruption) as determined by a fluorescence minus - one (FMO) control.

Following coronary artery occlusion, SDF - 1α level is increased in the infarcted area, resulting in the recruitment of progenitor cells expressing CXCR4 for post-infarct repair [47].

Not exact matches

To examine this, we transiently expressed CXCR4Δ18 or wt CXCR4 as a control in 293T cells, which have low endogenous CXCR4 expression.

Our long - term goal, therefore, is to explore the potential to genetically disrupt both ccr5 and cxcr4 for cell replacement therapies in HIV infected individuals, and in the case of cxcr4 do so in a way that specifically targets CXCR4 on T cells and not the many other cell types on which it is exprecxcr4 for cell replacement therapies in HIV infected individuals, and in the case of cxcr4 do so in a way that specifically targets CXCR4 on T cells and not the many other cell types on which it is exprecxcr4 do so in a way that specifically targets CXCR4 on T cells and not the many other cell types on which it is expreCXCR4 on T cells and not the many other cell types on which it is expressed.

To evaluate coreceptor tropism, a representative Env from the X4 - ZFN mice and the viral innoculum were pseudotyped and used to infect NP2 cell lines expressing CD4 and either CCR5 or CXCR4.

As full length Bk132 Env would not pseudotype on an NL43 HIV core we truncated the cytoplasmic tail of the Envs [49], [50], and conducted tropism testing on NP2 cell lines expressing CD4 with either CCR5 or CXCR4.

SDF - 1 is predominantly overexpressed in skin and kidney, making them the final destinations of CXCR4 - expressing cells.

The parent TZM - bl cell line is an engineered HeLa cell clone that expresses human CD4, CCR5 and CXCR4 and contains HIV - 1 Tat -

GCSF and hypoxia inducible factor - 1α (HIF - 1α) have been shown to up - regulate SDF - 1α in the infarcted area in a rabbit ischemia model and promote the migration of CXCR4 expressing cells towards cardiac tissues [47 - 49].

Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.

The parent TZM - bl cell line is an engineered HeLa cell clone that expresses human CD4, CCR5 and CXCR4 and contains HIV - 1 T

Human CD4 cell expressing Simian CXCR4.

The parent TZM - bl cell line is an engineered HeLa cell clone that expresses human CD4, CCR5 and CXCR4 and contains HIV - 1 Ta

SDF - 1 is expressed in synovial epithelial cells and it has been reported that persistent induction of CXCR4 by stromal derived factors, such as TGF - β led to SDF - 1 mediated accumulation of CD4 T cells within the rheumatoid joint [44].

In addition, the organs and tissues that possess high levels of SDF - 1, such as liver, lung, bone marrow, and lymph nodes, attract the migration of CXCR4 - expressing cancer cells [22].

CXCR4, which is a chemokine receptor, is expressed in migratory and post-migratory germ cells in vivo in mice [27], and is also a marker for germ cells derived from human ES cells [28], thus suggesting that CXCR4 is a candidate marker gene for detecting ES cells - derived germ cell in monkeys.