Sentences with phrase «cells from patients who»

They then examined the effect of a chemical that inhibits SRF and found that glucose uptake rates increased in both mice and human cells — and that the effects were greater in cells from patients who were insulin resistant or had type 2 diabetes.

But cells from patients who hadn't been helped by the drug remained hyperexcitable.

They show that it is possible to derive iPS cells from a patient who has a mix of mutant and normal mtDNA (is heteroplasmic), where the separate cell lines can have anything from 0 to 100 % mutant mtDNA, but the same nuclear DNA.

Not exact matches

Speaking of Novartis — the company's experimental CTL019, which is expected to be the first approved drug in a revolutionary new cancer treatment space that turns the body's own immune cells into cancer - killers, is already facing some apprehension from doctors and patient groups who are worried about its eventual pricing.

In a group of patients who underwent surgery for epilepsy, over half had stem cells where healthy individuals do not have them, according to a study from Sahlgrenska Academy.

The decision was seen as an effort to mollify the religious fundamentalists at the core of Bush's political support who are ideologically opposed to deriving the cells from frozen embryos in fertility clinics and scientists and patients who hope that the cells could be used to help patients with Parkinson's, Alzheimer's, spinal - cord injuries, and diabetes.

«I'm working with Professor Richard Oreffo and Dr Rahul Tare from the University's Centre for Human Development, Stem Cells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explCells and Regeneration who are trying to create and grow cartilage in the lab using a patients» own (autologous) stem cells to then be implanted back into the patient if they have a cartilage defect,» she explcells to then be implanted back into the patient if they have a cartilage defect,» she explains.

Scientists from the University of Cambridge's Institute for Medical Research obtained skin cells from 10 patients — seven who had various forms of inherited liver disease, and three healthy controls.

Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.

The researchers obtained stem cells from the discarded fat of liposuction patients who underwent elective surgery.

The estimation of EGFR mutation status is essential for the identification of non-small cell lung carcinoma (NSCLC) patients who may benefit from treatment with EGFR tyrosine kinase inhibitors (TKIs), and hence for improving therapeutic efficacy.

Preventing this from happening is a specific responsibility of health authorities and governments worldwide to make sure that the hope and trust of patients are not misused,» remarked Elena Cattaneo, Director of the Centre for Stem Cell Research at the University of Milan, Italy, and one of the scientists who contributed to the commentary.

And it suggests that stem cells derived from embryos should remain the primary reference for iPS cells when researchers want to compare how cells from diseased patients behave, says Nissim Benvenisty of Hebrew University of Jerusalem, who has studied differences between ES cells and iPS cells derived from carriers of fragile X syndrome.

«We've taken white cells from his body, put them in a culture with malignant cells, and they gobble them up,» says Michael O'Rourke, who is treating the patient.

He did, however, publish a paper last year documenting a study in which he infused three cancer patients with white blood cells from young donors who had been injected with G - CSF.

Analyzing small intestine biopsy samples from food allergy patients (who gave authorized consent) the scientists looked for molecular signatures of MMC9 cells.

The team found that obese people with kidney cancer had a 53 % lower risk of dying from renal - cell carcinoma than patients who were normal weight2.

In recent studies of cancer patients who received a bone marrow transplant, genes from the marrow's white blood cells were found in the patient's tumor cells.

The good bacteria seem to help the drugs by priming T cells, which Wargo's group reported were more abundant in the gut and tumors of the mice who got fecal transplants from responder patients.

Abatacept, when added to the standard drug regimen used to prevent GvHD, reduced the occurrence of acute, grade III - IV GvHD from 32 to 3 percent in pediatric and adult patients who underwent mismatched unrelated donor stem cell transplants to treat advanced cancer and other blood disorders.

It found that patients who received a liver and kidney at the same time, or a liver alone, had fewer of the cells that leap into action to defend the body from an invader — known as killer cells or T cells — , compared with people who had a kidney transplant alone.

The newfound protein might eventually help patients who suffer from the untreatable prion diseases: When the group mixed their artificial protein fragment with a fragment of the PrP protein that usually kills neurons in petri dishes, the mixture killed only half as many cells as the prion fragment alone.

In the new work, the researchers added serum from Finnish narcolepsy patients who had received Pandemrix to cells that were engineered to display human hypo cretin receptor 2 on their surface.

John Rossi, a molecular biologist at the Beckman Research Institute in Duarte, Calif., who was not involved in the research, noted that from his own work, using RNAi to treat T cells may allow patients to significantly reduce the dosage of the anti-HIV drugs — up to 100-fold.

