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Not exact matches
A team led by Byeong - Chun Lee of Seoul National University in South Korea created the dogs by cloning
fibroblast cells that
express a red fluorescent gene produced by sea anemones.
Fibroblasts (red)
express endothelial markers (green), making the heart
cells in mice appear yellow.
To explore this idea, they induced heart attacks in mice and then studied the
fibroblasts to see if the
cells expressed markers characteristic of endothelial
cells.
The elongated
fibroblasts reprogrammed to become more T -
cell - like in shape and hundreds of T -
cell genes were also
expressed in these skin
cells.
To convert the
fibroblasts into muscle
cells, the researchers transfected the
fibroblasts with the cDNA of MyoD, forcing the
cells to
express MyoD (Davis et al., 1987).
The α3, α4, and α7 nAChR subunits were
expressed in cerebellar
cells but not in kidney
fibroblasts.
Yamanaka's group used human adult dermal
fibroblasts and induced them to become iPSCs, appearing and functioning like hESCs, by having them
express the same proteins as he used with mouse
cells: Oct - 4, Sox2, Klf4, and c - Myc (Takahashi et al., 2007).
They made adult fibroblastic mouse
cells become essentially mouse embryonic stem
cells, in appearance and function, by forcing the
fibroblasts to
express four key embryonic stem
cell factors: Oct - 4, Sox2, Klf4, and c - Myc.
«In
cells that don't produce antibodies, like
fibroblasts or T -
cells, these antibody genes are attached to the inner nuclear membrane and are not recombined or
expressed,» said Singh.
Remarkably, a combination of just three of the factors (Gata4, Mef2c, and Tbx5) was enough to efficiently convert
fibroblasts into
cells that could beat like cardiomyocytes and turned on most of the same genes
expressed in cardiomyocytes.
Five beagles were created by cloning
fibroblast cells that
express a red florescent gene produced by sea anemones.
We hypothesize that SSEA3 expression is either identifying another less differentiated and / or tissue specific stem
cell like population that is retrieved with the donor skin biopsy or that with culture, a subpopulation of
fibroblasts may acquire the ability to
express SSEA3.
Mouse
fibroblast cells expressing HP1alpha, the human version of heterochromatin protein 1a.
We derived a
fibroblast line from a skin biopsy from a healthy adult male (HUF1)(Figure 1A) and used immunocytochemistry to characterize the expression of
cell surface markers commonly
expressed on pluripotent stem
cells (Figure 1B, C and D).