Sentences with phrase «cells find a niche»
She will study how normal, healthy bone marrow stem cells find a niche and how niche environment regulates stem cell functions such as self - renewal and differentiation.
http://www.uchospitals.edu/ Not exact matches
In that spot, the scientists found a niche of angioblasts, those same cells that a hundred years earlier were thought to be the source of lymph vessels, but were later neglected.
Researchers from the Department of Biomedicine at the University of Basel have now found that the fate of adult hippocampal stem cells is not only controlled by their local niche, but also by a cell - intrinsic mechanism.
Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.
«Single gene encourages growth of intestinal stem cells, supporting «niche» cells, and cancer: Finding in mice could lead to new therapies for damaged organs, cancer.»
«We have found a way by which cytokinesis is temporarily halted and later started back up, and this phenomenon coordinates all cell players in the maturation of sperm cells in this niche,» says DiNardo.
This striking finding shows that regulation of cytokinesis is how this niche coordinately produces daughter cells from different stem cell types.
The lab previously found that Bam is required to repress the expression of E-cadherin, a cell - to - cell adhesion molecule that tethers adult stem cells to their tissue niches and promotes GSC self - renewal.
Only when they have found the right environment do the cells then drop into that niche — like the roulette ball falling into a numbered slot — and differentiate definitively.»
«Additionally, these findings point to a promising strategy for delivering stem cells to targeted niches for their long - term maintenance and generation of functional cells through augmented stem cell competition.»
The other one, the finding by the Clevers group in Utrecht that adult Lgr5 + stem cells from the intestine, grown 3D in the presence of basement membrane matrix and a defined set of niche factors, can develop into ever - expanding, genome - stable 3D organoids that resemble the structure and function of the original intestinal epithelium (13 - 16).
Melanocytes have the capacity to respond to a diverse number of extracellular signals, including UVR, endocrine signaling cascades that occur during pregnancy, micro-environments of the stem cell hair bulge vs. differentiated hair follicle niches, and hypoxic conditions found in metastatic melanoma tumors.
«These findings generally support earlier hypotheses about the stem cell niche environment,» says Vinogradov.
Still, it would be a tough sell for a film about terrorist cells to find a niche in today's post Sept. 11 society regardless of how good the film is.