To test VX - 770, the doorman drug, researchers used lung cells from a CF patient with the G551D mutation — the same one sickening the Cheevers girls, who required only a doorman drug to function in healthy mode.

Helping to protect newborns and older patients against more severe effects of jaundice is the hope of University of Guelph researchers, who have shown how a liver enzyme protects cells from damage caused by the condition.

«It is exciting that they have generated human cells from the patient material,» says stem cell researcher Jeffrey Rothstein of Johns Hopkins University in Baltimore, Maryland, who also studies ALS.

In the first published results from a clinical trial using human embryonic stem cells, two legally blind patients who received an injection of hESC - derived cells in one eye have experienced no harmful side effects and appear to have slightly better vision.

Since our collection of cell lines is completely genetically annotated — which means that mutations and expression changes in each line's genes have been documented — we should be able to identify in advance patients who will benefit from specific combinations.

Neither line could be traced to the patients suffering from spinal cord injury, diabetes, or an immune disorder who had donated skin cells for the work.

They were derived from skin cells obtained from patients who have had type 1 diabetes for 50 years or more and are members of the Joslin 50 - Year Medalist Program, and also from healthy controls.

Patients who participate in testing experimental stem cell therapies, whether in regulated clinical trials or from clinics offering unproven therapies, are pioneers.

The current study, published in the journal Cell, involved a family of patients who suffer from congenital heart disease and carry a mutation in GATA4.

The Phase I safety trial, funded with a pilot grant from The National Institutes of Health and support from the Notsew Orm Sands Foundation, will enroll nine more patients who have suffered a stroke and can be treated with the stem cell procedure within 24 to 72 hours of initial symptoms.

Healthy individuals» lungs contain very few goblet cells, but patients who die from asthma — an estimated 5,000 people annually — have significantly higher numbers of these cells.

Sure enough, when the researchers examined the brains of PD patients, they found more cells exhibiting signs of senescence than in people without the disease — and especially astrocytes, as they had expected.7 This was true even after matching patients for age, meaning that PD subjects had even more senescent astrocytes in their SNcs than is typical for people their age (ranging in this case from 50 — 92 years at autopsy)-- and remember, aging already drives an increase in the burden of these cells as compared with young people, even in those who have yet to develop Parkinson's disease.7

Hear stories from patients who have recovered from leukemia and other blood cancers thanks to stem cell transplants; the donors who provided stem cells to loved ones; and the medical staff that cared for them before, during, and after the procedure.

Researchers have found that treating patients who have early stage non-small cell lung cancer with a type of radiotherapy called stereotactic body radiation therapy is associated with a small but increased risk of death from causes other than cancer.

For those patients who suffer from heart failure symptoms with no other option for treatment, stem cell therapy holds the potential to provide a better quality of life.

They compared tissue from 91 patients who did not have T cell invasion with tissue from 106 patients with T cell - driven inflammation.

The HUB is founded on the pioneering work of Hans Clevers, M.D., Ph.D., who discovered methods to grow stem cell - derived human epithelial mini-organs from the tissues of patients with various diseases.

METHODS: Peripheral blood mononuclear cells obtained from patients who received AN1792 were stimulated in vitro either with beta - amyloid (Abeta) or various overlapping peptides of Abeta (1 - 42), followed by quantification of cytokine - secreting cells by enzyme - linked immunosorbent spot assay.

Scientists who used modified stem cells to rejuvenate damaged and aged heart cells from elderly heart failure patients say their...

Ultimate use of newborn stem cells will be determined by the treating physician who will consider if they are applicable for the condition and should come from the patient or a suitable donor (siblings of the same biological parents have a 25 % chance of being a perfect match and a 50 % chance of being a partial match; biological parents will always be a partial match).

«We have already received four remote tumor samples and generated two new ROS1 cell lines from patients who never even had to travel to University of Colorado,» says Doebele.

To do so, the researchers created neurons from skin cells donated by Alzheimer's patients with two copies of the apoE4 gene, as well as from healthy individuals who had two copies of the apoE3 gene.

A Dutch doctor who sent people with multiple sclerosis from the United Kingdom for controversial stem cell injections at his clinic in Rotterdam faces allegations of dishonesty and exploiting vulnerable patients.

The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.

Now biologists have used stem cells from these patients, who have a devastating disorder called Timothy syndrome, to grow their brains a second time — in miniature, in a lab dish.

«The scientists at the University of Michigan Center for Pluripotent Stem Cell Research monitor the cells daily and have learned that cells taken from bipolar patients fire more intensively and in a way that is significantly different than cells from an individual who doesn't have bipolar disorder,» said Melvin McInnis, M.D., the Prechter Fund research director.