Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self - tolerance maintained by activated T
cells expressing IL - 2 receptor alpha - chains (CD25).
Marnik and other members of the Roopenian lab noticed that a subset of helper
cells express IL - 21 soon after birth — much earlier than expected.
Not exact matches
We show here that acidic mammalian chitinase (AMCase) is induced via a T helper - 2 (Th2)-- specific, interleukin - 13 (
IL - 13)-- mediated pathway in epithelial
cells and macrophages in an aeroallergen asthma model and
expressed in exaggerated quantities in human asthma.
And
IL - 22 helped tumor
cells express stem -
cell genes through epigenetic changes to these genes.
The
IL - 2 receptor α subunit, CD25 is commonly
expressed in T - regulatory (Treg)
cells and a small subset of Reed - Sternberg
cells in Hodgkin's Lymphoma (HL).
Furthermore, the laboratory is actively investigating how the interaction of
IL - 10 with the
IL -10-receptor
expressed on regulatory T
cells controls Foxp3 expression and Treg function.
However, some reports show that MSC do constitutively
express mRNA for cytokines such as
IL - 6, -7, -8, -11, -12, -14, -15, -27, leukaemia inhibitory factor, macrophage colony - stimulating factor, and stem
cell factor 148, 149.
Our older data had shown that the molecules B7 and ICAM could costimulate naïve T
cell activation when
expressed in isolation, but an efficient response, including high levels of CD40L,
IL - 2, and short - term proliferation, resulted only when both B7 and ICAM were able to signal through CD28 and LFA - 1 at the same time (Dubey, 1995, J Immunol; Jaiswal, 1996, Int Immunol; Rogers, 1998, J Immunol).
The
IL -1-like cytokine
IL - 33 is constitutively
expressed in the nucleus of endothelial
cells and epithelial
cells in vivo: a novel «alarmin»?
Most ILCs that produced
IL - 22 also produced GM - CSF, but not all GM - CSF
expressing cells produced
IL - 22 (Fig 6B).
The release of inflammatory cytokines, or intercellular signaling molecules such as interleukin - 1 (
IL - 1), interleukin - 2 (
IL - 6), and tumor necrosis factor alpha (TNF - α) at the site of immune activation causes other immune
cells migrating throughout the lymphatic vessels of the body to
express more
cell adhesion molecules (CAMs).
Higgins describes studies showing that rats fed resistant starch show decreased numbers and sizes of lesions due to colorectal cancer, and an increased number of
cells that
express the protein
IL - 10, which acts to regulate the body's inflammatory response.